Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805386160> ?p ?o ?g. }
- W2805386160 abstract "Abstract Alzheimer’s Disease (AD) is the most common cause of dementia in the elderly. Centenarians – reaching the age of >100 years while maintaining good cognitive skills – seemingly have unique biological features allowing healthy aging and protection from dementia. Here, we studied the expression of SIRT1 along with miR-132 and miR-212, two microRNAs known to regulate SIRT1 , in lymphoblastoid cell lines (LCLs) from 45 healthy donors aged 21 to 105 years and 24 AD patients, and in postmortem olfactory bulb and hippocampus tissues from 14 AD patients and 20 age-matched non-demented individuals. We observed 4.0-fold (P = 0.001) lower expression of SIRT1 , and correspondingly higher expression of miR-132 (1.7-fold; P = 0.014) and miR-212 (2.1-fold; P = 0.036), in LCLs from AD patients compared with age-matched healthy controls. Additionally, SIRT1 expression was 2.2-fold (P = 0.001) higher in centenarian LCLs compared with LCLs from individuals aged 56–82 years; while centenarian LCLs miR-132 and miR-212 indicated 7.6-fold and 4.1-fold lower expression, respectively. Correlations of SIRT1 , miR-132 and miR-212 expression with cognitive scores were observed for AD patient-derived LCLs and postmortem AD olfactory bulb and hippocampus tissues, suggesting that higher SIRT1 expression, possibly mediated by lower miR-132 and miR-212, may protect aged individuals from dementia and is reflected in their peripheral tissues." @default.
- W2805386160 created "2018-06-13" @default.
- W2805386160 creator A5000083928 @default.
- W2805386160 creator A5006745559 @default.
- W2805386160 creator A5014860872 @default.
- W2805386160 creator A5039498975 @default.
- W2805386160 creator A5043469490 @default.
- W2805386160 creator A5053853143 @default.
- W2805386160 creator A5077963659 @default.
- W2805386160 creator A5079660119 @default.
- W2805386160 creator A5080282776 @default.
- W2805386160 creator A5081024990 @default.
- W2805386160 creator A5084886623 @default.
- W2805386160 date "2018-05-31" @default.
- W2805386160 modified "2023-10-17" @default.
- W2805386160 title "SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease" @default.
- W2805386160 cites W1486176185 @default.
- W2805386160 cites W1501752213 @default.
- W2805386160 cites W1870776631 @default.
- W2805386160 cites W1882821985 @default.
- W2805386160 cites W1924808185 @default.
- W2805386160 cites W1973083723 @default.
- W2805386160 cites W1980677407 @default.
- W2805386160 cites W1985308585 @default.
- W2805386160 cites W1986093216 @default.
- W2805386160 cites W1986915486 @default.
- W2805386160 cites W1989810429 @default.
- W2805386160 cites W1996915289 @default.
- W2805386160 cites W2008166785 @default.
- W2805386160 cites W2010304763 @default.
- W2805386160 cites W2016148530 @default.
- W2805386160 cites W2021227878 @default.
- W2805386160 cites W2021998309 @default.
- W2805386160 cites W2042161313 @default.
- W2805386160 cites W2044700058 @default.
- W2805386160 cites W2050224211 @default.
- W2805386160 cites W2052572393 @default.
- W2805386160 cites W2054552572 @default.
- W2805386160 cites W2061077538 @default.
- W2805386160 cites W2062947765 @default.
- W2805386160 cites W2064063710 @default.
- W2805386160 cites W2073988218 @default.
- W2805386160 cites W2080137338 @default.
- W2805386160 cites W2088381487 @default.
- W2805386160 cites W2091410656 @default.
- W2805386160 cites W2093146807 @default.
- W2805386160 cites W2097948853 @default.
- W2805386160 cites W2099535442 @default.
- W2805386160 cites W2100978260 @default.
- W2805386160 cites W2104379885 @default.
- W2805386160 cites W2110065044 @default.
- W2805386160 cites W2111740231 @default.
- W2805386160 cites W2115476694 @default.
- W2805386160 cites W2115779804 @default.
- W2805386160 cites W2124680844 @default.
- W2805386160 cites W2128228199 @default.
- W2805386160 cites W2152907424 @default.
- W2805386160 cites W2161678021 @default.
- W2805386160 cites W2162961904 @default.
- W2805386160 cites W2167933097 @default.
- W2805386160 cites W2174497040 @default.
- W2805386160 cites W2181195518 @default.
- W2805386160 cites W2191798539 @default.
- W2805386160 cites W2239556028 @default.
- W2805386160 cites W2255215236 @default.
- W2805386160 cites W2274582236 @default.
- W2805386160 cites W2528861630 @default.
- W2805386160 cites W2528924905 @default.
- W2805386160 cites W2542225333 @default.
- W2805386160 cites W2569925267 @default.
- W2805386160 cites W2580127280 @default.
- W2805386160 cites W2594801926 @default.
- W2805386160 cites W2596337497 @default.
- W2805386160 cites W2603128153 @default.
- W2805386160 cites W2608932227 @default.
- W2805386160 cites W2611895657 @default.
- W2805386160 cites W2740928369 @default.
- W2805386160 cites W2765655550 @default.
- W2805386160 cites W2766021197 @default.
- W2805386160 cites W2790231974 @default.
- W2805386160 cites W283604438 @default.
- W2805386160 cites W3014251530 @default.
- W2805386160 cites W32204808 @default.
- W2805386160 doi "https://doi.org/10.1038/s41598-018-26547-6" @default.
- W2805386160 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5981646" @default.
- W2805386160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29855513" @default.
- W2805386160 hasPublicationYear "2018" @default.
- W2805386160 type Work @default.
- W2805386160 sameAs 2805386160 @default.
- W2805386160 citedByCount "79" @default.
- W2805386160 countsByYear W28053861602018 @default.
- W2805386160 countsByYear W28053861602019 @default.
- W2805386160 countsByYear W28053861602020 @default.
- W2805386160 countsByYear W28053861602021 @default.
- W2805386160 countsByYear W28053861602022 @default.
- W2805386160 countsByYear W28053861602023 @default.
- W2805386160 crossrefType "journal-article" @default.
- W2805386160 hasAuthorship W2805386160A5000083928 @default.
- W2805386160 hasAuthorship W2805386160A5006745559 @default.
- W2805386160 hasAuthorship W2805386160A5014860872 @default.