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• W2805910384 abstract "This letter describes a simple surface modification strategy based on a single-step electrochemical anodization towards generating dual micro- and nano-rough horizontally-aligned TiO2 nanopores on the surface of clinically utilized micro-grooved titanium implants. Primary macrophages, osteoblasts and fibroblasts were cultured on the nano-engineered implants, and it was demonstrated that the modified surfaces selectively reduced the proliferation of macrophages (immunomodulation), while augmenting the activity of osteoblasts (osseo-integration) and fibroblasts (soft-tissue integration). Additionally, the mechanically robust nanopores also stimulated osteoblast and fibroblast adhesion, attachment and alignment along the direction of the pores/grooves, while macrophages remained oval-shaped and sparsely distributed. This study for the first time reports the use of cost-effectively prepared nano-engineered titanium surface via anodization, with aligned multi-scale micro/nano features for selective cellular bioactivity, without the use of any therapeutics." @default.
• W2805910384 created "2018-06-13" @default.
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• W2805910384 date "2018-10-01" @default.
• W2805910384 modified "2023-10-06" @default.
• W2805910384 title "Titania nanopores with dual micro-/nano-topography for selective cellular bioactivity" @default.
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• W2805910384 doi "https://doi.org/10.1016/j.msec.2018.05.075" @default.
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