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• W2805527440 abstract "Abstract Purpose The aim of this study was to determine the effect of active immunization of interleukin ( IL )‐17A to inhibit B cell functions and monitor the risk of infection in a pristane‐induced lupus mice model. Methods Female Balb/c mice were given a single intraperitoneal injection of 0.5 mL pristane. IL ‐17A was coupled to keyhole limpet hemocyanin ( KLH ) and given to mice in three different doses: D0 (0 μg/mL), D1 (1 μg/ mL ), and D2 (10 μg/ mL ). The vaccine was given three times with 3‐week intervals. At day 42, mice were injected intraperitoneally with methicillin‐resistant Staphylococcus aureus ( MRSA ) and monitored for 3 weeks. Plasma cells proliferation, Th17 and plasma cell percentages were measured by flow cytometry; anti‐ IL ‐17A antibody titers, IL ‐17A, and anti‐double‐stranded DNA (anti‐ds DNA ) levels were measured by enzyme‐linked immunosorbent assay; and MRSA colonization was measured by bacterial counter. Results Anti‐ IL ‐17A antibody titers were significantly higher in D2 compared to D0 ( P = 0.012). Serum IL ‐17A levels were also significantly lower in D2 compared to D0 ( P = 0.000) while Th17 percentages were not significantly different between groups. D2 was also had significantly lower anti‐ds DNA ( P = 0.021), lower plasma cell percentages ( P = 0.000) and lower B cell proliferation rate ( P = 0.001) compared to D0. Analysis for the risk of infection also revealed that D2 did not increase the risk of infection compared to D0 ( P = 0.504). Conclusion Active immunization with IL ‐17A coupled to KLH was able to induce a high titer of neutralizing antibodies against IL ‐17A and inhibit B cell functions without increasing the risk of infection in a pristane‐induced lupus mice model." @default.
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• W2805527440 date "2018-06-01" @default.
• W2805527440 modified "2023-09-30" @default.
• W2805527440 title "Effect of active immunization with IL-17A on B cell function and infection risk in pristane-induced lupus model" @default.
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• W2805527440 doi "https://doi.org/10.1111/1756-185x.13325" @default.
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