Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805964802> ?p ?o ?g. }
- W2805964802 endingPage "218" @default.
- W2805964802 startingPage "212" @default.
- W2805964802 abstract "Diabetic retinopathy (DR) remains a leading cause of blindness in adults with diabetes mellitus. The pathogenesis of DR is a multifactorial process, and excessive oxidative stress and apoptosis in retinal endothelial cells (RECs) play vital roles. In this study, RECs were treated with 25 mM glucose for three days, and we found that miR-145 was significantly downregulated in high glucose (HG)-treated RECs. Overexpression of miR-145 attenuated the HG-induced apoptosis, oxidative stress and inflammatory cytokines secretion in RECs. Besides, miR-145 overexpression also attenuated the increased TLR4 expression and NF-κB p65 nuclear translocation in HG-treated RECs. Luciferase reporter assay showed that miR-145 could specifically bind to the 3'UTR of TLR4, and overexpression of TLR4 abrogated the beneficial effects of miR-145 in HG-treated RECs. Therefore we suggested that miR-145 might be a potential therapeutic target for DR." @default.
- W2805964802 created "2018-06-13" @default.
- W2805964802 creator A5036423556 @default.
- W2805964802 creator A5082640513 @default.
- W2805964802 date "2018-08-01" @default.
- W2805964802 modified "2023-10-18" @default.
- W2805964802 title "MicroRNA-145 attenuates high glucose-induced oxidative stress and inflammation in retinal endothelial cells through regulating TLR4/NF-κB signaling" @default.
- W2805964802 cites W144423133 @default.
- W2805964802 cites W2012177783 @default.
- W2805964802 cites W2026570544 @default.
- W2805964802 cites W2047640394 @default.
- W2805964802 cites W2058052477 @default.
- W2805964802 cites W2083381199 @default.
- W2805964802 cites W2089057070 @default.
- W2805964802 cites W2090169194 @default.
- W2805964802 cites W2093752517 @default.
- W2805964802 cites W2095953797 @default.
- W2805964802 cites W2107277218 @default.
- W2805964802 cites W2120276758 @default.
- W2805964802 cites W2158704106 @default.
- W2805964802 cites W2160121103 @default.
- W2805964802 cites W2161948537 @default.
- W2805964802 cites W2234307896 @default.
- W2805964802 cites W2277947619 @default.
- W2805964802 cites W2297996952 @default.
- W2805964802 cites W2397533064 @default.
- W2805964802 cites W2626012745 @default.
- W2805964802 cites W575331073 @default.
- W2805964802 doi "https://doi.org/10.1016/j.lfs.2018.06.005" @default.
- W2805964802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29883722" @default.
- W2805964802 hasPublicationYear "2018" @default.
- W2805964802 type Work @default.
- W2805964802 sameAs 2805964802 @default.
- W2805964802 citedByCount "61" @default.
- W2805964802 countsByYear W28059648022018 @default.
- W2805964802 countsByYear W28059648022019 @default.
- W2805964802 countsByYear W28059648022020 @default.
- W2805964802 countsByYear W28059648022021 @default.
- W2805964802 countsByYear W28059648022022 @default.
- W2805964802 countsByYear W28059648022023 @default.
- W2805964802 crossrefType "journal-article" @default.
- W2805964802 hasAuthorship W2805964802A5036423556 @default.
- W2805964802 hasAuthorship W2805964802A5082640513 @default.
- W2805964802 hasConcept C104317684 @default.
- W2805964802 hasConcept C126322002 @default.
- W2805964802 hasConcept C134018914 @default.
- W2805964802 hasConcept C145059251 @default.
- W2805964802 hasConcept C164027704 @default.
- W2805964802 hasConcept C190283241 @default.
- W2805964802 hasConcept C2776070231 @default.
- W2805964802 hasConcept C2776151105 @default.
- W2805964802 hasConcept C2776914184 @default.
- W2805964802 hasConcept C2777730290 @default.
- W2805964802 hasConcept C2779829184 @default.
- W2805964802 hasConcept C2780942790 @default.
- W2805964802 hasConcept C502942594 @default.
- W2805964802 hasConcept C55493867 @default.
- W2805964802 hasConcept C555293320 @default.
- W2805964802 hasConcept C62478195 @default.
- W2805964802 hasConcept C71924100 @default.
- W2805964802 hasConcept C86803240 @default.
- W2805964802 hasConcept C95444343 @default.
- W2805964802 hasConceptScore W2805964802C104317684 @default.
- W2805964802 hasConceptScore W2805964802C126322002 @default.
- W2805964802 hasConceptScore W2805964802C134018914 @default.
- W2805964802 hasConceptScore W2805964802C145059251 @default.
- W2805964802 hasConceptScore W2805964802C164027704 @default.
- W2805964802 hasConceptScore W2805964802C190283241 @default.
- W2805964802 hasConceptScore W2805964802C2776070231 @default.
- W2805964802 hasConceptScore W2805964802C2776151105 @default.
- W2805964802 hasConceptScore W2805964802C2776914184 @default.
- W2805964802 hasConceptScore W2805964802C2777730290 @default.
- W2805964802 hasConceptScore W2805964802C2779829184 @default.
- W2805964802 hasConceptScore W2805964802C2780942790 @default.
- W2805964802 hasConceptScore W2805964802C502942594 @default.
- W2805964802 hasConceptScore W2805964802C55493867 @default.
- W2805964802 hasConceptScore W2805964802C555293320 @default.
- W2805964802 hasConceptScore W2805964802C62478195 @default.
- W2805964802 hasConceptScore W2805964802C71924100 @default.
- W2805964802 hasConceptScore W2805964802C86803240 @default.
- W2805964802 hasConceptScore W2805964802C95444343 @default.
- W2805964802 hasLocation W28059648021 @default.
- W2805964802 hasLocation W28059648022 @default.
- W2805964802 hasOpenAccess W2805964802 @default.
- W2805964802 hasPrimaryLocation W28059648021 @default.
- W2805964802 hasRelatedWork W1513368991 @default.
- W2805964802 hasRelatedWork W2062835892 @default.
- W2805964802 hasRelatedWork W2136469540 @default.
- W2805964802 hasRelatedWork W23057823 @default.
- W2805964802 hasRelatedWork W2903267326 @default.
- W2805964802 hasRelatedWork W2938573250 @default.
- W2805964802 hasRelatedWork W3012974675 @default.
- W2805964802 hasRelatedWork W3029119452 @default.
- W2805964802 hasRelatedWork W3085250489 @default.
- W2805964802 hasRelatedWork W3200327297 @default.
- W2805964802 hasVolume "207" @default.
- W2805964802 isParatext "false" @default.
- W2805964802 isRetracted "false" @default.