FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805662486> ?p ?o ?g. }

• W2805662486 endingPage "k2022" @default.
• W2805662486 startingPage "k2022" @default.
• W2805662486 abstract "<h3>Abstract</h3> <h3>Objectives</h3> To determine whether more years spent in education is a causal risk factor for myopia, or whether myopia is a causal risk factor for more years in education. <h3>Design</h3> Bidirectional, two sample mendelian randomisation study. <h3>Setting</h3> Publically available genetic data from two consortiums applied to a large, independent population cohort. Genetic variants used as proxies for myopia and years of education were derived from two large genome wide association studies: 23andMe and Social Science Genetic Association Consortium (SSGAC), respectively. <h3>Participants</h3> 67 798 men and women from England, Scotland, and Wales in the UK Biobank cohort with available information for years of completed education and refractive error. <h3>Main outcome measures</h3> Mendelian randomisation analyses were performed in two directions: the first exposure was the genetic predisposition to myopia, measured with 44 genetic variants strongly associated with myopia in 23andMe, and the outcome was years in education; and the second exposure was the genetic predisposition to higher levels of education, measured with 69 genetic variants from SSGAC, and the outcome was refractive error. <h3>Results</h3> Conventional regression analyses of the observational data suggested that every additional year of education was associated with a more myopic refractive error of −0.18 dioptres/y (95% confidence interval −0.19 to −0.17; P<2e-16). Mendelian randomisation analyses suggested the true causal effect was even stronger: −0.27 dioptres/y (−0.37 to −0.17; P=4e-8). By contrast, there was little evidence to suggest myopia affected education (years in education per dioptre of refractive error −0.008 y/dioptre, 95% confidence interval −0.041 to 0.025, P=0.6). Thus, the cumulative effect of more years in education on refractive error means that a university graduate from the United Kingdom with 17 years of education would, on average, be at least −1 dioptre more myopic than someone who left school at age 16 (with 12 years of education). Myopia of this magnitude would be sufficient to necessitate the use of glasses for driving. Sensitivity analyses showed minimal evidence for genetic confounding that could have biased the causal effect estimates. <h3>Conclusions</h3> This study shows that exposure to more years in education contributes to the rising prevalence of myopia. Increasing the length of time spent in education may inadvertently increase the prevalence of myopia and potential future visual disability." @default.
• W2805662486 created "2018-06-13" @default.
• W2805662486 creator A5012638627 @default.
• W2805662486 creator A5013184354 @default.
• W2805662486 creator A5015690005 @default.
• W2805662486 creator A5025362571 @default.
• W2805662486 creator A5029956662 @default.
• W2805662486 creator A5031321430 @default.
• W2805662486 creator A5037581006 @default.
• W2805662486 creator A5061002857 @default.
• W2805662486 date "2018-06-06" @default.
• W2805662486 modified "2023-10-14" @default.
• W2805662486 title "Education and myopia: assessing the direction of causality by mendelian randomisation" @default.
• W2805662486 cites W1460786101 @default.
• W2805662486 cites W1537717727 @default.
• W2805662486 cites W1858727163 @default.
• W2805662486 cites W1886115468 @default.
• W2805662486 cites W1910278600 @default.
• W2805662486 cites W1964657188 @default.
• W2805662486 cites W1964838260 @default.
• W2805662486 cites W1974004836 @default.
• W2805662486 cites W1975128894 @default.
• W2805662486 cites W1976485261 @default.
• W2805662486 cites W198015242 @default.
• W2805662486 cites W1980863004 @default.
• W2805662486 cites W1988577995 @default.
• W2805662486 cites W1989595223 @default.
• W2805662486 cites W1993586655 @default.
• W2805662486 cites W2001256485 @default.
• W2805662486 cites W2011666342 @default.
• W2805662486 cites W2022888973 @default.
• W2805662486 cites W2031307250 @default.
• W2805662486 cites W2041946781 @default.
• W2805662486 cites W2049190580 @default.
• W2805662486 cites W2052518513 @default.
• W2805662486 cites W2057760857 @default.
• W2805662486 cites W2058685320 @default.
• W2805662486 cites W2063746744 @default.
• W2805662486 cites W2065651845 @default.
• W2805662486 cites W2067095492 @default.
• W2805662486 cites W2073394882 @default.
• W2805662486 cites W2074727025 @default.
• W2805662486 cites W2077546401 @default.
• W2805662486 cites W2082704080 @default.
• W2805662486 cites W2084586811 @default.
• W2805662486 cites W2091317699 @default.
• W2805662486 cites W2096940418 @default.
• W2805662486 cites W2098278949 @default.
• W2805662486 cites W2103783427 @default.
• W2805662486 cites W2106036991 @default.
• W2805662486 cites W2108443239 @default.
• W2805662486 cites W2113699335 @default.
• W2805662486 cites W2115703211 @default.
• W2805662486 cites W2118008714 @default.
• W2805662486 cites W2118034309 @default.
• W2805662486 cites W2118743532 @default.
• W2805662486 cites W2123131638 @default.
• W2805662486 cites W2130339812 @default.
• W2805662486 cites W2135939475 @default.
• W2805662486 cites W2136376873 @default.
• W2805662486 cites W2137264803 @default.
• W2805662486 cites W2139340376 @default.
• W2805662486 cites W2139970805 @default.
• W2805662486 cites W2141257486 @default.
• W2805662486 cites W2149705075 @default.
• W2805662486 cites W2153117775 @default.
• W2805662486 cites W2164363851 @default.
• W2805662486 cites W2165576114 @default.
• W2805662486 cites W2167376427 @default.
• W2805662486 cites W2170630923 @default.
• W2805662486 cites W2263495255 @default.
• W2805662486 cites W2325761966 @default.
• W2805662486 cites W2337943012 @default.
• W2805662486 cites W2346626662 @default.
• W2805662486 cites W2401811918 @default.
• W2805662486 cites W2420070117 @default.
• W2805662486 cites W2517691027 @default.
• W2805662486 cites W2559774263 @default.
• W2805662486 cites W2604373801 @default.
• W2805662486 cites W2723723801 @default.
• W2805662486 cites W2740836480 @default.
• W2805662486 cites W2760551522 @default.
• W2805662486 cites W2771685185 @default.
• W2805662486 cites W2791251830 @default.
• W2805662486 cites W2917476364 @default.
• W2805662486 cites W3124162861 @default.
• W2805662486 cites W49296703 @default.
• W2805662486 cites W7183366 @default.
• W2805662486 doi "https://doi.org/10.1136/bmj.k2022" @default.
• W2805662486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5987847" @default.
• W2805662486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29875094" @default.
• W2805662486 hasPublicationYear "2018" @default.
• W2805662486 type Work @default.
• W2805662486 sameAs 2805662486 @default.
• W2805662486 citedByCount "162" @default.
• W2805662486 countsByYear W28056624862018 @default.
• W2805662486 countsByYear W28056624862019 @default.
• W2805662486 countsByYear W28056624862020 @default.

• next