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• W2805848981 abstract "Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV. A single monoclonal antibody is therapeutic and has prophylactic activity against Zika virus in monkeys." @default.
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• W2805848981 date "2018-06-01" @default.
• W2805848981 modified "2023-10-17" @default.
• W2805848981 title "Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys" @default.
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• W2805848981 doi "https://doi.org/10.1038/s41591-018-0056-0" @default.
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