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• W2805295142 abstract "Cytochrome P450s form an important group of enzymes involved in xenobiotics degradation and metabolism, both primary and secondary. These enzymes are also useful in industry as biotechnological tools for bioconversion and a few are reported to be involved in pathogenicity. Trichoderma spp. are widely used in industry and agriculture and are known for their biosynthetic potential of a large number of secondary metabolites. For realising the full biosynthetic potential of an organism, it is important to do a genome-wide annotation and cataloguing of these enzymes.Here, we have studied the genomes of seven species (T. asperellum, T. atroviride, T. citrinoviride, T. longibrachiatum, T. reesei , T. harzianum and T. virens) and identified a total of 477 cytochrome P450s. We present here the classification, evolution and structure as well as predicted function of these proteins. This study would pave the way for functional characterization of these groups of enzymes and will also help in realization of their full economic potential.Our CYPome annotation and evolutionary studies of the seven Trichoderma species now provides opportunities for exploration of research-driven strategies to select Trichoderma species for various applications especially in relation to secondary metabolism and degradation of environmental pollutants." @default.
• W2805295142 created "2018-06-13" @default.
• W2805295142 creator A5007647654 @default.
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• W2805295142 date "2018-06-04" @default.
• W2805295142 modified "2023-10-12" @default.
• W2805295142 title "Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships" @default.
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• W2805295142 doi "https://doi.org/10.1186/s40694-018-0056-3" @default.
• W2805295142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5985579" @default.
• W2805295142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29881631" @default.
• W2805295142 hasPublicationYear "2018" @default.
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• W2805295142 citedByCount "27" @default.

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