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• W2805439702 abstract "Advances in Asthma Management Prevention and treatment of asthma exacerbation in childrenBenjamin VolovitzBenjamin VolovitzBenjamin Volovitz has 30 years’ experience in asthma treatment and research. He was a member of several consensus forms for the treatment of asthma in children, and he is active in several international initiatives in the field of asthma. In the asthma research laboratories under his supervision, he investigated the relationship between asthma and viral infection, especially respiratory syncytial virus . He performed many clinical and laboratory studies, and participated in many international studies in acute exacerbation of asthma and in asthma maintenance treatment. His main interest is treatment with inhaled corticosteroids in acute asthma exacerbation, and he has written several reviews on this subject. Another one of his interests is asthma education. He has written a number of reviews on this subject, and has given many lectures in various formats. Each parent is instructed to hear an asthma education discourse on his website (www.volovitz.co.il) before coming with their child for the first visit to his clinic.Search for more papers by this authorPublished Online:1 Feb 2012https://doi.org/10.2217/ebo.11.194AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinkedInReddit View chapterAbstract: Exacerbations of asthma are part of the natural history of asthma, and may also represent a failure of ongoing long-term therapy. In the USA alone, 4.1 million children under 18 years of age suffered from asthma exacerbations [101]. After discharge from the hospital for asthma exacerbation, 57% of children are readmitted with recurrence [1]. Most cases in the pediatric-population can and should be prevented or managed at home, thus obviating the need for hospitalization. References1 Fuhrman C , Delacourt C , De Blic J et al. Hospital admissions for asthma exacerbation in children . Arch. Pediatr. 17 (4) , 366 – 372 (2010) . Crossref, Medline, CAS, Google Scholar2 Bateman ED , Hurd SS , Barnes PJ et al. Global strategy for asthma management and prevention: GINA executive summary . Eur. Respir. J. 31 , 143 – 178 (2008) . Crossref, Medline, CAS, Google Scholar3 Rowe BH , Spooner C , Ducharme FM , Bretzlaff JA , Bota GW . Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database Syst. Rev. (1) , CD002178 (2001) . Medline, Google Scholar4 Zora JA , Zimmerman D , Carey TL . Hypothalamic–pituitary–adrenal axis suppression after short-term, high-dose glucocorticoid therapy in children with asthma. J. Allergy Clin. Immunol. 77 , 9 – 13 (1986) . Crossref, Medline, CAS, Google Scholar5 Volovitz B . Inhaled corticosteroids as rescue medication in asthma exacerbation inchildren. Expert Rev. Clin. Immunol. 4 (6) , 695 – 702 (2008) . Crossref, Medline, CAS, Google Scholar6 Decimo F , Maiello N , Miraglia Del Giudice M , Amelio R , Capristo C , Capristo AF . High-dose inhaled flunisolide versus budesonide in the treatment of acute asthma exacerbations in preschool-age children. Int. J. Immunopathol. Pharmacol. (2) , 363 – 370 (2009) . Crossref, Medline, Google Scholar7 Petersen US , Kava T , Dahle R , Lei Y , Dam N . Budesonide/formoterol maintenance and reliever therapy versus conventional best standard treatment in asthma in an attempted ‘real life’ setting. Clin. Respir. J. 5 (3) , 173 – 182 (2011) . Crossref, Medline, Google Scholar8 Martinez FD , Chinchilli VM , Morgan WJ et al. 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Nebulized dexamethasone versus oral prednisone in the emergency treatment of asthmatic children. Ann. Emerg. Med. 26 , 480 – 486 (1995) . Crossref, Medline, CAS, Google Scholar25 Devidayal , Singhi S , Kumar L , Jayshree M . Efficacy of nebulized budesonide compared to oral prednisolone in acute bronchial asthma. Acta Paediatr. 88 , 835 – 840 (1999) . Crossref, Medline, CAS, Google Scholar26 Matthews EE , Curtis PD , McLain BI , Morris LS , Turbitt ML . Nebulized budesonide versus oral steroid in severe exacerbations of childhood asthma. Acta Paediatr. 88 , 841 – 843 (1999) . Crossref, Medline, CAS, Google Scholar27 Manjra AI , Price J , Lenney W , Hughes S , Barnacle H . Efficacy of nebulized fluticasone propionate compared with oral prednisolone in children with an acute exacerbation of asthma. Respir. Med. 94 , 1206 – 1214 (2000) . Crossref, Medline, CAS, Google Scholar28 Schuh S , Reisman J , Alshehri M et al. A comparison of inhaled fluticasone and oral prednisone for children with severe acute asthma. N. Engl. J. Med. 343 , 689 – 694 (2000) . Crossref, Medline, CAS, Google Scholar29 Milani GK , Rosario , Filho NA , Riedi CA , BC F . Nebulized budesonide to treat acute asthma in children. J. Pediatr. [Rio J.] 80 , 106 – 112 (2004) . Crossref, Google Scholar30 Schuh S , Dick PT , Stephens D et al. High-dose inhaled fluticasone does not replace oral prednisolone in children with mild to moderate acute asthma. Pediatrics 118 , 644 – 650 (2006) . Crossref, Medline, Google Scholar101 Centers for Disease Control and Prevention. www.cdc.gov/ Google Scholar102 Asthma in children. www.volovitz.co.il Google Scholar102 Expert Panel Report 3 (EPR-3). Guidelines for the diagnosis and management of asthma. www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf Google ScholarFiguresReferencesRelatedDetails Advances in Asthma ManagementMetrics Downloaded 28 times History Published online 1 February 2012 Published in print January 2012 Information© Future Medicine Ltd© 2012 Future Medicine LtdPDF download" @default.
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