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- W2805352006 endingPage "218" @default.
- W2805352006 startingPage "218" @default.
- W2805352006 abstract "Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs’ physiological functions. Chronic, low-grade inflammation and oxidative stress—hallmarks of CKD—are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling." @default.
- W2805352006 created "2018-06-13" @default.
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- W2805352006 creator A5076711449 @default.
- W2805352006 date "2018-05-29" @default.
- W2805352006 modified "2023-09-30" @default.
- W2805352006 title "The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function" @default.
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