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• W2805251607 abstract "Abstract Depressive patients often experience difficulty in performing exercise due to physical and psychological barriers. We examined the effects of 5-aminolevulinic acid (ALA) with sodium ferrous citrate (SFC) supplementation during home-based walking training in middle-aged depressive women. Nine outpatients [53 ± 8 (SD) yr] with major depressive disorder participated in the pilot study with randomized, placebo-controlled, double-blind crossover design. They underwent two trials for 7 days, each performing interval walking training (IWT) with ALA + SFC (ALA + SFC) or placebo supplement intake (PLC) intermittently with >a 10-day washout period. For the first 6 days of each trial, exercise intensity for IWT was measured by accelerometry. Before and after each trial, subjects underwent a graded cycling test, and lactate concentration in plasma ([Lac − ] p ), oxygen consumption rate ( $${dot{{bf{V}}}{bf{O}}}_{{bf{2}}}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>V</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> <mml:mi>O</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msub> </mml:math> ), and carbon dioxide production rate ( $${dot{{bf{V}}}{bf{text{CO}}}}_{{bf{2}}}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>V</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> <mml:mtext>CO</mml:mtext> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msub> </mml:math> ) were measured with depression severity by the Montgomery–Åsberg Depression Rating Scale (MADRS). We found that the increases in [Lac − ] p , $${dot{{bf{V}}}{bf{O}}}_{{bf{2}}}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>V</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> <mml:mi>O</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msub> </mml:math> and $${dot{{bf{V}}}{bf{text{CO}}}}_{{bf{2}}}$$ <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML> <mml:msub> <mml:mrow> <mml:mover> <mml:mi>V</mml:mi> <mml:mo>˙</mml:mo> </mml:mover> <mml:mtext>CO</mml:mtext> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msub> </mml:math> during the test were attenuated only in ALA + SFC ([before vs. after] × workload; all, P < 0.01), accompanied by increased training days, impulse, and time at fast walking during IWT (all, P < 0.05) with decreased MADRS-score (P = 0.001). Thus, ALA + SFC supplementation increased IWT achievement to improve depressive symptoms in middle-aged women." @default.
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• W2805251607 date "2018-05-08" @default.
• W2805251607 modified "2023-10-12" @default.
• W2805251607 title "Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged depressive women: randomized, double-blind, crossover pilot study" @default.
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• W2805251607 doi "https://doi.org/10.1038/s41598-018-25452-2" @default.
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