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- W2805371262 abstract "Abstract Moraxella catarrhalis is a common human respiratory tract pathogen. Its virulence factors associated with whole bacteria or outer membrane vesicles (OMVs) aid infection, colonization and may induce specific antibodies. To investigate pathogen-host interactions, we applied integrated bioinformatic and immunoproteomic (2D-electrophoresis, immunoblotting, LC-MS/MS) approaches. We showed that OMV proteins engaged exclusively in complement evasion and colonization strategies, but not those involved in iron transport and metabolism, are major targets for cross-reacting antibodies produced against phylogenetically divergent M. catarrhalis strains. The analysis of 31 complete genomes of M. catarrhalis and other Moraxella revealed that OMV protein-coding genes belong to 64 orthologous groups, five of which are restricted to M. catarrhalis . This species showed a two-fold increase in the number of OMV protein-coding genes relative to its ancestors and animal-pathogenic Moraxella . The appearance of specific OMV factors and the increase in OMV-associated virulence proteins during M. catarrhalis evolution is an interesting example of pathogen adaptation to optimize colonization. This precisely targeted cross-reactive immunity against M. catarrhalis may be an important strategy of host defences to counteract this phenomenon. We demonstrate that cross-reactivity is closely associated with the anti-virulent antibody repertoire which we have linked with adaptation of this pathogen to the host." @default.
- W2805371262 created "2018-06-13" @default.
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- W2805371262 date "2018-03-21" @default.
- W2805371262 modified "2023-10-12" @default.
- W2805371262 title "Virulence factors of Moraxella catarrhalis outer membrane vesicles are major targets for cross-reactive antibodies and have adapted during evolution" @default.
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- W2805371262 doi "https://doi.org/10.1038/s41598-018-23029-7" @default.
- W2805371262 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5862889" @default.
- W2805371262 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29563531" @default.
- W2805371262 hasPublicationYear "2018" @default.
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