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- W2805911102 abstract "ICD-85 is a combination of three poly-peptides, ranging from 10,000 to 30,000 Dalton, derived from the venoms of an Iranian brown snake (Agkistrodon halys) and a yellow scorpion (Hemiscorpius lepturus) . Labeling of this ICD-85 was successfully achieved with 99m Tc, through direct method using SnF 2 as reducing agent. Labeled ICD-85 was injected into mice to determine the excretion pathway. The results show that the maximum labeling yield (>75%) was obtained by using 30 μg of ICD-85 in phosphate buffer (60 μl, pH 7.1) at room temperature. Bio-distribution studies with radiolabeled ICD-85 shows moderate clearance of the complex from blood. The improvement of the immunotherapeutic treatment of cancer requires a better knowledge of the biological actions of the ICD-85 since tissue distribution studies are very important for clinical purpose." @default.
- W2805911102 created "2018-06-13" @default.
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- W2805911102 date "2018-03-13" @default.
- W2805911102 modified "2023-09-25" @default.
- W2805911102 title "Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice" @default.
- W2805911102 doi "https://doi.org/10.22037/jps.v9i2.18792" @default.
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