FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805349718> ?p ?o ?g. }

• W2805349718 endingPage "2079" @default.
• W2805349718 startingPage "2072" @default.
• W2805349718 abstract "Background The development of de novo donor-specific antibodies (dnDSA) has been associated with rejection and graft loss in kidney transplantation, and DSA screening is now recommended in all kidney transplant recipients. However, the clinical significance of dnDSA detected by screening patients with a stable creatinine remains unclear. Methods One hundred three patients younger than 18years receiving a first, kidney alone transplant between December 1, 2007, and December 31, 2013, underwent DSA screening every 3months for 2years posttransplant, with additional testing as clinically indicated. No treatment was given for DSAs in the absence of biopsy-proven rejection. Results Twenty (19%) patients had dnDSA first detected on a screening test, and 13 (13%) patients had dnDSA first detected on a for-cause test. Mean follow-up time posttransplant was 4.4years. Screening-detected dnDSA was associated with an increased risk of rejection within 3years, microvascular inflammation, and C4d staining on a 2-year protocol biopsy. In a Cox proportional hazards regression, screening-detected dnDSA was not associated with time to 30% decline in estimated glomerular filtration rate (adjusted hazard ratio, 0.88; 95% confidence interval [CI], 0.30-2.00; P =0.598) or graft loss. dnDSA first detected on for-cause testing was associated with a 2.8 times increased risk of decline in graft function (95% CI, 1.08-7.27; P =0.034) and a 7.34 times increased risk of graft loss (95% CI, 1.37-39.23 P =0.020) compared with those who did not develop dnDSA. Conclusions The clinical setting in which dnDSA is first detected impacts the association between dnDSA and graft function. Further research is needed to clarify the role of dnDSA screening in pediatric kidney transplantation." @default.
• W2805349718 created "2018-06-13" @default.
• W2805349718 creator A5002649518 @default.
• W2805349718 creator A5007699190 @default.
• W2805349718 creator A5011996440 @default.
• W2805349718 creator A5016958524 @default.
• W2805349718 creator A5042453734 @default.
• W2805349718 creator A5043666719 @default.
• W2805349718 creator A5053497191 @default.
• W2805349718 creator A5057486621 @default.
• W2805349718 date "2018-12-01" @default.
• W2805349718 modified "2023-10-04" @default.
• W2805349718 title "Donor-specific Antibody Surveillance and Graft Outcomes in Pediatric Kidney Transplant Recipients" @default.
• W2805349718 cites W1486598251 @default.
• W2805349718 cites W1499906725 @default.
• W2805349718 cites W1505723685 @default.
• W2805349718 cites W1526250374 @default.
• W2805349718 cites W1556101114 @default.
• W2805349718 cites W1595138225 @default.
• W2805349718 cites W1973641497 @default.
• W2805349718 cites W1995815906 @default.
• W2805349718 cites W1999561028 @default.
• W2805349718 cites W2010525793 @default.
• W2805349718 cites W2010792025 @default.
• W2805349718 cites W2020806054 @default.
• W2805349718 cites W2023133945 @default.
• W2805349718 cites W2026703386 @default.
• W2805349718 cites W2042021216 @default.
• W2805349718 cites W2047292563 @default.
• W2805349718 cites W2050330669 @default.
• W2805349718 cites W2067090279 @default.
• W2805349718 cites W2067863998 @default.
• W2805349718 cites W2070761004 @default.
• W2805349718 cites W2085300160 @default.
• W2805349718 cites W2085930917 @default.
• W2805349718 cites W2087505884 @default.
• W2805349718 cites W2092382141 @default.
• W2805349718 cites W2097840617 @default.
• W2805349718 cites W2115660072 @default.
• W2805349718 cites W2122855609 @default.
• W2805349718 cites W2146942876 @default.
• W2805349718 cites W2153871540 @default.
• W2805349718 cites W2155965977 @default.
• W2805349718 cites W2160215044 @default.
• W2805349718 cites W2227860561 @default.
• W2805349718 cites W2298732643 @default.
• W2805349718 cites W2607031541 @default.
• W2805349718 doi "https://doi.org/10.1097/tp.0000000000002310" @default.
• W2805349718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6249093" @default.
• W2805349718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29863579" @default.
• W2805349718 hasPublicationYear "2018" @default.
• W2805349718 type Work @default.
• W2805349718 sameAs 2805349718 @default.
• W2805349718 citedByCount "12" @default.
• W2805349718 countsByYear W28053497182019 @default.
• W2805349718 countsByYear W28053497182020 @default.
• W2805349718 countsByYear W28053497182021 @default.
• W2805349718 countsByYear W28053497182022 @default.
• W2805349718 countsByYear W28053497182023 @default.
• W2805349718 crossrefType "journal-article" @default.
• W2805349718 hasAuthorship W2805349718A5002649518 @default.
• W2805349718 hasAuthorship W2805349718A5007699190 @default.
• W2805349718 hasAuthorship W2805349718A5011996440 @default.
• W2805349718 hasAuthorship W2805349718A5016958524 @default.
• W2805349718 hasAuthorship W2805349718A5042453734 @default.
• W2805349718 hasAuthorship W2805349718A5043666719 @default.
• W2805349718 hasAuthorship W2805349718A5053497191 @default.
• W2805349718 hasAuthorship W2805349718A5057486621 @default.
• W2805349718 hasBestOaLocation W28053497181 @default.
• W2805349718 hasConcept C126322002 @default.
• W2805349718 hasConcept C126894567 @default.
• W2805349718 hasConcept C159641895 @default.
• W2805349718 hasConcept C207103383 @default.
• W2805349718 hasConcept C2775934546 @default.
• W2805349718 hasConcept C2780091579 @default.
• W2805349718 hasConcept C2780303639 @default.
• W2805349718 hasConcept C2911091166 @default.
• W2805349718 hasConcept C2994498544 @default.
• W2805349718 hasConcept C3019514911 @default.
• W2805349718 hasConcept C44249647 @default.
• W2805349718 hasConcept C71924100 @default.
• W2805349718 hasConcept C90924648 @default.
• W2805349718 hasConceptScore W2805349718C126322002 @default.
• W2805349718 hasConceptScore W2805349718C126894567 @default.
• W2805349718 hasConceptScore W2805349718C159641895 @default.
• W2805349718 hasConceptScore W2805349718C207103383 @default.
• W2805349718 hasConceptScore W2805349718C2775934546 @default.
• W2805349718 hasConceptScore W2805349718C2780091579 @default.
• W2805349718 hasConceptScore W2805349718C2780303639 @default.
• W2805349718 hasConceptScore W2805349718C2911091166 @default.
• W2805349718 hasConceptScore W2805349718C2994498544 @default.
• W2805349718 hasConceptScore W2805349718C3019514911 @default.
• W2805349718 hasConceptScore W2805349718C44249647 @default.
• W2805349718 hasConceptScore W2805349718C71924100 @default.
• W2805349718 hasConceptScore W2805349718C90924648 @default.
• W2805349718 hasIssue "12" @default.
• W2805349718 hasLocation W28053497181 @default.
• W2805349718 hasLocation W28053497182 @default.

• next