FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805853609> ?p ?o ?g. }

• W2805853609 endingPage "348" @default.
• W2805853609 startingPage "339" @default.
• W2805853609 abstract "The antimicrobial glycoprotein neutrophil gelatinase-associated lipocalin (NGAL) is strongly expressed in several infectious, inflammatory and malignant disorders, among these inflammatory bowel disease (IBD). Fecal and serum NGAL is elevated during active IBD and we have recently shown that fecal NGAL is a novel biomarker for IBD with a test performance comparable to the established fecal biomarker calprotectin. This study examines expression of NGAL in the healthy gut and in Crohn's disease (CD), with emphasis on the previously unexplored small intestine. Pinch biopsies were taken from active and inactive CD in jejunum, ileum and colon and from the same sites in healthy controls. Microarray gene expression showed that the NGAL gene, LCN2, was the second most upregulated among 1820 differentially expressed genes in terminal ileum comparing active CD and controls (FC 5.86, p = 0.027). Based on immunohistochemistry and in situ hybridization findings, this upregulation most likely represented increased expression in epithelial cells. Double immunofluorescence showed NGAL expression in 49% (range 19-70) of Paneth cells (PCs) in control ileum with no change during inflammation. In healthy jejunum, the NGAL expression in PCs was weak to none but markedly increased during active CD. We further found NGAL also in metaplastic PCs in colon. Finally, we show for the first time that NGAL is expressed in enteroendocrine cells in small intestine as well as in colon." @default.
• W2805853609 created "2018-06-13" @default.
• W2805853609 creator A5000823104 @default.
• W2805853609 creator A5015585930 @default.
• W2805853609 creator A5023287642 @default.
• W2805853609 creator A5040915656 @default.
• W2805853609 creator A5042675369 @default.
• W2805853609 creator A5069857880 @default.
• W2805853609 creator A5076618953 @default.
• W2805853609 date "2018-06-05" @default.
• W2805853609 modified "2023-09-26" @default.
• W2805853609 title "Expression of neutrophil gelatinase-associated lipocalin (NGAL) in the gut in Crohn’s disease" @default.
• W2805853609 cites W1502623266 @default.
• W2805853609 cites W1554868555 @default.
• W2805853609 cites W1565002994 @default.
• W2805853609 cites W1632718676 @default.
• W2805853609 cites W1965521903 @default.
• W2805853609 cites W1982304490 @default.
• W2805853609 cites W1987836935 @default.
• W2805853609 cites W2014243721 @default.
• W2805853609 cites W2017676790 @default.
• W2805853609 cites W2032782331 @default.
• W2805853609 cites W2036124167 @default.
• W2805853609 cites W2043806528 @default.
• W2805853609 cites W2059466009 @default.
• W2805853609 cites W2074692187 @default.
• W2805853609 cites W2097121808 @default.
• W2805853609 cites W2098587662 @default.
• W2805853609 cites W2102764783 @default.
• W2805853609 cites W2106608030 @default.
• W2805853609 cites W2110931665 @default.
• W2805853609 cites W2113265606 @default.
• W2805853609 cites W2122292170 @default.
• W2805853609 cites W2123416046 @default.
• W2805853609 cites W2133728642 @default.
• W2805853609 cites W2146512944 @default.
• W2805853609 cites W2152863656 @default.
• W2805853609 cites W2156734719 @default.
• W2805853609 cites W2157105773 @default.
• W2805853609 cites W2169392626 @default.
• W2805853609 cites W2173095346 @default.
• W2805853609 cites W2304423786 @default.
• W2805853609 cites W2312090439 @default.
• W2805853609 cites W2461323280 @default.
• W2805853609 cites W2519777062 @default.
• W2805853609 cites W2523075716 @default.
• W2805853609 cites W2583633660 @default.
• W2805853609 cites W2592143606 @default.
• W2805853609 cites W28471655 @default.
• W2805853609 doi "https://doi.org/10.1007/s00441-018-2860-8" @default.
• W2805853609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6209058" @default.
• W2805853609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29869714" @default.
• W2805853609 hasPublicationYear "2018" @default.
• W2805853609 type Work @default.
• W2805853609 sameAs 2805853609 @default.
• W2805853609 citedByCount "25" @default.
• W2805853609 countsByYear W28058536092019 @default.
• W2805853609 countsByYear W28058536092020 @default.
• W2805853609 countsByYear W28058536092021 @default.
• W2805853609 countsByYear W28058536092022 @default.
• W2805853609 countsByYear W28058536092023 @default.
• W2805853609 crossrefType "journal-article" @default.
• W2805853609 hasAuthorship W2805853609A5000823104 @default.
• W2805853609 hasAuthorship W2805853609A5015585930 @default.
• W2805853609 hasAuthorship W2805853609A5023287642 @default.
• W2805853609 hasAuthorship W2805853609A5040915656 @default.
• W2805853609 hasAuthorship W2805853609A5042675369 @default.
• W2805853609 hasAuthorship W2805853609A5069857880 @default.
• W2805853609 hasAuthorship W2805853609A5076618953 @default.
• W2805853609 hasBestOaLocation W28058536091 @default.
• W2805853609 hasConcept C126322002 @default.
• W2805853609 hasConcept C20299238 @default.
• W2805853609 hasConcept C203014093 @default.
• W2805853609 hasConcept C2776366702 @default.
• W2805853609 hasConcept C2777226302 @default.
• W2805853609 hasConcept C2778260677 @default.
• W2805853609 hasConcept C2778292693 @default.
• W2805853609 hasConcept C2779134260 @default.
• W2805853609 hasConcept C2779280984 @default.
• W2805853609 hasConcept C2781197716 @default.
• W2805853609 hasConcept C55493867 @default.
• W2805853609 hasConcept C71924100 @default.
• W2805853609 hasConcept C86803240 @default.
• W2805853609 hasConceptScore W2805853609C126322002 @default.
• W2805853609 hasConceptScore W2805853609C20299238 @default.
• W2805853609 hasConceptScore W2805853609C203014093 @default.
• W2805853609 hasConceptScore W2805853609C2776366702 @default.
• W2805853609 hasConceptScore W2805853609C2777226302 @default.
• W2805853609 hasConceptScore W2805853609C2778260677 @default.
• W2805853609 hasConceptScore W2805853609C2778292693 @default.
• W2805853609 hasConceptScore W2805853609C2779134260 @default.
• W2805853609 hasConceptScore W2805853609C2779280984 @default.
• W2805853609 hasConceptScore W2805853609C2781197716 @default.
• W2805853609 hasConceptScore W2805853609C55493867 @default.
• W2805853609 hasConceptScore W2805853609C71924100 @default.
• W2805853609 hasConceptScore W2805853609C86803240 @default.
• W2805853609 hasIssue "2" @default.
• W2805853609 hasLocation W28058536091 @default.

• next