FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805577315> ?p ?o ?g. }

• W2805577315 endingPage "946" @default.
• W2805577315 startingPage "927" @default.
• W2805577315 abstract "Ischemic Heart Disease (IHD) remains the developed world’s number one killer. The improved survival from Acute Myocardial Infarction (AMI) and the progressive aging of western population brought to an increased incidence of chronic Heart Failure (HF), which assumed epidemic proportions nowadays. Except for heart transplantation, all treatments for HF should be considered palliative because none of the current therapies can reverse myocardial degeneration responsible for HF syndrome. To stop the HF epidemic will ultimately require protocols to reduce the progressive cardiomyocyte (CM) loss and to foster their regeneration. It is now generally accepted that mammalian CMs renew throughout life. However, this endogenous regenerative reservoir is insufficient to repair the extensive damage produced by AMI/IHD while the source and degree of CM turnover remains strongly disputed. Independent groups have convincingly shown that the adult myocardium harbors bona-fide tissue specific cardiac stem cells (CSCs). Unfortunately, recent reports have challenged the identity and the endogenous myogenic capacity of the c-kit expressing CSCs. This has hampered progress and unless this conflict is settled, clinical tests of repair/regenerative protocols are unlikely to provide convincing answers about their clinical potential. Here we review recent data that have eventually clarified the specific phenotypic identity of true multipotent CSCs. These cells when coaxed by embryonic cardiac morphogens undergo a precisely orchestrated myogenic commitment process robustly generating bona-fide functional cardiomyocytes. These data should set the path for the revival of further investigation untangling the regenerative biology of adult CSCs to harness their potential for HF prevention and treatment." @default.
• W2805577315 created "2018-06-13" @default.
• W2805577315 creator A5006994942 @default.
• W2805577315 creator A5025808462 @default.
• W2805577315 creator A5046040897 @default.
• W2805577315 creator A5063747611 @default.
• W2805577315 creator A5072326352 @default.
• W2805577315 creator A5077030565 @default.
• W2805577315 creator A5077265250 @default.
• W2805577315 date "2018-04-18" @default.
• W2805577315 modified "2023-09-24" @default.
• W2805577315 title "Molecular basis of functional myogenic specification of<i>Bona Fide</i>multipotent adult cardiac stem cells" @default.
• W2805577315 cites W117649874 @default.
• W2805577315 cites W1255140582 @default.
• W2805577315 cites W1542955217 @default.
• W2805577315 cites W1585077536 @default.
• W2805577315 cites W1760771044 @default.
• W2805577315 cites W180606804 @default.
• W2805577315 cites W1807741646 @default.
• W2805577315 cites W1864063551 @default.
• W2805577315 cites W1905616988 @default.
• W2805577315 cites W1925728463 @default.
• W2805577315 cites W1963756072 @default.
• W2805577315 cites W1965271063 @default.
• W2805577315 cites W1965979634 @default.
• W2805577315 cites W1970291858 @default.
• W2805577315 cites W1971671142 @default.
• W2805577315 cites W1971858639 @default.
• W2805577315 cites W1973577066 @default.
• W2805577315 cites W1974033361 @default.
• W2805577315 cites W1977025496 @default.
• W2805577315 cites W1978017776 @default.
• W2805577315 cites W1981761127 @default.
• W2805577315 cites W1985311481 @default.
• W2805577315 cites W1986506996 @default.
• W2805577315 cites W1986821244 @default.
• W2805577315 cites W1990154686 @default.
• W2805577315 cites W1991014863 @default.
• W2805577315 cites W1991177905 @default.
• W2805577315 cites W1993932646 @default.
• W2805577315 cites W1996380574 @default.
• W2805577315 cites W1998650056 @default.
• W2805577315 cites W1999330214 @default.
• W2805577315 cites W2000519963 @default.
• W2805577315 cites W2007662760 @default.
• W2805577315 cites W2008016893 @default.
• W2805577315 cites W2009244520 @default.
• W2805577315 cites W2009527263 @default.
• W2805577315 cites W2009682316 @default.
• W2805577315 cites W2010368308 @default.
• W2805577315 cites W2010417854 @default.
• W2805577315 cites W2012885719 @default.
• W2805577315 cites W2019562841 @default.
• W2805577315 cites W2020857408 @default.
• W2805577315 cites W2021050536 @default.
• W2805577315 cites W2021110745 @default.
• W2805577315 cites W2021574137 @default.
• W2805577315 cites W2022620053 @default.
• W2805577315 cites W2024581871 @default.
• W2805577315 cites W2025239125 @default.
• W2805577315 cites W2025868093 @default.
• W2805577315 cites W2026749151 @default.
• W2805577315 cites W2027134089 @default.
• W2805577315 cites W2028036560 @default.
• W2805577315 cites W2028399935 @default.
• W2805577315 cites W2033360354 @default.
• W2805577315 cites W2036795046 @default.
• W2805577315 cites W2039273130 @default.
• W2805577315 cites W2039396493 @default.
• W2805577315 cites W2041119309 @default.
• W2805577315 cites W2041668737 @default.
• W2805577315 cites W2043362452 @default.
• W2805577315 cites W2044953345 @default.
• W2805577315 cites W2046027917 @default.
• W2805577315 cites W2048692770 @default.
• W2805577315 cites W2050530324 @default.
• W2805577315 cites W2055323054 @default.
• W2805577315 cites W2056359927 @default.
• W2805577315 cites W2056483214 @default.
• W2805577315 cites W2059134148 @default.
• W2805577315 cites W2059984016 @default.
• W2805577315 cites W2060362902 @default.
• W2805577315 cites W2061991201 @default.
• W2805577315 cites W2065171831 @default.
• W2805577315 cites W2065322055 @default.
• W2805577315 cites W2067009965 @default.
• W2805577315 cites W2068303498 @default.
• W2805577315 cites W2069519394 @default.
• W2805577315 cites W2070154483 @default.
• W2805577315 cites W2070772918 @default.
• W2805577315 cites W2071765960 @default.
• W2805577315 cites W2071841171 @default.
• W2805577315 cites W2072004228 @default.
• W2805577315 cites W2075401648 @default.
• W2805577315 cites W2075670261 @default.
• W2805577315 cites W2078215784 @default.
• W2805577315 cites W2080539468 @default.
• W2805577315 cites W2081911624 @default.

• next