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- W2805654492 abstract "The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. Graphene’s peculiar properties can cause various cellular changes, but the underlying mechanisms remain unclear. Here, we show that single-layer graphene increases neuronal firing by altering membrane-associated functions in cultured cells. Graphene tunes the distribution of extracellular ions at the interface with neurons, a key regulator of neuronal excitability. The resulting biophysical changes in the membrane include stronger potassium ion currents, with a shift in the fraction of neuronal firing phenotypes from adapting to tonically firing. By using experimental and theoretical approaches, we hypothesize that the graphene–ion interactions that are maximized when single-layer graphene is deposited on electrically insulating substrates are crucial to these effects. Single-layer graphene increases neuron excitability and firing activity by influencing the distribution of potassium ions at the cellular interface." @default.
- W2805654492 created "2018-06-13" @default.
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- W2805654492 date "2018-06-11" @default.
- W2805654492 modified "2023-10-09" @default.
- W2805654492 title "Single-layer graphene modulates neuronal communication and augments membrane ion currents" @default.
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- W2805654492 doi "https://doi.org/10.1038/s41565-018-0163-6" @default.
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