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• W2805698568 abstract "Muscle injuries often lead to structural and functional deficits and recurrent injuries. Nitric oxide (NO) is an endogenous bioactive molecule with multiple physiological roles. Pharmacological NO inhibition negatively effects regeneration, with excessive fibrosis, suggesting that treatment with NO may prove to be beneficial. PURPOSE: To assess a) anti-fibrotic and pro-regenerative roles of NO following muscle trauma and b) muscle function recovery following injury by treating with either NO donor or inhibitor. METHODS: The gastrocnemius of adult male rats were contusion injured (250g drop-mass) followed by one of four treatments (placebo, NO-donor, NO-inhibitor or combination) administered immediately and one day post-injury and in un-injured controls. Rats were sacrificed at 5 (D5) and 21 (D21) days after intervention (n=6/group; total n=78). In situ mechanics testing was done pre-injury and before sacrifice to determine plantar flexor contractility. Fibrosis staining was done using Masson’s trichrome and Sirius red. Embryonic MHC (eMHC) was used to identify new and regenerating muscle fibers, including cross-sectional area (CSA). RESULTS: Maximal isometric force was significantly reduced D5 post-injury (19.5 ±3.1 N/kg) compared to pre-injury (26.0 ±2.5 N/kg; p < 0.0001). D21 maximal force was significantly higher in the NO-donor group (27.2 ±3.3 N/kg) versus L-NAME (21.7 ±3.7 N/kg; p < 0.05) and combination (21.6 ±3.8 N/kg; p < 0.05). NO-donor significantly increased eMHC protein expression (5.29 ±2.64 AU versus Plac: 0.65 ±0.64; L-NAME: 0.58 ±0.51; Comb: 0.45 ±0.9 AU; p < 0.001) and new fiber CSA (501 ±34 um2) versus other treatments (Plac: 421 ±27 p< 0.01; L-NAME: 240 ±38 p<0.001; Comb: 313 ±36 um2; p<0.001). Picrosirius red staining indicated that NO-donor treatment reduced fibrosis (7.33 ±1.87 %; Plac: 18.28 ±3.94; p< 0.0001). Masson’s trichrome staining indicated a significant increase in fibrosis following NO inhibition (22.88 ±1.57 %; p<0.01). CONCLUSION: Maximal force production recovered fully 21 days after injury in placebo-treated rats. NO influenced recovery of physiological function resulting in further increased maximal force production at D21, compared to a reduction following L-NAME treatment. This may be due to improvement in regenerative myogenesis and reduction in fibrosis." @default.
• W2805698568 created "2018-06-13" @default.
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• W2805698568 date "2018-05-01" @default.
• W2805698568 modified "2023-09-27" @default.
• W2805698568 title "The Effect Of Nitric Oxide Donor Treatment On Skeletal Muscle Repair Following Contusion Injury In Rats" @default.
• W2805698568 doi "https://doi.org/10.1249/01.mss.0000538237.32272.19" @default.
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