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- W2805347888 abstract "Internal ribosome entry sites (IRESs) are cis-acting RNA elements capable of recruiting ribosomes and initiating translation on an internal portion of an mRNA. This is divergent from canonical eukaryotic translation initiation, where the 5’ cap is recognized by initiation factors (IFs) that recruit the ribosome to initiate translation of the encoded peptide. All known IRESs are capable of initiating translation in a cap-independent manner, and are therefore not constrained by the absence or presence of a 5’ m7G cap. In addition to being cap-independent, IRES-mediated translation often uses only a subset of IFs allowing them to function independently of canonical initiation. The ability to function independently of the canonical translation initiation pathway allows IRESs to mediate gene expression when cap-dependent translation has been inhibited. Recent reports of viral IRESs capable of initiating translation across taxonomic domains (Eukarya and Bacteria) have sparked interest in designing gene expression systems compatible with multiple organisms. The ability to drive translation independent of cellular context using a common mechanism would have a wide range of applications ranging from agriculture biotechnology to the development of antiviral drugs. Here we discuss IRES-mediated translation and critically compare the available mechanistic and structural information. A particular focus will be on IRES-meditated translation across domains of life (viral and cellular IRESs) , IRES bioengineering and the possibility of an evolutionary conserved translation initiation mechanism." @default.
- W2805347888 created "2018-06-13" @default.
- W2805347888 creator A5037044234 @default.
- W2805347888 creator A5080902418 @default.
- W2805347888 date "2018-01-02" @default.
- W2805347888 modified "2023-10-16" @default.
- W2805347888 title "Viruses, IRESs, and a universal translation initiation mechanism" @default.
- W2805347888 cites W1565208369 @default.
- W2805347888 cites W1569490834 @default.
- W2805347888 cites W1572643844 @default.
- W2805347888 cites W1869889838 @default.
- W2805347888 cites W1969003683 @default.
- W2805347888 cites W1970949525 @default.
- W2805347888 cites W1975122842 @default.
- W2805347888 cites W1981957524 @default.
- W2805347888 cites W1984324996 @default.
- W2805347888 cites W1984902027 @default.
- W2805347888 cites W1990771642 @default.
- W2805347888 cites W1995383156 @default.
- W2805347888 cites W1996399399 @default.
- W2805347888 cites W1997324386 @default.
- W2805347888 cites W2007890475 @default.
- W2805347888 cites W2008359458 @default.
- W2805347888 cites W2008410413 @default.
- W2805347888 cites W2008584932 @default.
- W2805347888 cites W2008741218 @default.
- W2805347888 cites W2009938921 @default.
- W2805347888 cites W2010577232 @default.
- W2805347888 cites W2013303604 @default.
- W2805347888 cites W2014682535 @default.
- W2805347888 cites W2023590131 @default.
- W2805347888 cites W2027745524 @default.
- W2805347888 cites W2028449522 @default.
- W2805347888 cites W2034760423 @default.
- W2805347888 cites W2035711496 @default.
- W2805347888 cites W2037313242 @default.
- W2805347888 cites W2038589110 @default.
- W2805347888 cites W2040204840 @default.
- W2805347888 cites W2041122594 @default.
- W2805347888 cites W2044553149 @default.
- W2805347888 cites W2048731469 @default.
- W2805347888 cites W2066010536 @default.
- W2805347888 cites W2069100555 @default.
- W2805347888 cites W2072077065 @default.
- W2805347888 cites W2073799032 @default.
- W2805347888 cites W2076580369 @default.
- W2805347888 cites W2079918544 @default.
- W2805347888 cites W2085063254 @default.
- W2805347888 cites W2085899914 @default.
- W2805347888 cites W2088359520 @default.
- W2805347888 cites W2088858417 @default.
- W2805347888 cites W2092108158 @default.
- W2805347888 cites W2093291148 @default.
- W2805347888 cites W2096117621 @default.
- W2805347888 cites W2103008797 @default.
- W2805347888 cites W2103059305 @default.
- W2805347888 cites W2104947461 @default.
- W2805347888 cites W2105322823 @default.
- W2805347888 cites W2108239227 @default.
- W2805347888 cites W2111774070 @default.
- W2805347888 cites W2112459919 @default.
- W2805347888 cites W2113338791 @default.
- W2805347888 cites W2118391959 @default.
- W2805347888 cites W2119326805 @default.
- W2805347888 cites W2120498503 @default.
- W2805347888 cites W2124035966 @default.
- W2805347888 cites W2138970689 @default.
- W2805347888 cites W2144024988 @default.
- W2805347888 cites W2147509381 @default.
- W2805347888 cites W2149889840 @default.
- W2805347888 cites W2154128645 @default.
- W2805347888 cites W2154874198 @default.
- W2805347888 cites W2161504007 @default.
- W2805347888 cites W2166064969 @default.
- W2805347888 cites W2167104147 @default.
- W2805347888 cites W2171222823 @default.
- W2805347888 cites W2171323620 @default.
- W2805347888 cites W2175514210 @default.
- W2805347888 cites W2194754715 @default.
- W2805347888 cites W2234324103 @default.
- W2805347888 cites W2330185538 @default.
- W2805347888 cites W2341675948 @default.
- W2805347888 cites W2404951087 @default.
- W2805347888 cites W2545598638 @default.
- W2805347888 cites W2564648847 @default.
- W2805347888 cites W2565972943 @default.
- W2805347888 cites W2626432868 @default.
- W2805347888 cites W2733985479 @default.
- W2805347888 cites W89691187 @default.
- W2805347888 doi "https://doi.org/10.1080/02648725.2018.1471567" @default.
- W2805347888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29804514" @default.
- W2805347888 hasPublicationYear "2018" @default.
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