FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805746361> ?p ?o ?g. }

• W2805746361 abstract "Coronary artery disease (CAD) is the leading cause of mortality worldwide and poses a considerable public health burden. Recent genome-wide association studies (GWAS) have revealed >100 genetic loci associated with CAD susceptibility in humans. While a number of these loci harbor gene targets of currently approved therapies, such as statins and PCSK9 inhibitors, the majority of the annotated genes at these loci encode for proteins involved in vessel wall function with no known drugs available. Importantly many of the associated genes linked to vascular (smooth muscle, endothelial, and macrophage) cell processes are now organized into distinct functional pathways, e.g. vasodilation, growth factor responses, extracellular matrix and plaque remodeling, and inflammation. In this mini-review, we highlight the most recently identified loci that have predicted roles in the vessel wall and provide genetic context for pre-existing therapies as well as new drug targets informed from GWAS. With the development of new modalities to target these pathways, (e.g. antisense oligonucleotides, CRISPR/Cas9, and RNA interference) as well as the computational frameworks to prioritize or reposition therapeutics, there is great opportunity to close the gap from initial genetic discovery to clinical translation for many patients affected by this common disease." @default.
• W2805746361 created "2018-06-13" @default.
• W2805746361 creator A5003077515 @default.
• W2805746361 creator A5033415531 @default.
• W2805746361 creator A5037150521 @default.
• W2805746361 creator A5074707842 @default.
• W2805746361 date "2018-06-25" @default.
• W2805746361 modified "2023-10-02" @default.
• W2805746361 title "GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease" @default.
• W2805746361 cites W1499959019 @default.
• W2805746361 cites W1787824584 @default.
• W2805746361 cites W1860793010 @default.
• W2805746361 cites W1904549514 @default.
• W2805746361 cites W1968893448 @default.
• W2805746361 cites W1975914633 @default.
• W2805746361 cites W1978546929 @default.
• W2805746361 cites W2004422966 @default.
• W2805746361 cites W2005102765 @default.
• W2805746361 cites W2009609922 @default.
• W2805746361 cites W2012684922 @default.
• W2805746361 cites W2036198235 @default.
• W2805746361 cites W2037959887 @default.
• W2805746361 cites W2040612932 @default.
• W2805746361 cites W2040916923 @default.
• W2805746361 cites W2046404715 @default.
• W2805746361 cites W2046801160 @default.
• W2805746361 cites W2048755332 @default.
• W2805746361 cites W2052244730 @default.
• W2805746361 cites W2054785760 @default.
• W2805746361 cites W2068896961 @default.
• W2805746361 cites W2071759640 @default.
• W2805746361 cites W2079533180 @default.
• W2805746361 cites W2095821741 @default.
• W2805746361 cites W2097572487 @default.
• W2805746361 cites W2100114559 @default.
• W2805746361 cites W2101605059 @default.
• W2805746361 cites W2104177528 @default.
• W2805746361 cites W2107707255 @default.
• W2805746361 cites W2112848098 @default.
• W2805746361 cites W2115801316 @default.
• W2805746361 cites W2117786309 @default.
• W2805746361 cites W2120451046 @default.
• W2805746361 cites W2122035554 @default.
• W2805746361 cites W2125895642 @default.
• W2805746361 cites W2127647970 @default.
• W2805746361 cites W2129079051 @default.
• W2805746361 cites W2131026852 @default.
• W2805746361 cites W2135147724 @default.
• W2805746361 cites W2136925980 @default.
• W2805746361 cites W2139957955 @default.
• W2805746361 cites W2140079333 @default.
• W2805746361 cites W2143610409 @default.
• W2805746361 cites W2143727405 @default.
• W2805746361 cites W2153118028 @default.
• W2805746361 cites W2161527180 @default.
• W2805746361 cites W2166124982 @default.
• W2805746361 cites W2169413839 @default.
• W2805746361 cites W2169555151 @default.
• W2805746361 cites W2219320351 @default.
• W2805746361 cites W2238851414 @default.
• W2805746361 cites W2274924551 @default.
• W2805746361 cites W2281768098 @default.
• W2805746361 cites W2292979619 @default.
• W2805746361 cites W2294302252 @default.
• W2805746361 cites W2315899065 @default.
• W2805746361 cites W2343313313 @default.
• W2805746361 cites W2344228184 @default.
• W2805746361 cites W2467359821 @default.
• W2805746361 cites W2473055487 @default.
• W2805746361 cites W2479301202 @default.
• W2805746361 cites W2485327755 @default.
• W2805746361 cites W2521147375 @default.
• W2805746361 cites W2581452190 @default.
• W2805746361 cites W2585441851 @default.
• W2805746361 cites W2587804655 @default.
• W2805746361 cites W2587939208 @default.
• W2805746361 cites W2593219710 @default.
• W2805746361 cites W2612305061 @default.
• W2805746361 cites W2619135473 @default.
• W2805746361 cites W2619767973 @default.
• W2805746361 cites W2621005943 @default.
• W2805746361 cites W2626878522 @default.
• W2805746361 cites W2735404270 @default.
• W2805746361 cites W2737154013 @default.
• W2805746361 cites W2741551607 @default.
• W2805746361 cites W2748400555 @default.
• W2805746361 cites W2775393828 @default.
• W2805746361 cites W2781493051 @default.
• W2805746361 cites W4301792097 @default.
• W2805746361 cites W597219917 @default.
• W2805746361 doi "https://doi.org/10.3389/fcvm.2018.00072" @default.
• W2805746361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6026658" @default.
• W2805746361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29988570" @default.
• W2805746361 hasPublicationYear "2018" @default.
• W2805746361 type Work @default.
• W2805746361 sameAs 2805746361 @default.
• W2805746361 citedByCount "15" @default.
• W2805746361 countsByYear W28057463612019 @default.
• W2805746361 countsByYear W28057463612020 @default.
• W2805746361 countsByYear W28057463612021 @default.

• next