Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805815575> ?p ?o ?g. }
- W2805815575 endingPage "960.e4" @default.
- W2805815575 startingPage "949" @default.
- W2805815575 abstract "The mammalian Target of Rapamycin Complex 1 (mTORC1)-signaling system plays a critical role in the maintenance of cellular homeostasis by sensing and integrating multiple extracellular and intracellular cues. Therefore, uncovering the effectors of mTORC1 signaling is pivotal to understanding its pathophysiological effects. Here we report that the transcription factor forkhead/winged helix family k1 (Foxk1) is a mediator of mTORC1-regulated gene expression. Surprisingly, Foxk1 phosphorylation is increased upon mTORC1 suppression, which elicits a 14-3-3 interaction, a reduction of DNA binding, and nuclear exclusion. Mechanistically, this occurs by mTORC1-dependent suppression of nuclear signaling by the Foxk1 kinase, Gsk3. This pathway then regulates the expression of multiple genes associated with glycolysis and downstream anabolic pathways directly modulated by Foxk1 and/or by Foxk1-regulated expression of Hif-1α. Thus, Foxk1 mediates mTORC1-driven metabolic rewiring, and it is likely to be critical for metabolic diseases where improper mTORC1 signaling plays an important role." @default.
- W2805815575 created "2018-06-13" @default.
- W2805815575 creator A5009362044 @default.
- W2805815575 creator A5013174841 @default.
- W2805815575 creator A5013507111 @default.
- W2805815575 creator A5019076582 @default.
- W2805815575 creator A5019512477 @default.
- W2805815575 creator A5025051152 @default.
- W2805815575 creator A5031737778 @default.
- W2805815575 creator A5041241925 @default.
- W2805815575 creator A5057084504 @default.
- W2805815575 creator A5060962435 @default.
- W2805815575 creator A5083115947 @default.
- W2805815575 creator A5084966811 @default.
- W2805815575 creator A5087327220 @default.
- W2805815575 date "2018-06-01" @default.
- W2805815575 modified "2023-10-18" @default.
- W2805815575 title "mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation" @default.
- W2805815575 cites W1523693806 @default.
- W2805815575 cites W1982219839 @default.
- W2805815575 cites W1996260337 @default.
- W2805815575 cites W1998664010 @default.
- W2805815575 cites W2001775267 @default.
- W2805815575 cites W2008102952 @default.
- W2805815575 cites W2047791731 @default.
- W2805815575 cites W2053874502 @default.
- W2805815575 cites W2067874044 @default.
- W2805815575 cites W2075997152 @default.
- W2805815575 cites W2082483448 @default.
- W2805815575 cites W2094069034 @default.
- W2805815575 cites W2094399892 @default.
- W2805815575 cites W2095820546 @default.
- W2805815575 cites W2098628437 @default.
- W2805815575 cites W2102904139 @default.
- W2805815575 cites W2105016405 @default.
- W2805815575 cites W2111352469 @default.
- W2805815575 cites W2122772601 @default.
- W2805815575 cites W2138871725 @default.
- W2805815575 cites W2145804860 @default.
- W2805815575 cites W2153607816 @default.
- W2805815575 cites W2157952888 @default.
- W2805815575 cites W2162404348 @default.
- W2805815575 cites W2383259826 @default.
- W2805815575 cites W2521282167 @default.
- W2805815575 cites W2580449060 @default.
- W2805815575 cites W2593816418 @default.
- W2805815575 cites W2605743056 @default.
- W2805815575 cites W2606513998 @default.
- W2805815575 cites W2770290595 @default.
- W2805815575 cites W2896869836 @default.
- W2805815575 cites W4237534021 @default.
- W2805815575 doi "https://doi.org/10.1016/j.molcel.2018.04.024" @default.
- W2805815575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6591025" @default.
- W2805815575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29861159" @default.
- W2805815575 hasPublicationYear "2018" @default.
- W2805815575 type Work @default.
- W2805815575 sameAs 2805815575 @default.
- W2805815575 citedByCount "95" @default.
- W2805815575 countsByYear W28058155752018 @default.
- W2805815575 countsByYear W28058155752019 @default.
- W2805815575 countsByYear W28058155752020 @default.
- W2805815575 countsByYear W28058155752021 @default.
- W2805815575 countsByYear W28058155752022 @default.
- W2805815575 countsByYear W28058155752023 @default.
- W2805815575 crossrefType "journal-article" @default.
- W2805815575 hasAuthorship W2805815575A5009362044 @default.
- W2805815575 hasAuthorship W2805815575A5013174841 @default.
- W2805815575 hasAuthorship W2805815575A5013507111 @default.
- W2805815575 hasAuthorship W2805815575A5019076582 @default.
- W2805815575 hasAuthorship W2805815575A5019512477 @default.
- W2805815575 hasAuthorship W2805815575A5025051152 @default.
- W2805815575 hasAuthorship W2805815575A5031737778 @default.
- W2805815575 hasAuthorship W2805815575A5041241925 @default.
- W2805815575 hasAuthorship W2805815575A5057084504 @default.
- W2805815575 hasAuthorship W2805815575A5060962435 @default.
- W2805815575 hasAuthorship W2805815575A5083115947 @default.
- W2805815575 hasAuthorship W2805815575A5084966811 @default.
- W2805815575 hasAuthorship W2805815575A5087327220 @default.
- W2805815575 hasBestOaLocation W28058155751 @default.
- W2805815575 hasConcept C104317684 @default.
- W2805815575 hasConcept C11960822 @default.
- W2805815575 hasConcept C2107291 @default.
- W2805815575 hasConcept C51785407 @default.
- W2805815575 hasConcept C54355233 @default.
- W2805815575 hasConcept C62478195 @default.
- W2805815575 hasConcept C86339819 @default.
- W2805815575 hasConcept C86554907 @default.
- W2805815575 hasConcept C86803240 @default.
- W2805815575 hasConcept C95444343 @default.
- W2805815575 hasConcept C98490376 @default.
- W2805815575 hasConceptScore W2805815575C104317684 @default.
- W2805815575 hasConceptScore W2805815575C11960822 @default.
- W2805815575 hasConceptScore W2805815575C2107291 @default.
- W2805815575 hasConceptScore W2805815575C51785407 @default.
- W2805815575 hasConceptScore W2805815575C54355233 @default.
- W2805815575 hasConceptScore W2805815575C62478195 @default.
- W2805815575 hasConceptScore W2805815575C86339819 @default.
- W2805815575 hasConceptScore W2805815575C86554907 @default.