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• W2805288082 abstract "Abstract Antimicrobial resistance has been estimated to be responsible for over 700,000 deaths per year; therefore, new antimicrobial therapies are urgently needed. One way to increase the efficiency of antibiotics is to use them in combination with bacteria‐specific parasitic viruses, phages, which have been shown to exert additive or synergistic effects in controlling bacteria. However, it is still unclear to what extent these combinatory effects are limited by rapid evolution of resistance, especially when the pathogen grows as biofilm on surfaces typical for many persistent and chronic infections. To study this, we used a microcosm system, where genetically isogenic populations of Pseudomonas aeruginosa PAO 1 bacterial pathogen were exposed to a phage 14/1, gentamycin or a combination of them both in a spatially structured environment. We found that even though antibiotic and phage–antibiotic treatments were equally effective at controlling bacteria in the beginning of the experiment, combination treatment rapidly lost its efficacy in both planktonic and biofilm populations. In a mechanistic manner, this was due to rapid resistance evolution: While both antibiotic and phage selected for increased resistance on their own, phage selection correlated positively with increase in antibiotic resistance, while biofilm growth, which provided generalized resistance mechanism, was favoured most in the combination treatment. Only relatively small cost of resistance and weak evidence for coevolutionary dynamics were observed. Together, these results suggest that spatial heterogeneity can promote rapid evolution of generalized resistance mechanisms without corresponding increase in phage infectivity, which could potentially limit the effectiveness of phage–antibiotic treatments in the evolutionary timescale." @default.
• W2805288082 created "2018-06-13" @default.
• W2805288082 creator A5003700868 @default.
• W2805288082 creator A5080054484 @default.
• W2805288082 date "2018-06-21" @default.
• W2805288082 modified "2023-10-17" @default.
• W2805288082 title "Rapid evolution of generalized resistance mechanisms can constrain the efficacy of phage-antibiotic treatments" @default.
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• W2805288082 doi "https://doi.org/10.1111/eva.12653" @default.
• W2805288082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6183449" @default.
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• W2805288082 hasPublicationYear "2018" @default.
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