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- W2805582314 abstract "Objective: to evaluate the development of cardiotoxicity in patients with triple negative breast cancer with or without arterial hypertension (AH) during anthracycline chemotherapy Design and method: 70 women [mean age 48.6 ± 13.3yrs] with triple negative breast cancer were enrolled. Echocardiography, including 2D Speckle Tracking Imaging, was performed before and after 8 weeks of chemotherapy with doxorubicin, cisplatin, paclitaxel. Left ventricular ejection fraction (LVEF) (the biplane Simpson‘s method) and global longitudinal strain (GLS) [mean normal GLS of– 22.1 ± 1.8] were analyzed. Patients were divided into 2 gr.: gr. 1 - with AH (n = 18) and gr. 2 -without AH (n = 52). Results: Before chemotherapy in gr. 1 GLS was lower than the normal value (– 19.1 ± 2.8% vs – 22.1 ± 1.8 %) (p < 0.05) and lower than in the gr. 2 [– 19.1 ± 2.8% vs -20.0 ± 2.8% (n.s.)]. After chemotherapy in all patients decrease of GLS was observed (from – 20.0 ± 2.8 % to – 18.5 ± 2.9 %) (p < 0.05) and in both grs: in gr. 1 from – 19.1 ± 2.8 % to – 16.4 ± 3.8 % (p < 0.05), gr.2 from – 20.0 ± 2.8% to -– 19.2 ± 2.4 % (p < 0.05), however LVEF decreased, but remained within normal values. Conclusions: Initially GLS was lower than the normal value in patients with AH and breast cancer. Patients with AH and breast cancer, receiving anthracycline chemotherapy constitute the risk group of cardiotoxicity. Thus, patients with AH and breast cancer must be observed by a cardiologist and an oncologist." @default.
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- W2805582314 date "2018-06-01" @default.
- W2805582314 modified "2023-09-25" @default.
- W2805582314 title "EARLY MARKERS OF CARDIOTOXICITY IN PATIENTS WITH BREAST CANCER WITH OR WITHOUT ARTERIAL HYPERTENSION" @default.
- W2805582314 doi "https://doi.org/10.1097/01.hjh.0000539118.98065.f6" @default.
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