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- W2805894637 abstract "Vitamin D receptor (VDR) and its ligand Vitamin D, play a crucial role in regulating multiple pathways for maintaining vascular health. The present study aimed at evaluating whether single nucleotide polymorphisms in VDR gene were associated with susceptibility to vascular dementia (VaD) due to cerebral small vessel disease (SVD). A total of 644 subjects (302 patients diagnosed with cerebral SVD-associated VaD and 342, age- and gender-matched healthy controls) were genotyped for VDR gene variants, FokI, ApaI, TaqI and BsmI, by PCR-RFLP method. Among the 4 examined VDR variants, the presence of the minor allele (Ff+ff vs FF) of FokI variant increased the risk for cerebral SVD by 1.5-fold in men (p = 0.047). Serum 25-hydroxyvitamin D [25(OH)D] was lower in subjects having the FokI ff genotype compared to those with the FF genotype (p = 0.044). Moreover, in subjects with low serum 25(OH)D the presence of ff genotype increased the odds of SVD by 2.5 folds (p = 0.041). ApaI polymorphism decreased the risk of cerebral SVD in women. The distribution of TaqI and BsmI variants were not significantly different between patients and controls. Further studies in large cohorts are necessary to validate the role of FokI polymorphism in cerebral SVD and VaD etiopathogenesis." @default.
- W2805894637 created "2018-06-13" @default.
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- W2805894637 date "2018-08-01" @default.
- W2805894637 modified "2023-10-13" @default.
- W2805894637 title "Vitamin D receptor ( VDR ) gene polymorphism and vascular dementia due to cerebral small vessel disease in an Asian Indian cohort" @default.
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- W2805894637 doi "https://doi.org/10.1016/j.jns.2018.05.025" @default.
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