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- W2806007645 abstract "Abstract In November 2013, posaconazole delayed release ( DR ) tablets were approved by the FDA with the labeled dose of 300 mg daily for fungal prophylaxis. There are no studies demonstrating the appropriate dose in lung transplant recipients ( LTR ). We performed a 2‐center retrospective cohort study of LTR taking posaconazole DR tablets for prophylaxis between January 2014 and January 2017. Mean serum trough concentrations and percentage of measurements ≥0.7 mcg/ mL were compared by daily dose. Forty‐nine subjects with 156 steady state serum posaconazole concentrations were included. There was a significant difference in percentage of first measured concentration ≥0.7 mcg/ mL by initial daily dose ( P = .04). The mean serum posaconazole concentration by dose was 0.9 (±0.42) mcg/ mL for 100 mg daily, 1.66 (±0.91) mcg/ mL for 200 mg daily, 2.39 (±1.49) mcg/ mL for 300 mg daily, and 1.75 (±0.21) mcg/ mL for 400 mg daily ( P < .001). Mean concentrations were at goal in 63.3%, 96.9%, 94.9%, and 100% of subjects taking 100 mg, 200 mg, 300 mg, and 400 mg daily respectively ( P = .04). Our results suggest that doses less than 300 mg daily of posaconazole DR tablets may be adequate to achieve target serum concentrations in LTR . Larger studies are needed to confirm these findings." @default.
- W2806007645 created "2018-06-13" @default.
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- W2806007645 date "2018-06-15" @default.
- W2806007645 modified "2023-10-16" @default.
- W2806007645 title "Low dose posaconazole delayed release tablets for fungal prophylaxis in lung transplant recipients" @default.
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- W2806007645 doi "https://doi.org/10.1111/ctr.13300" @default.
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