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- W2805666988 abstract "Abstract The in situ 3-D organization of chromatin at the nucleosome and oligonucleosome levels is unknown. Here we use cryo-electron tomography (cryo-ET) to determine the in situ structures of HeLa nucleosomes, which have canonical core structures and asymmetric, flexible linker DNA. Subtomogram remapping suggests that sequential nucleosomes in heterochromatin follow irregular paths at the oligonucleosome level. This basic principle of higher-order repressive chromatin folding is compatible with the conformational variability of the two linker DNAs at the single-nucleosome level." @default.
- W2805666988 created "2018-06-13" @default.
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- W2805666988 date "2018-05-30" @default.
- W2805666988 modified "2023-10-17" @default.
- W2805666988 title "The in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin" @default.
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- W2805666988 doi "https://doi.org/10.1101/334490" @default.
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