FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805757612> ?p ?o ?g. }

• W2805757612 abstract "The knee joint is a complex weight bearing joint that has a high incidence of degenerative change and knee OA. Consequently, there is a need to develop a greater understanding of factors that may affect knee articular cartilage and influence long term health of the knee joint. The overall aim of this thesis was to specifically investigate the effect of ageing and physical activity on several serum biomarkers that have been found to have a different profile among individuals with degenerative knee conditions such as OA. These biomarkers included: serum COMP, which is understood to be a marker of cartilage degeneration or metabolism; serum HA, which is also understood to be both a marker of cartilage degeneration and synovial inflammation; serum lubricin, which is understood to be a marker of joint lubrication; and finally, femoral cartilage thickness assessed by ultrasound (US), which provides a morphological measurement of the articular cartilage. Firstly, in Chapter 4, the feasibility of measuring femoral cartilage thickness using US was determined. This study demonstrated high intra-tester reliability, measurement precision, and revealed that femoral cartilage thickness has a large variability in healthy individuals across a range of ages. In a subsequent cross-sectional study (Chapter 5), results indicated that ageing does not inevitably result in degenerative change of articular cartilage in healthy males. Moreover, physical activity was not associated with any adverse changes to joint markers, and instead, was associated with greater lateral condyle cartilage thickness in this cohort. Chapters 6 and 7 specifically explored acute joint loading. Acute exercise increased serum lubricin and COMP with no change in serum HA. The increase in serum COMP and lubricin suggests an increase in cartilage metabolism and joint lubrication, respectively. However, somewhat surprisingly this response did not differ between weight bearing and non-weight bearing exercise. The follow up study compared aerobic exercise with resistance training. Despite substantial differences in the loading magnitude and frequency between lower body resistance exercise and walking exercise, both exercise modalities resulted in a similar response in serum biomarkers. There was also no difference between the exercise response in both healthy male and female individuals. Overall, this research has provided new evidence to suggest that both healthy ageing and physical activity are not associated with adverse changes to the articular cartilage. Moreover, while acute exercise typically results in a significant increase in both serum COMP and lubricin, neither exercise modality nor gender appears to alter the response to acute loading." @default.
• W2805757612 created "2018-06-13" @default.
• W2805757612 creator A5014359527 @default.
• W2805757612 date "2017-01-01" @default.
• W2805757612 modified "2023-09-23" @default.
• W2805757612 title "The effect of exercise and ageing on morphology and biomarkers of knee articular cartilage in healthy humans" @default.
• W2805757612 cites W1485381082 @default.
• W2805757612 cites W1506251539 @default.
• W2805757612 cites W1532082365 @default.
• W2805757612 cites W1549922475 @default.
• W2805757612 cites W1551473534 @default.
• W2805757612 cites W1572936745 @default.
• W2805757612 cites W1747242061 @default.
• W2805757612 cites W1752390518 @default.
• W2805757612 cites W1779464222 @default.
• W2805757612 cites W1809795898 @default.
• W2805757612 cites W1821739051 @default.
• W2805757612 cites W1883440939 @default.
• W2805757612 cites W1903221556 @default.
• W2805757612 cites W1908122637 @default.
• W2805757612 cites W1963782120 @default.
• W2805757612 cites W1965356667 @default.
• W2805757612 cites W1966464696 @default.
• W2805757612 cites W1971488123 @default.
• W2805757612 cites W1972306906 @default.
• W2805757612 cites W1973095362 @default.
• W2805757612 cites W1974511102 @default.
• W2805757612 cites W1974640471 @default.
• W2805757612 cites W1974944864 @default.
• W2805757612 cites W1977040840 @default.
• W2805757612 cites W1977500066 @default.
• W2805757612 cites W1977592675 @default.
• W2805757612 cites W1978282772 @default.
• W2805757612 cites W1981434280 @default.
• W2805757612 cites W1982171868 @default.
• W2805757612 cites W1982799550 @default.
• W2805757612 cites W1983774206 @default.
• W2805757612 cites W1985605914 @default.
• W2805757612 cites W1985935486 @default.
• W2805757612 cites W1988050136 @default.
• W2805757612 cites W1988147011 @default.
• W2805757612 cites W1988843503 @default.
• W2805757612 cites W1989462291 @default.
• W2805757612 cites W1989856361 @default.
• W2805757612 cites W1991729257 @default.
• W2805757612 cites W1992550277 @default.
• W2805757612 cites W1993134903 @default.
• W2805757612 cites W1993969318 @default.
• W2805757612 cites W1995120265 @default.
• W2805757612 cites W1995577167 @default.
• W2805757612 cites W199669449 @default.
• W2805757612 cites W1996773341 @default.
• W2805757612 cites W1999658463 @default.
• W2805757612 cites W2000318892 @default.
• W2805757612 cites W2000566071 @default.
• W2805757612 cites W2000660668 @default.
• W2805757612 cites W2001646063 @default.
• W2805757612 cites W2001762931 @default.
• W2805757612 cites W2003107253 @default.
• W2805757612 cites W2003695513 @default.
• W2805757612 cites W2004008756 @default.
• W2805757612 cites W2004112191 @default.
• W2805757612 cites W2005556241 @default.
• W2805757612 cites W2005739307 @default.
• W2805757612 cites W2006854627 @default.
• W2805757612 cites W2006962749 @default.
• W2805757612 cites W2008417685 @default.
• W2805757612 cites W2010294534 @default.
• W2805757612 cites W2010972331 @default.
• W2805757612 cites W2011038175 @default.
• W2805757612 cites W2011472347 @default.
• W2805757612 cites W2013570510 @default.
• W2805757612 cites W2014333898 @default.
• W2805757612 cites W2015423555 @default.
• W2805757612 cites W2018125997 @default.
• W2805757612 cites W2019401802 @default.
• W2805757612 cites W2019647106 @default.
• W2805757612 cites W2020126553 @default.
• W2805757612 cites W2020299595 @default.
• W2805757612 cites W2021665203 @default.
• W2805757612 cites W2022665899 @default.
• W2805757612 cites W2022716558 @default.
• W2805757612 cites W2023917616 @default.
• W2805757612 cites W2025086334 @default.
• W2805757612 cites W2027168723 @default.
• W2805757612 cites W2027831505 @default.
• W2805757612 cites W2027894791 @default.
• W2805757612 cites W2027904175 @default.
• W2805757612 cites W2028985265 @default.
• W2805757612 cites W2029393328 @default.
• W2805757612 cites W2029597318 @default.
• W2805757612 cites W2030138474 @default.
• W2805757612 cites W2030483855 @default.
• W2805757612 cites W2031247908 @default.
• W2805757612 cites W2031416591 @default.
• W2805757612 cites W2033015989 @default.
• W2805757612 cites W2033133946 @default.
• W2805757612 cites W2033379925 @default.
• W2805757612 cites W2034147588 @default.
• W2805757612 cites W2038536739 @default.

• next