FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805666090> ?p ?o ?g. }

• W2805666090 abstract "Mast cells integrate innate and adaptive immunity and are implicated in pathophysiological conditions, including allergy, asthma, and anaphylaxis. Cross-linking of the high-affinity IgE receptor (FcεRI) initiates diverse signal transduction pathways and induces release of proinflammatory mediators by mast cells. In this study, we demonstrated that hyperactivation of mechanistic target of rapamycin (mTOR) signaling using the mTOR activator MHY1485 suppresses FcεRI-mediated mast cell degranulation and cytokine secretion. MHY1485 treatment increased ribosomal protein S6 kinase (S6K) and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphorylation, which are downstream targets of mTOR complex 1 (mTORC1), but decreased phosphorylation of Akt on mTOR complex 2 (mTORC2) target site serine 473. In addition, this activator decreased β-hexosaminidase, IL-6, and tumor necrosis factor α (TNF-α) release in murine bone marrow-derived mast cells (BMMCs) after FcεRI stimulation. Furthermore, MHY1485-treated BMMCs showed significantly decreased proliferation when cultured with IL-3. These findings suggested hyperactivation of mTORC1 as a therapeutic strategy for mast cell-related diseases." @default.
• W2805666090 created "2018-06-13" @default.
• W2805666090 creator A5029794176 @default.
• W2805666090 creator A5060164579 @default.
• W2805666090 creator A5060804217 @default.
• W2805666090 date "2018-01-01" @default.
• W2805666090 modified "2023-10-16" @default.
• W2805666090 title "Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485" @default.
• W2805666090 cites W1533374366 @default.
• W2805666090 cites W1564391065 @default.
• W2805666090 cites W1942487602 @default.
• W2805666090 cites W1950481374 @default.
• W2805666090 cites W1970877848 @default.
• W2805666090 cites W1979278210 @default.
• W2805666090 cites W1982386486 @default.
• W2805666090 cites W1985820389 @default.
• W2805666090 cites W1990199004 @default.
• W2805666090 cites W1990524611 @default.
• W2805666090 cites W1991928393 @default.
• W2805666090 cites W1997465096 @default.
• W2805666090 cites W2034700616 @default.
• W2805666090 cites W2036611467 @default.
• W2805666090 cites W2038355016 @default.
• W2805666090 cites W2056137479 @default.
• W2805666090 cites W2092026046 @default.
• W2805666090 cites W2098259959 @default.
• W2805666090 cites W2127063807 @default.
• W2805666090 cites W2150595264 @default.
• W2805666090 cites W2152589884 @default.
• W2805666090 cites W2160307820 @default.
• W2805666090 cites W2210729715 @default.
• W2805666090 cites W2556132920 @default.
• W2805666090 cites W2565374367 @default.
• W2805666090 cites W2616112277 @default.
• W2805666090 cites W2767266192 @default.
• W2805666090 cites W4229688459 @default.
• W2805666090 doi "https://doi.org/10.4110/in.2018.18.e18" @default.
• W2805666090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6026687" @default.
• W2805666090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29984036" @default.
• W2805666090 hasPublicationYear "2018" @default.
• W2805666090 type Work @default.
• W2805666090 sameAs 2805666090 @default.
• W2805666090 citedByCount "18" @default.
• W2805666090 countsByYear W28056660902019 @default.
• W2805666090 countsByYear W28056660902020 @default.
• W2805666090 countsByYear W28056660902021 @default.
• W2805666090 countsByYear W28056660902022 @default.
• W2805666090 countsByYear W28056660902023 @default.
• W2805666090 crossrefType "journal-article" @default.
• W2805666090 hasAuthorship W2805666090A5029794176 @default.
• W2805666090 hasAuthorship W2805666090A5060164579 @default.
• W2805666090 hasAuthorship W2805666090A5060804217 @default.
• W2805666090 hasBestOaLocation W28056660902 @default.
• W2805666090 hasConcept C104202773 @default.
• W2805666090 hasConcept C107846503 @default.
• W2805666090 hasConcept C11960822 @default.
• W2805666090 hasConcept C164027704 @default.
• W2805666090 hasConcept C170493617 @default.
• W2805666090 hasConcept C17991360 @default.
• W2805666090 hasConcept C203014093 @default.
• W2805666090 hasConcept C2776914184 @default.
• W2805666090 hasConcept C2777949483 @default.
• W2805666090 hasConcept C2778690821 @default.
• W2805666090 hasConcept C2779726688 @default.
• W2805666090 hasConcept C49802076 @default.
• W2805666090 hasConcept C502942594 @default.
• W2805666090 hasConcept C55493867 @default.
• W2805666090 hasConcept C62478195 @default.
• W2805666090 hasConcept C75217442 @default.
• W2805666090 hasConcept C86554907 @default.
• W2805666090 hasConcept C86803240 @default.
• W2805666090 hasConcept C88045685 @default.
• W2805666090 hasConcept C95444343 @default.
• W2805666090 hasConcept C98490376 @default.
• W2805666090 hasConceptScore W2805666090C104202773 @default.
• W2805666090 hasConceptScore W2805666090C107846503 @default.
• W2805666090 hasConceptScore W2805666090C11960822 @default.
• W2805666090 hasConceptScore W2805666090C164027704 @default.
• W2805666090 hasConceptScore W2805666090C170493617 @default.
• W2805666090 hasConceptScore W2805666090C17991360 @default.
• W2805666090 hasConceptScore W2805666090C203014093 @default.
• W2805666090 hasConceptScore W2805666090C2776914184 @default.
• W2805666090 hasConceptScore W2805666090C2777949483 @default.
• W2805666090 hasConceptScore W2805666090C2778690821 @default.
• W2805666090 hasConceptScore W2805666090C2779726688 @default.
• W2805666090 hasConceptScore W2805666090C49802076 @default.
• W2805666090 hasConceptScore W2805666090C502942594 @default.
• W2805666090 hasConceptScore W2805666090C55493867 @default.
• W2805666090 hasConceptScore W2805666090C62478195 @default.
• W2805666090 hasConceptScore W2805666090C75217442 @default.
• W2805666090 hasConceptScore W2805666090C86554907 @default.
• W2805666090 hasConceptScore W2805666090C86803240 @default.
• W2805666090 hasConceptScore W2805666090C88045685 @default.
• W2805666090 hasConceptScore W2805666090C95444343 @default.
• W2805666090 hasConceptScore W2805666090C98490376 @default.
• W2805666090 hasFunder F4320322033 @default.
• W2805666090 hasFunder F4320322120 @default.
• W2805666090 hasIssue "3" @default.
• W2805666090 hasLocation W28056660901 @default.
• W2805666090 hasLocation W28056660902 @default.

• next