FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805499967> ?p ?o ?g. }

• W2805499967 abstract "Summary Neuromuscular decline occurs with aging. The neuromuscular junction (NMJ), the interface between motor nerve and muscle, also undergoes age‐related changes. Aging effects on the NMJ components—motor nerve terminal, acetylcholine receptors (AChRs), and nonmyelinating terminal Schwann cells (tSCs)—have not been comprehensively evaluated. Sirtuins delay mammalian aging and increase longevity. Increased hypothalamic Sirt1 expression results in more youthful physiology, but the relationship between NMJ morphology and hypothalamic Sirt1 was previously unknown. In wild‐type mice, all NMJ components showed age‐associated morphological changes with ~80% of NMJs displaying abnormalities by 17 months of age. Aged mice with brain‐specific Sirt1 overexpression (BRASTO) had more youthful NMJ morphologic features compared to controls with increased tSC numbers, increased NMJ innervation, and increased numbers of normal AChRs. Sympathetic NMJ innervation was increased in BRASTO mice. In contrast, hypothalamic‐specific Sirt1 knockdown led to tSC abnormalities, decreased tSC numbers, and more denervated endplates compared to controls. Our data suggest that hypothalamic Sirt1 functions to protect NMJs in skeletal muscle from age‐related changes via sympathetic innervation." @default.
• W2805499967 created "2018-06-13" @default.
• W2805499967 creator A5007696844 @default.
• W2805499967 creator A5012998559 @default.
• W2805499967 creator A5029785125 @default.
• W2805499967 creator A5081413351 @default.
• W2805499967 creator A5088072335 @default.
• W2805499967 date "2018-05-30" @default.
• W2805499967 modified "2023-10-14" @default.
• W2805499967 title "Hypothalamic Sirt1 protects terminal Schwann cells and neuromuscular junctions from age-related morphological changes" @default.
• W2805499967 cites W1506500919 @default.
• W2805499967 cites W1828557676 @default.
• W2805499967 cites W1908219509 @default.
• W2805499967 cites W1964569690 @default.
• W2805499967 cites W1966192867 @default.
• W2805499967 cites W1973871269 @default.
• W2805499967 cites W2018341829 @default.
• W2805499967 cites W2021469683 @default.
• W2805499967 cites W2022879766 @default.
• W2805499967 cites W2023052494 @default.
• W2805499967 cites W2034769638 @default.
• W2805499967 cites W2039794565 @default.
• W2805499967 cites W2044586724 @default.
• W2805499967 cites W2045644095 @default.
• W2805499967 cites W2049003557 @default.
• W2805499967 cites W2049638035 @default.
• W2805499967 cites W2060835545 @default.
• W2805499967 cites W2061077538 @default.
• W2805499967 cites W2082921977 @default.
• W2805499967 cites W2083516925 @default.
• W2805499967 cites W2085808125 @default.
• W2805499967 cites W2091975360 @default.
• W2805499967 cites W2094279273 @default.
• W2805499967 cites W2094457727 @default.
• W2805499967 cites W2094955667 @default.
• W2805499967 cites W2097103188 @default.
• W2805499967 cites W2104007452 @default.
• W2805499967 cites W2104357394 @default.
• W2805499967 cites W2107728347 @default.
• W2805499967 cites W2127810309 @default.
• W2805499967 cites W2128772633 @default.
• W2805499967 cites W2129526746 @default.
• W2805499967 cites W2131042197 @default.
• W2805499967 cites W2156032975 @default.
• W2805499967 cites W2156326705 @default.
• W2805499967 cites W2172132757 @default.
• W2805499967 cites W2223176310 @default.
• W2805499967 cites W2317915246 @default.
• W2805499967 cites W2333271618 @default.
• W2805499967 cites W2340546241 @default.
• W2805499967 cites W2616161821 @default.
• W2805499967 doi "https://doi.org/10.1111/acel.12776" @default.
• W2805499967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6052483" @default.
• W2805499967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29851253" @default.
• W2805499967 hasPublicationYear "2018" @default.
• W2805499967 type Work @default.
• W2805499967 sameAs 2805499967 @default.
• W2805499967 citedByCount "28" @default.
• W2805499967 countsByYear W28054999672019 @default.
• W2805499967 countsByYear W28054999672020 @default.
• W2805499967 countsByYear W28054999672021 @default.
• W2805499967 countsByYear W28054999672022 @default.
• W2805499967 countsByYear W28054999672023 @default.
• W2805499967 crossrefType "journal-article" @default.
• W2805499967 hasAuthorship W2805499967A5007696844 @default.
• W2805499967 hasAuthorship W2805499967A5012998559 @default.
• W2805499967 hasAuthorship W2805499967A5029785125 @default.
• W2805499967 hasAuthorship W2805499967A5081413351 @default.
• W2805499967 hasAuthorship W2805499967A5088072335 @default.
• W2805499967 hasBestOaLocation W28054999671 @default.
• W2805499967 hasConcept C126322002 @default.
• W2805499967 hasConcept C127445978 @default.
• W2805499967 hasConcept C134018914 @default.
• W2805499967 hasConcept C169760540 @default.
• W2805499967 hasConcept C170493617 @default.
• W2805499967 hasConcept C2775912687 @default.
• W2805499967 hasConcept C2777004073 @default.
• W2805499967 hasConcept C2777240379 @default.
• W2805499967 hasConcept C2779959927 @default.
• W2805499967 hasConcept C54355233 @default.
• W2805499967 hasConcept C71924100 @default.
• W2805499967 hasConcept C80161118 @default.
• W2805499967 hasConcept C86803240 @default.
• W2805499967 hasConcept C95444343 @default.
• W2805499967 hasConceptScore W2805499967C126322002 @default.
• W2805499967 hasConceptScore W2805499967C127445978 @default.
• W2805499967 hasConceptScore W2805499967C134018914 @default.
• W2805499967 hasConceptScore W2805499967C169760540 @default.
• W2805499967 hasConceptScore W2805499967C170493617 @default.
• W2805499967 hasConceptScore W2805499967C2775912687 @default.
• W2805499967 hasConceptScore W2805499967C2777004073 @default.
• W2805499967 hasConceptScore W2805499967C2777240379 @default.
• W2805499967 hasConceptScore W2805499967C2779959927 @default.
• W2805499967 hasConceptScore W2805499967C54355233 @default.
• W2805499967 hasConceptScore W2805499967C71924100 @default.
• W2805499967 hasConceptScore W2805499967C80161118 @default.
• W2805499967 hasConceptScore W2805499967C86803240 @default.
• W2805499967 hasConceptScore W2805499967C95444343 @default.
• W2805499967 hasFunder F4320306228 @default.
• W2805499967 hasFunder F4320307047 @default.

• next