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- W2805378833 abstract "Cenderitide is a novel designer natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide was engineered to co-activate the two NP receptors, particulate guanylyl cyclase (pGC)-A and pGC-B. The rationale for its design was to achieve the renal-enhancing and anti-fibrotic properties of dual receptor activation, but without clinically significant hypotension. Here, we review the biology of the NPs and the rationale for their use in heart failure. Most importantly, we present the key studies related to the discovery of Cenderitide. Finally, we review the key clinical studies that have advanced this first-in-class dual NP receptor activator for heart failure." @default.
- W2805378833 created "2018-06-13" @default.
- W2805378833 creator A5014193048 @default.
- W2805378833 creator A5033121898 @default.
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- W2805378833 date "2019-04-01" @default.
- W2805378833 modified "2023-10-14" @default.
- W2805378833 title "Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide" @default.
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- W2805378833 doi "https://doi.org/10.1016/j.ijcard.2018.06.002" @default.
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