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- W2805546496 endingPage "62" @default.
- W2805546496 startingPage "49" @default.
- W2805546496 abstract "The protective function of mucosal HIV-1- or SIV-specific antibodies against viral infection has stimulated extensive studies of their Ig isotype association with differences in specificity and in effector functions. In contrast to many mucosally acquired microbial infections in which the humoral responses are dominated by induction of secretory IgA (S-IgA), HIV-1/SIV infections stimulate vigorous IgG responses in sera as well as in external secretions but low IgA virus-specific antibodies although the total levels of IgA in these fluids remain unaltered. The diminished or even absent IgA responses to HIV-1/SIV and to other mucosal antigens in external secretions and their replacement with IgG is likely to influence the functionality of mucosal barriers and eliminate antiinflammatory effector functions of IgA antibodies. Furthermore, the polymeric character of S-IgA with 4-8 antigen-binding sites, exquisite resistance to proteolysis and anti-inflammatory potential are of great advantage in mucosal protection. The markedly different effector functions of mucosal antibodies of IgG and IgA isotypes must be considered in the design of HIV-1 vaccines to stimulate S-IgA responses at sites of virus entry and IgG responses in the systemic compartment." @default.
- W2805546496 created "2018-06-13" @default.
- W2805546496 creator A5011153203 @default.
- W2805546496 date "2019-04-12" @default.
- W2805546496 modified "2023-10-08" @default.
- W2805546496 title "HIV-1/SIV Humoral Responses in External Secretions" @default.
- W2805546496 cites W112951069 @default.
- W2805546496 cites W1498951716 @default.
- W2805546496 cites W1508733615 @default.
- W2805546496 cites W1528520360 @default.
- W2805546496 cites W1528650603 @default.
- W2805546496 cites W1536777415 @default.
- W2805546496 cites W1568972713 @default.
- W2805546496 cites W1579632014 @default.
- W2805546496 cites W1594804329 @default.
- W2805546496 cites W1606664295 @default.
- W2805546496 cites W1623081601 @default.
- W2805546496 cites W1678848363 @default.
- W2805546496 cites W1761080534 @default.
- W2805546496 cites W1870505889 @default.
- W2805546496 cites W1875884843 @default.
- W2805546496 cites W1909824893 @default.
- W2805546496 cites W1953625602 @default.
- W2805546496 cites W1963752586 @default.
- W2805546496 cites W1964903237 @default.
- W2805546496 cites W1965439127 @default.
- W2805546496 cites W1966975422 @default.
- W2805546496 cites W1968201178 @default.
- W2805546496 cites W1971233211 @default.
- W2805546496 cites W1977839506 @default.
- W2805546496 cites W1978057226 @default.
- W2805546496 cites W1978094300 @default.
- W2805546496 cites W1979166051 @default.
- W2805546496 cites W1981154796 @default.
- W2805546496 cites W1982189917 @default.
- W2805546496 cites W1988398601 @default.
- W2805546496 cites W1988606514 @default.
- W2805546496 cites W1991850017 @default.
- W2805546496 cites W1993472004 @default.
- W2805546496 cites W1993667232 @default.
- W2805546496 cites W1993675648 @default.
- W2805546496 cites W1994492399 @default.
- W2805546496 cites W1995617640 @default.
- W2805546496 cites W1995660211 @default.
- W2805546496 cites W2001049164 @default.
- W2805546496 cites W2003344929 @default.
- W2805546496 cites W2003468923 @default.
- W2805546496 cites W2004703130 @default.
- W2805546496 cites W2005006373 @default.
- W2805546496 cites W2006582130 @default.
- W2805546496 cites W2007884263 @default.
- W2805546496 cites W2008994596 @default.
- W2805546496 cites W2009151161 @default.
- W2805546496 cites W2011826751 @default.
- W2805546496 cites W2012533303 @default.
- W2805546496 cites W2013331408 @default.
- W2805546496 cites W2014120167 @default.
- W2805546496 cites W2015404754 @default.
- W2805546496 cites W2016679437 @default.
- W2805546496 cites W2016862320 @default.
- W2805546496 cites W2019617330 @default.
- W2805546496 cites W2020790415 @default.
- W2805546496 cites W2021217845 @default.
- W2805546496 cites W2023107945 @default.
- W2805546496 cites W2023112191 @default.
- W2805546496 cites W2024287923 @default.
- W2805546496 cites W2024587113 @default.
- W2805546496 cites W2024919877 @default.
- W2805546496 cites W2027993940 @default.
- W2805546496 cites W2028350716 @default.
- W2805546496 cites W2029978945 @default.
- W2805546496 cites W2035276811 @default.
- W2805546496 cites W2036297695 @default.
- W2805546496 cites W2037762980 @default.
- W2805546496 cites W2038216680 @default.
- W2805546496 cites W2041424225 @default.
- W2805546496 cites W2042411936 @default.
- W2805546496 cites W2043118540 @default.
- W2805546496 cites W2043409853 @default.
- W2805546496 cites W2045289859 @default.
- W2805546496 cites W2045757655 @default.
- W2805546496 cites W2046966195 @default.
- W2805546496 cites W2047422912 @default.
- W2805546496 cites W2048624173 @default.
- W2805546496 cites W2050610603 @default.
- W2805546496 cites W2052172534 @default.
- W2805546496 cites W2054200929 @default.
- W2805546496 cites W2055522639 @default.
- W2805546496 cites W2057023184 @default.
- W2805546496 cites W2057899448 @default.
- W2805546496 cites W2058368107 @default.
- W2805546496 cites W2058632331 @default.
- W2805546496 cites W2060119188 @default.
- W2805546496 cites W2060620904 @default.
- W2805546496 cites W2061949672 @default.
- W2805546496 cites W2062936833 @default.
- W2805546496 cites W2063789804 @default.
- W2805546496 cites W2065598559 @default.