FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2805984246> ?p ?o ?g. }

• W2805984246 endingPage "2539" @default.
• W2805984246 startingPage "2530" @default.
• W2805984246 abstract "Noncoding small RNAs (sRNAs) are known to play a key role in regulating diverse cellular processes, and their dysregulation is linked to various diseases such as cancer. Such diseases are also marked by phenotypic heterogeneity, which is often driven by the intrinsic stochasticity of gene expression. Correspondingly, there is significant interest in developing quantitative models focusing on the interplay between stochastic gene expression and regulation by sRNAs. We consider the canonical model of regulation of stochastic gene expression by sRNAs, wherein interaction between constitutively expressed sRNAs and mRNAs leads to stoichiometric mutual degradation. The exact solution of this model is analytically intractable given the nonlinear interaction term between sRNAs and mRNAs, and theoretical approaches typically invoke the mean-field approximation. However, mean-field results are inaccurate in the limit of strong interactions and low abundances; thus, alternative theoretical approaches are needed. In this work, we obtain analytical results for the canonical model of regulation of stochastic gene expression by sRNAs in the strong interaction limit. We derive analytical results for the steady-state generating function of the joint distribution of mRNAs and sRNAs in the limit of strong interactions and use the results derived to obtain analytical expressions characterizing the corresponding protein steady-state distribution. The results obtained can serve as building blocks for the analysis of genetic circuits involving sRNAs and provide new insights into the role of sRNAs in regulating stochastic gene expression in the limit of strong interactions." @default.
• W2805984246 created "2018-06-13" @default.
• W2805984246 creator A5004129233 @default.
• W2805984246 creator A5035364787 @default.
• W2805984246 creator A5048266570 @default.
• W2805984246 date "2018-06-01" @default.
• W2805984246 modified "2023-10-12" @default.
• W2805984246 title "Stochastic Modeling of Gene Regulation by Noncoding Small RNAs in the Strong Interaction Limit" @default.
• W2805984246 cites W1509435176 @default.
• W2805984246 cites W1648301895 @default.
• W2805984246 cites W1972206112 @default.
• W2805984246 cites W1978750558 @default.
• W2805984246 cites W1987807339 @default.
• W2805984246 cites W1989534009 @default.
• W2805984246 cites W2005361347 @default.
• W2805984246 cites W2017718158 @default.
• W2805984246 cites W2018435536 @default.
• W2805984246 cites W2020596227 @default.
• W2805984246 cites W2040851473 @default.
• W2805984246 cites W2043946672 @default.
• W2805984246 cites W2044692345 @default.
• W2805984246 cites W2074087817 @default.
• W2805984246 cites W2077336113 @default.
• W2805984246 cites W2080252570 @default.
• W2805984246 cites W2088631531 @default.
• W2805984246 cites W2091198609 @default.
• W2805984246 cites W2094282853 @default.
• W2805984246 cites W2096705138 @default.
• W2805984246 cites W2101804051 @default.
• W2805984246 cites W2103354991 @default.
• W2805984246 cites W2108141605 @default.
• W2805984246 cites W2108631115 @default.
• W2805984246 cites W2114870653 @default.
• W2805984246 cites W2120563389 @default.
• W2805984246 cites W2122121413 @default.
• W2805984246 cites W2143145944 @default.
• W2805984246 cites W2149242848 @default.
• W2805984246 cites W2155418451 @default.
• W2805984246 cites W2163184432 @default.
• W2805984246 cites W2163351681 @default.
• W2805984246 cites W2171280873 @default.
• W2805984246 cites W2171296186 @default.
• W2805984246 cites W2171425427 @default.
• W2805984246 cites W2268557312 @default.
• W2805984246 cites W2537396433 @default.
• W2805984246 cites W2579662936 @default.
• W2805984246 cites W2581249024 @default.
• W2805984246 cites W2768096340 @default.
• W2805984246 cites W3100822090 @default.
• W2805984246 doi "https://doi.org/10.1016/j.bpj.2018.04.044" @default.
• W2805984246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6129477" @default.
• W2805984246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29874604" @default.
• W2805984246 hasPublicationYear "2018" @default.
• W2805984246 type Work @default.
• W2805984246 sameAs 2805984246 @default.
• W2805984246 citedByCount "6" @default.
• W2805984246 countsByYear W28059842462019 @default.
• W2805984246 countsByYear W28059842462020 @default.
• W2805984246 countsByYear W28059842462022 @default.
• W2805984246 crossrefType "journal-article" @default.
• W2805984246 hasAuthorship W2805984246A5004129233 @default.
• W2805984246 hasAuthorship W2805984246A5035364787 @default.
• W2805984246 hasAuthorship W2805984246A5048266570 @default.
• W2805984246 hasBestOaLocation W28059842461 @default.
• W2805984246 hasConcept C104317684 @default.
• W2805984246 hasConcept C105795698 @default.
• W2805984246 hasConcept C121332964 @default.
• W2805984246 hasConcept C121864883 @default.
• W2805984246 hasConcept C127491075 @default.
• W2805984246 hasConcept C134306372 @default.
• W2805984246 hasConcept C150194340 @default.
• W2805984246 hasConcept C151201525 @default.
• W2805984246 hasConcept C165864922 @default.
• W2805984246 hasConcept C33923547 @default.
• W2805984246 hasConcept C54355233 @default.
• W2805984246 hasConcept C70721500 @default.
• W2805984246 hasConcept C86803240 @default.
• W2805984246 hasConceptScore W2805984246C104317684 @default.
• W2805984246 hasConceptScore W2805984246C105795698 @default.
• W2805984246 hasConceptScore W2805984246C121332964 @default.
• W2805984246 hasConceptScore W2805984246C121864883 @default.
• W2805984246 hasConceptScore W2805984246C127491075 @default.
• W2805984246 hasConceptScore W2805984246C134306372 @default.
• W2805984246 hasConceptScore W2805984246C150194340 @default.
• W2805984246 hasConceptScore W2805984246C151201525 @default.
• W2805984246 hasConceptScore W2805984246C165864922 @default.
• W2805984246 hasConceptScore W2805984246C33923547 @default.
• W2805984246 hasConceptScore W2805984246C54355233 @default.
• W2805984246 hasConceptScore W2805984246C70721500 @default.
• W2805984246 hasConceptScore W2805984246C86803240 @default.
• W2805984246 hasFunder F4320306076 @default.
• W2805984246 hasFunder F4320310274 @default.
• W2805984246 hasFunder F4320313188 @default.
• W2805984246 hasFunder F4320332161 @default.
• W2805984246 hasIssue "11" @default.
• W2805984246 hasLocation W28059842461 @default.
• W2805984246 hasLocation W28059842462 @default.
• W2805984246 hasLocation W28059842463 @default.

• next