Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805692491> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2805692491 endingPage "863" @default.
- W2805692491 startingPage "857" @default.
- W2805692491 abstract "Abstract Background Daratumumab, a monoclonal antibody used to treat relapsed or refractory multiple myeloma, can interfere with protein electrophoresis and immunofixation assays. False-positive immunofixation results due to daratumumab can cause uncertainty regarding the status of a patient's disease and lead to potential misclassification of their response to therapy. The Hydrashift 2/4 Daratumumab assay (Sebia) was recently cleared by the Food and Drug Administration for resolving daratumumab interference on immunofixation. Here, we evaluate the performance of the Hydrashift assay in multiple myeloma patients receiving treatment with daratumumab-based regimens. Methods Waste serum samples from multiple myeloma patients (n = 40) receiving daratumumab were analyzed by standard immunofixation and the Hydrashift assay. Results from these tests were compared and were evaluated along with pretreatment serum protein electrophoresis and immunofixation results, if available. Results The Hydrashift assay shifted the migration of daratumumab in patient samples. In 27 cases, the patient's M protein was distinguishable from daratumumab by standard immunofixation. In these cases, the Hydrashift assay confirmed that the IgGκ band was daratumumab and helped identify the presence of treatment-related oligoclonal bands. There were 11 instances in which the patient's IgGκ M protein comigrated with daratumumab. In all 11 cases, the Hydrashift assay confirmed the presence of residual M protein. Finally, in 2 patients whose pretreatment immunofixation results were not available, the Hydrashift assay confirmed that the IgGκ band visible on immunofixation was due to daratumumab alone. Conclusions The Hydrashift 2/4 Daratumumab assay is a useful tool to clarify the source of an IgGκ band on immunofixation and allow a patient's M protein to be viewed without interference." @default.
- W2805692491 created "2018-06-13" @default.
- W2805692491 creator A5011669959 @default.
- W2805692491 creator A5028884212 @default.
- W2805692491 creator A5046660414 @default.
- W2805692491 creator A5054205236 @default.
- W2805692491 creator A5074049305 @default.
- W2805692491 date "2019-03-01" @default.
- W2805692491 modified "2023-10-18" @default.
- W2805692491 title "Distinguishing Drug from Disease by Use of the Hydrashift 2/4 Daratumumab Assay" @default.
- W2805692491 cites W2125210373 @default.
- W2805692491 cites W2252820304 @default.
- W2805692491 cites W2325601336 @default.
- W2805692491 cites W2347029194 @default.
- W2805692491 cites W2486629951 @default.
- W2805692491 cites W2511375217 @default.
- W2805692491 cites W2521935338 @default.
- W2805692491 cites W2588087999 @default.
- W2805692491 cites W2617175901 @default.
- W2805692491 cites W2748238482 @default.
- W2805692491 cites W2760963340 @default.
- W2805692491 cites W2772566228 @default.
- W2805692491 doi "https://doi.org/10.1373/jalm.2018.026476" @default.
- W2805692491 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7484995" @default.
- W2805692491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31639760" @default.
- W2805692491 hasPublicationYear "2019" @default.
- W2805692491 type Work @default.
- W2805692491 sameAs 2805692491 @default.
- W2805692491 citedByCount "22" @default.
- W2805692491 countsByYear W28056924912019 @default.
- W2805692491 countsByYear W28056924912020 @default.
- W2805692491 countsByYear W28056924912021 @default.
- W2805692491 countsByYear W28056924912022 @default.
- W2805692491 countsByYear W28056924912023 @default.
- W2805692491 crossrefType "journal-article" @default.
- W2805692491 hasAuthorship W2805692491A5011669959 @default.
- W2805692491 hasAuthorship W2805692491A5028884212 @default.
- W2805692491 hasAuthorship W2805692491A5046660414 @default.
- W2805692491 hasAuthorship W2805692491A5054205236 @default.
- W2805692491 hasAuthorship W2805692491A5074049305 @default.
- W2805692491 hasBestOaLocation W28056924911 @default.
- W2805692491 hasConcept C126322002 @default.
- W2805692491 hasConcept C143998085 @default.
- W2805692491 hasConcept C159654299 @default.
- W2805692491 hasConcept C163864487 @default.
- W2805692491 hasConcept C203014093 @default.
- W2805692491 hasConcept C2776364478 @default.
- W2805692491 hasConcept C2776855637 @default.
- W2805692491 hasConcept C2777478702 @default.
- W2805692491 hasConcept C2778808339 @default.
- W2805692491 hasConcept C2781119759 @default.
- W2805692491 hasConcept C542903549 @default.
- W2805692491 hasConcept C71924100 @default.
- W2805692491 hasConceptScore W2805692491C126322002 @default.
- W2805692491 hasConceptScore W2805692491C143998085 @default.
- W2805692491 hasConceptScore W2805692491C159654299 @default.
- W2805692491 hasConceptScore W2805692491C163864487 @default.
- W2805692491 hasConceptScore W2805692491C203014093 @default.
- W2805692491 hasConceptScore W2805692491C2776364478 @default.
- W2805692491 hasConceptScore W2805692491C2776855637 @default.
- W2805692491 hasConceptScore W2805692491C2777478702 @default.
- W2805692491 hasConceptScore W2805692491C2778808339 @default.
- W2805692491 hasConceptScore W2805692491C2781119759 @default.
- W2805692491 hasConceptScore W2805692491C542903549 @default.
- W2805692491 hasConceptScore W2805692491C71924100 @default.
- W2805692491 hasFunder F4320332161 @default.
- W2805692491 hasFunder F4320337472 @default.
- W2805692491 hasIssue "5" @default.
- W2805692491 hasLocation W28056924911 @default.
- W2805692491 hasLocation W28056924912 @default.
- W2805692491 hasOpenAccess W2805692491 @default.
- W2805692491 hasPrimaryLocation W28056924911 @default.
- W2805692491 hasRelatedWork W2053927081 @default.
- W2805692491 hasRelatedWork W2060630093 @default.
- W2805692491 hasRelatedWork W2521935338 @default.
- W2805692491 hasRelatedWork W2612749273 @default.
- W2805692491 hasRelatedWork W2783261044 @default.
- W2805692491 hasRelatedWork W2807762966 @default.
- W2805692491 hasRelatedWork W2944799419 @default.
- W2805692491 hasRelatedWork W3135402041 @default.
- W2805692491 hasRelatedWork W3212419087 @default.
- W2805692491 hasRelatedWork W4281651215 @default.
- W2805692491 hasVolume "3" @default.
- W2805692491 isParatext "false" @default.
- W2805692491 isRetracted "false" @default.
- W2805692491 magId "2805692491" @default.
- W2805692491 workType "article" @default.