FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805384400> ?p ?o ?g. }

• W2805384400 abstract "Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases. The ICAM-1-related (ICR) long non-coding RNA stabilizes ICAM-1 transcript, increasing protein expression. However, studies of ICR involvement in disease have been limited as the promoter is uncharacterized. To address this issue, we undertook a comprehensive in silico analysis of the human ICR gene promoter region. We used genomic evolutionary rate profiling to identify a 115 base pair (bp) sequence within 500 bp upstream of the transcription start site of the annotated human ICR gene that was conserved across 25 eutherian genomes. A second constrained sequence upstream of the orthologous mouse gene (68 bp; conserved across 27 Eutherian genomes including human) was also discovered. Searching these elements identified 33 matrices predictive of binding sites for transcription factors known to be responsive to a broad range of pathological stimuli, including hypoxia, and metabolic and inflammatory proteins. Five phenotype-associated single nucleotide polymorphisms (SNPs) in the immediate vicinity of these elements included four SNPs (i.e. rs2569693, rs281439, rs281440 and rs11575074) predicted to impact binding motifs of transcription factors, and thus the expression of ICR and ICAM-1 genes, with potential to influence disease susceptibility. We verified that human retinal endothelial cells expressed ICR, and observed induction of expression by tumor necrosis factor-α." @default.
• W2805384400 created "2018-06-13" @default.
• W2805384400 creator A5033621412 @default.
• W2805384400 creator A5035952377 @default.
• W2805384400 creator A5036578104 @default.
• W2805384400 creator A5039788287 @default.
• W2805384400 creator A5046162660 @default.
• W2805384400 creator A5055467340 @default.
• W2805384400 creator A5066108340 @default.
• W2805384400 date "2018-05-09" @default.
• W2805384400 modified "2023-10-07" @default.
• W2805384400 title "ICAM-1-related long non-coding RNA: promoter analysis and expression in human retinal endothelial cells" @default.
• W2805384400 cites W15447132 @default.
• W2805384400 cites W1572664742 @default.
• W2805384400 cites W1966593909 @default.
• W2805384400 cites W1968427910 @default.
• W2805384400 cites W1980016239 @default.
• W2805384400 cites W2031945713 @default.
• W2805384400 cites W2038473742 @default.
• W2805384400 cites W2048671492 @default.
• W2805384400 cites W2083238137 @default.
• W2805384400 cites W2084991860 @default.
• W2805384400 cites W2090271599 @default.
• W2805384400 cites W2103209061 @default.
• W2805384400 cites W2105044812 @default.
• W2805384400 cites W2107277218 @default.
• W2805384400 cites W2122732537 @default.
• W2805384400 cites W2130171029 @default.
• W2805384400 cites W2143051124 @default.
• W2805384400 cites W2148056478 @default.
• W2805384400 cites W2153550523 @default.
• W2805384400 cites W2192080449 @default.
• W2805384400 cites W2209360008 @default.
• W2805384400 cites W2259938310 @default.
• W2805384400 cites W2367702238 @default.
• W2805384400 cites W2769028088 @default.
• W2805384400 cites W2776522050 @default.
• W2805384400 cites W4245023496 @default.
• W2805384400 cites W4250359879 @default.
• W2805384400 doi "https://doi.org/10.1186/s13104-018-3384-8" @default.
• W2805384400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5944171" @default.
• W2805384400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29743093" @default.
• W2805384400 hasPublicationYear "2018" @default.
• W2805384400 type Work @default.
• W2805384400 sameAs 2805384400 @default.
• W2805384400 citedByCount "4" @default.
• W2805384400 countsByYear W28053844002021 @default.
• W2805384400 countsByYear W28053844002022 @default.
• W2805384400 countsByYear W28053844002023 @default.
• W2805384400 crossrefType "journal-article" @default.
• W2805384400 hasAuthorship W2805384400A5033621412 @default.
• W2805384400 hasAuthorship W2805384400A5035952377 @default.
• W2805384400 hasAuthorship W2805384400A5036578104 @default.
• W2805384400 hasAuthorship W2805384400A5039788287 @default.
• W2805384400 hasAuthorship W2805384400A5046162660 @default.
• W2805384400 hasAuthorship W2805384400A5055467340 @default.
• W2805384400 hasAuthorship W2805384400A5066108340 @default.
• W2805384400 hasBestOaLocation W28053844001 @default.
• W2805384400 hasConcept C101762097 @default.
• W2805384400 hasConcept C104317684 @default.
• W2805384400 hasConcept C141231307 @default.
• W2805384400 hasConcept C150194340 @default.
• W2805384400 hasConcept C197077220 @default.
• W2805384400 hasConcept C2775905019 @default.
• W2805384400 hasConcept C54355233 @default.
• W2805384400 hasConcept C86339819 @default.
• W2805384400 hasConcept C86803240 @default.
• W2805384400 hasConcept C91779695 @default.
• W2805384400 hasConceptScore W2805384400C101762097 @default.
• W2805384400 hasConceptScore W2805384400C104317684 @default.
• W2805384400 hasConceptScore W2805384400C141231307 @default.
• W2805384400 hasConceptScore W2805384400C150194340 @default.
• W2805384400 hasConceptScore W2805384400C197077220 @default.
• W2805384400 hasConceptScore W2805384400C2775905019 @default.
• W2805384400 hasConceptScore W2805384400C54355233 @default.
• W2805384400 hasConceptScore W2805384400C86339819 @default.
• W2805384400 hasConceptScore W2805384400C86803240 @default.
• W2805384400 hasConceptScore W2805384400C91779695 @default.
• W2805384400 hasFunder F4320320498 @default.
• W2805384400 hasFunder F4320320977 @default.
• W2805384400 hasFunder F4320334704 @default.
• W2805384400 hasFunder F4320334705 @default.
• W2805384400 hasIssue "1" @default.
• W2805384400 hasLocation W28053844001 @default.
• W2805384400 hasLocation W28053844002 @default.
• W2805384400 hasLocation W28053844003 @default.
• W2805384400 hasLocation W28053844004 @default.
• W2805384400 hasLocation W28053844005 @default.
• W2805384400 hasOpenAccess W2805384400 @default.
• W2805384400 hasPrimaryLocation W28053844001 @default.
• W2805384400 hasRelatedWork W1999232590 @default.
• W2805384400 hasRelatedWork W2034805612 @default.
• W2805384400 hasRelatedWork W2091106247 @default.
• W2805384400 hasRelatedWork W2093909589 @default.
• W2805384400 hasRelatedWork W2131930552 @default.
• W2805384400 hasRelatedWork W2158182153 @default.
• W2805384400 hasRelatedWork W2165812603 @default.
• W2805384400 hasRelatedWork W2204679973 @default.
• W2805384400 hasRelatedWork W2399616370 @default.
• W2805384400 hasRelatedWork W4235753716 @default.

• next