Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805395704> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2805395704 endingPage "227" @default.
- W2805395704 startingPage "220" @default.
- W2805395704 abstract "Coronary heart disease is a vital cause of morbidity and mortality worldwide, and calcium channel blockers (CCBs) are important drugs that can be used to treat cardiovascular diseases. Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, is widely used as an emergency drug for coronary heart disease therapy. However, understanding its potential mechanism in intracellular calcium concentration ([Ca2+]i) modulation remains a challenge. To identify the active pharmacological ingredients (APIs) and reveal a novel combination therapy for ameliorating cardiovascular diseases, the ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) combined with a dual-luciferase reporter [Ca2+]i assay system was applied. Ligustrazine, ferulic acid, senkyunolide I, senkyunolide A and ligustilide were identified as potential calcium antagonists in SX, and the combination of ligustrazine and senkyunolide A showed synergetic calcium antagonistic activity. Additionally, the synergetic mechanism was further investigated by live-imaging analysis with the Ca2+ indicator fluo-4/AM by monitoring fluorescence changes. Our results indicated that ligustrazine can block voltage-operated Ca2+ channels (VDCCs) effectively and senkyunolide A can exert an inhibition effect mostly on ryanodine receptors (RYRs) and partly on VDCCs. Finally, an arterial ring assay showed that the combination of ligustrazine and senkyunolide A exerted a better vasodilatation function than using any components alone. In this study, we first revealed that a pair of natural APIs in combination acting on VDCCs and RYRs was more effective on vasodilatation by regulating [Ca2+]i." @default.
- W2805395704 created "2018-06-13" @default.
- W2805395704 creator A5021853076 @default.
- W2805395704 creator A5027697968 @default.
- W2805395704 creator A5028253155 @default.
- W2805395704 creator A5077311532 @default.
- W2805395704 creator A5084393924 @default.
- W2805395704 date "2018-08-01" @default.
- W2805395704 modified "2023-10-16" @default.
- W2805395704 title "Searching for synergistic calcium antagonists and novel therapeutic regimens for coronary heart disease therapy from a Traditional Chinese Medicine, Suxiao Jiuxin Pill" @default.
- W2805395704 cites W1552088358 @default.
- W2805395704 cites W1971653362 @default.
- W2805395704 cites W1974986004 @default.
- W2805395704 cites W1984880976 @default.
- W2805395704 cites W2001147671 @default.
- W2805395704 cites W2007939322 @default.
- W2805395704 cites W2010852194 @default.
- W2805395704 cites W2012530660 @default.
- W2805395704 cites W2021471527 @default.
- W2805395704 cites W2024190329 @default.
- W2805395704 cites W2032276855 @default.
- W2805395704 cites W2051083125 @default.
- W2805395704 cites W2059886467 @default.
- W2805395704 cites W2071485917 @default.
- W2805395704 cites W2094254507 @default.
- W2805395704 cites W2094287539 @default.
- W2805395704 cites W2112125919 @default.
- W2805395704 cites W2125590987 @default.
- W2805395704 cites W2134195135 @default.
- W2805395704 cites W2138610459 @default.
- W2805395704 cites W2155842024 @default.
- W2805395704 cites W2158962017 @default.
- W2805395704 cites W2191232576 @default.
- W2805395704 cites W2237463071 @default.
- W2805395704 cites W2345823565 @default.
- W2805395704 cites W2399179803 @default.
- W2805395704 cites W2509007372 @default.
- W2805395704 cites W2619968329 @default.
- W2805395704 cites W2752188926 @default.
- W2805395704 cites W66196800 @default.
- W2805395704 cites W944997399 @default.
- W2805395704 doi "https://doi.org/10.1016/j.jchromb.2018.06.015" @default.
- W2805395704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29908471" @default.
- W2805395704 hasPublicationYear "2018" @default.
- W2805395704 type Work @default.
- W2805395704 sameAs 2805395704 @default.
- W2805395704 citedByCount "28" @default.
- W2805395704 countsByYear W28053957042019 @default.
- W2805395704 countsByYear W28053957042020 @default.
- W2805395704 countsByYear W28053957042021 @default.
- W2805395704 countsByYear W28053957042022 @default.
- W2805395704 countsByYear W28053957042023 @default.
- W2805395704 crossrefType "journal-article" @default.
- W2805395704 hasAuthorship W2805395704A5021853076 @default.
- W2805395704 hasAuthorship W2805395704A5027697968 @default.
- W2805395704 hasAuthorship W2805395704A5028253155 @default.
- W2805395704 hasAuthorship W2805395704A5077311532 @default.
- W2805395704 hasAuthorship W2805395704A5084393924 @default.
- W2805395704 hasConcept C113217602 @default.
- W2805395704 hasConcept C178790620 @default.
- W2805395704 hasConcept C185592680 @default.
- W2805395704 hasConcept C2776999253 @default.
- W2805395704 hasConcept C2911069016 @default.
- W2805395704 hasConcept C519063684 @default.
- W2805395704 hasConcept C71924100 @default.
- W2805395704 hasConcept C85520022 @default.
- W2805395704 hasConcept C98274493 @default.
- W2805395704 hasConceptScore W2805395704C113217602 @default.
- W2805395704 hasConceptScore W2805395704C178790620 @default.
- W2805395704 hasConceptScore W2805395704C185592680 @default.
- W2805395704 hasConceptScore W2805395704C2776999253 @default.
- W2805395704 hasConceptScore W2805395704C2911069016 @default.
- W2805395704 hasConceptScore W2805395704C519063684 @default.
- W2805395704 hasConceptScore W2805395704C71924100 @default.
- W2805395704 hasConceptScore W2805395704C85520022 @default.
- W2805395704 hasConceptScore W2805395704C98274493 @default.
- W2805395704 hasFunder F4320321001 @default.
- W2805395704 hasLocation W28053957041 @default.
- W2805395704 hasLocation W28053957042 @default.
- W2805395704 hasOpenAccess W2805395704 @default.
- W2805395704 hasPrimaryLocation W28053957041 @default.
- W2805395704 hasRelatedWork W2027792047 @default.
- W2805395704 hasRelatedWork W2347406820 @default.
- W2805395704 hasRelatedWork W2348379405 @default.
- W2805395704 hasRelatedWork W2353942876 @default.
- W2805395704 hasRelatedWork W2364065908 @default.
- W2805395704 hasRelatedWork W2369010294 @default.
- W2805395704 hasRelatedWork W2388072877 @default.
- W2805395704 hasRelatedWork W2907942589 @default.
- W2805395704 hasRelatedWork W2950901519 @default.
- W2805395704 hasRelatedWork W3029794887 @default.
- W2805395704 hasVolume "1092" @default.
- W2805395704 isParatext "false" @default.
- W2805395704 isRetracted "false" @default.
- W2805395704 magId "2805395704" @default.
- W2805395704 workType "article" @default.