Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805876407> ?p ?o ?g. }
- W2805876407 abstract "Muscle satellite cells are the primary source of stem cells for postnatal skeletal muscle growth and regeneration. Understanding genetic control of satellite cell formation, maintenance, and acquisition of their stem cell properties is on-going, and we have identified SOXF (SOX7, SOX17, SOX18) transcriptional factors as being induced during satellite cell specification. We demonstrate that SOXF factors regulate satellite cell quiescence, self-renewal and differentiation. Moreover, ablation of Sox17 in the muscle lineage impairs postnatal muscle growth and regeneration. We further determine that activities of SOX7, SOX17 and SOX18 overlap during muscle regeneration, with SOXF transcriptional activity requisite. Finally, we show that SOXF factors also control satellite cell expansion and renewal by directly inhibiting the output of β-catenin activity, including inhibition of Ccnd1 and Axin2. Together, our findings identify a key regulatory function of SoxF genes in muscle stem cells via direct transcriptional control and interaction with canonical Wnt/β-catenin signaling." @default.
- W2805876407 created "2018-06-13" @default.
- W2805876407 creator A5025314263 @default.
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- W2805876407 creator A5059337122 @default.
- W2805876407 creator A5084226352 @default.
- W2805876407 date "2018-06-08" @default.
- W2805876407 modified "2023-10-18" @default.
- W2805876407 title "SOXF factors regulate murine satellite cell self-renewal and function through inhibition of β-catenin activity" @default.
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- W2805876407 doi "https://doi.org/10.7554/elife.26039" @default.
- W2805876407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6021169" @default.
- W2805876407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29882512" @default.
- W2805876407 hasPublicationYear "2018" @default.
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