FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805890484> ?p ?o ?g. }

• W2805890484 abstract "Abstract Background. A group of Russian scientists has developed Diaskintest, which comprises Mycobacterium tuberculosis -specific recombinant proteins CFP10-ESAT6, for skin testing (0.2 µg/0.1 ml). Study purpose: to evaluate the comparative sensitivity of TST with 2 TU PPD-L and a skin test with tuberculous recombinant allergen (Diaskintest) containing the ESAT6-CFP10 protein in children and adolescents with newly diagnosed respiratory tuberculosis during mass screening in the primary medical service in Moscow, 2013–2016. Materials and methods. The trial was a comprehensive retrospective group study of children and adolescents diagnosed in Moscow with respiratory tuberculosis in 2013–2016, aged 0 to 17 years inclusive. From 441 patients selected for analysis 408 patients had both tests (TST with 2 TU PPD-L and Diaskintest) performed, in 193 patients both tests were given simultaneously, of them 162 patients were BCG-vaccinated. Results. Comparative results of both tests in 408 patients with tuberculosis: at cut-off 5 mm, both tests has similar sensitivity: Diaskintest 98.3 % (95 % CI 97.0–99.6 %), TST 98.0 % (95 % CI 96.7–99.4 %), at cut-off 10 mm, the sensitivity decreases for both tests: Diaskintest 90.0 % (95 % CI 87.0–93.0 %), TST 88.7 % (95 % CI 85.6–91.9 %), but at cut-off 15 mm, the decrease in sensitivity is statistically significant: for Diaskintest 61.5 % (95 % CI 56.7–66.3 %), and for TST 46.3 % (95 % CI 41.4–51.3 %), p <0.0001. The results of simultaneous setting of tests on different hands in 193 people (including 162 BCG-vaccinated), do not differ from the results for 408 people. The correlation between the results of Diaskintest and TST was significant in all groups. Conclusion. In children and adolescents with respiratory tuberculosis, Diaskintest of 0.2 µg/ml and the Mantoux test with 2 TU PPD-L have high sensitivity (98%) at a cut-off of 5 mm; however, at cut-off 15 mm sensitivity is significantly reduced, and the decrease is more pronounced in the Mantoux test. The advantage of Diaskintest is that, unlike the Mantoux test, it has high specificity under the conditions of mass BCG vaccination. The test is cost-effective, simple to carry out, and can be used in mass screening." @default.
• W2805890484 created "2018-06-13" @default.
• W2805890484 creator A5017416770 @default.
• W2805890484 creator A5034774633 @default.
• W2805890484 creator A5066044454 @default.
• W2805890484 creator A5077449451 @default.
• W2805890484 date "2018-06-11" @default.
• W2805890484 modified "2023-09-27" @default.
• W2805890484 title "Comparative sensitivity of the test with tuberculosis recombinant allergen, containing ESAT6-CFP10 protein, and Mantoux test with 2 TU PPD-L in newly diagnosed tuberculosis children and adolescents in Moscow" @default.
• W2805890484 cites W1985860622 @default.
• W2805890484 cites W1989604051 @default.
• W2805890484 cites W1999823349 @default.
• W2805890484 cites W2033397726 @default.
• W2805890484 cites W2042792659 @default.
• W2805890484 cites W2067623049 @default.
• W2805890484 cites W2097586979 @default.
• W2805890484 cites W2104577284 @default.
• W2805890484 cites W2104715392 @default.
• W2805890484 cites W2107614420 @default.
• W2805890484 cites W2108723412 @default.
• W2805890484 cites W2110241349 @default.
• W2805890484 cites W2113243225 @default.
• W2805890484 cites W2132180171 @default.
• W2805890484 cites W2141090053 @default.
• W2805890484 cites W2147717316 @default.
• W2805890484 cites W2154501280 @default.
• W2805890484 cites W2165801752 @default.
• W2805890484 cites W2168466885 @default.
• W2805890484 cites W2184272173 @default.
• W2805890484 cites W2210413207 @default.
• W2805890484 cites W2292693477 @default.
• W2805890484 cites W2585399699 @default.
• W2805890484 doi "https://doi.org/10.1101/343665" @default.
• W2805890484 hasPublicationYear "2018" @default.
• W2805890484 type Work @default.
• W2805890484 sameAs 2805890484 @default.
• W2805890484 citedByCount "1" @default.
• W2805890484 countsByYear W28058904842023 @default.
• W2805890484 crossrefType "posted-content" @default.
• W2805890484 hasAuthorship W2805890484A5017416770 @default.
• W2805890484 hasAuthorship W2805890484A5034774633 @default.
• W2805890484 hasAuthorship W2805890484A5066044454 @default.
• W2805890484 hasAuthorship W2805890484A5077449451 @default.
• W2805890484 hasBestOaLocation W28058904841 @default.
• W2805890484 hasConcept C126322002 @default.
• W2805890484 hasConcept C142724271 @default.
• W2805890484 hasConcept C203014093 @default.
• W2805890484 hasConcept C2776247216 @default.
• W2805890484 hasConcept C2777913248 @default.
• W2805890484 hasConcept C2777975735 @default.
• W2805890484 hasConcept C2781069245 @default.
• W2805890484 hasConcept C2992250361 @default.
• W2805890484 hasConcept C71924100 @default.
• W2805890484 hasConcept C90924648 @default.
• W2805890484 hasConceptScore W2805890484C126322002 @default.
• W2805890484 hasConceptScore W2805890484C142724271 @default.
• W2805890484 hasConceptScore W2805890484C203014093 @default.
• W2805890484 hasConceptScore W2805890484C2776247216 @default.
• W2805890484 hasConceptScore W2805890484C2777913248 @default.
• W2805890484 hasConceptScore W2805890484C2777975735 @default.
• W2805890484 hasConceptScore W2805890484C2781069245 @default.
• W2805890484 hasConceptScore W2805890484C2992250361 @default.
• W2805890484 hasConceptScore W2805890484C71924100 @default.
• W2805890484 hasConceptScore W2805890484C90924648 @default.
• W2805890484 hasLocation W28058904841 @default.
• W2805890484 hasLocation W28058904842 @default.
• W2805890484 hasLocation W28058904843 @default.
• W2805890484 hasOpenAccess W2805890484 @default.
• W2805890484 hasPrimaryLocation W28058904841 @default.
• W2805890484 hasRelatedWork W2133562534 @default.
• W2805890484 hasRelatedWork W2164136796 @default.
• W2805890484 hasRelatedWork W2167331916 @default.
• W2805890484 hasRelatedWork W2171627501 @default.
• W2805890484 hasRelatedWork W2349894740 @default.
• W2805890484 hasRelatedWork W2761385502 @default.
• W2805890484 hasRelatedWork W2788398649 @default.
• W2805890484 hasRelatedWork W2903273826 @default.
• W2805890484 hasRelatedWork W2904701318 @default.
• W2805890484 hasRelatedWork W3179930708 @default.
• W2805890484 isParatext "false" @default.
• W2805890484 isRetracted "false" @default.
• W2805890484 magId "2805890484" @default.
• W2805890484 workType "article" @default.