Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806010487> ?p ?o ?g. }
- W2806010487 endingPage "353" @default.
- W2806010487 startingPage "341" @default.
- W2806010487 abstract "N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell disease (SCD) symptoms. All of the compounds demonstrated the capacity to releasing nitric oxide at different levels ranging from 0.8 to 30.1%, in vivo analgesic activity and ability to reduce TNF-α levels in the supernatants of monocyte cultures. The most active compound (8b) protected 50.1% against acetic acid-induced abdominal constrictions, while dipyrone, which was used as a control only protected 35%. Compounds 8a and 8b inhibited ADP-induced platelet aggregation by 84% and 76.1%, respectively. Both compounds increased γ-globin in K562 cells at 100 μM. The mechanisms involved in the γ-globin increase are related to the acetylation of histones H3 and H4 that is induced by these compounds. In vitro, the most promising compound (8b) was not cytotoxic, mutagenic and genotoxic." @default.
- W2806010487 created "2018-06-13" @default.
- W2806010487 creator A5008123852 @default.
- W2806010487 creator A5018378505 @default.
- W2806010487 creator A5019090807 @default.
- W2806010487 creator A5019463458 @default.
- W2806010487 creator A5021207027 @default.
- W2806010487 creator A5026659281 @default.
- W2806010487 creator A5028059814 @default.
- W2806010487 creator A5029221053 @default.
- W2806010487 creator A5036685908 @default.
- W2806010487 creator A5047656780 @default.
- W2806010487 creator A5053053577 @default.
- W2806010487 creator A5054057703 @default.
- W2806010487 creator A5056125856 @default.
- W2806010487 creator A5061380286 @default.
- W2806010487 creator A5067713063 @default.
- W2806010487 creator A5068555881 @default.
- W2806010487 creator A5069259608 @default.
- W2806010487 creator A5085797426 @default.
- W2806010487 date "2018-06-01" @default.
- W2806010487 modified "2023-10-16" @default.
- W2806010487 title "Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation" @default.
- W2806010487 cites W1479760463 @default.
- W2806010487 cites W1522153085 @default.
- W2806010487 cites W1921966331 @default.
- W2806010487 cites W1963558418 @default.
- W2806010487 cites W1971109751 @default.
- W2806010487 cites W1975695158 @default.
- W2806010487 cites W1977708103 @default.
- W2806010487 cites W1978464782 @default.
- W2806010487 cites W1981946882 @default.
- W2806010487 cites W1983940797 @default.
- W2806010487 cites W1986796600 @default.
- W2806010487 cites W1990425278 @default.
- W2806010487 cites W1990599619 @default.
- W2806010487 cites W1992895804 @default.
- W2806010487 cites W1993026652 @default.
- W2806010487 cites W2003729388 @default.
- W2806010487 cites W2011527402 @default.
- W2806010487 cites W2014420716 @default.
- W2806010487 cites W2018683912 @default.
- W2806010487 cites W2019381418 @default.
- W2806010487 cites W2023275162 @default.
- W2806010487 cites W2024264346 @default.
- W2806010487 cites W2026294448 @default.
- W2806010487 cites W2026645409 @default.
- W2806010487 cites W2035949542 @default.
- W2806010487 cites W2040603499 @default.
- W2806010487 cites W2047000831 @default.
- W2806010487 cites W2051690250 @default.
- W2806010487 cites W2051932272 @default.
- W2806010487 cites W2051985758 @default.
- W2806010487 cites W2053173208 @default.
- W2806010487 cites W2053495832 @default.
- W2806010487 cites W2053677349 @default.
- W2806010487 cites W2055848370 @default.
- W2806010487 cites W2061188498 @default.
- W2806010487 cites W2069093904 @default.
- W2806010487 cites W2070597848 @default.
- W2806010487 cites W2071370806 @default.
- W2806010487 cites W2074901521 @default.
- W2806010487 cites W2078328099 @default.
- W2806010487 cites W2090462077 @default.
- W2806010487 cites W2092629964 @default.
- W2806010487 cites W2093185747 @default.
- W2806010487 cites W2095577749 @default.
- W2806010487 cites W2095670455 @default.
- W2806010487 cites W2126902508 @default.
- W2806010487 cites W2128779133 @default.
- W2806010487 cites W2148278154 @default.
- W2806010487 cites W2149069545 @default.
- W2806010487 cites W2170845283 @default.
- W2806010487 cites W2170995347 @default.
- W2806010487 cites W2300898907 @default.
- W2806010487 cites W2329123120 @default.
- W2806010487 cites W2409396011 @default.
- W2806010487 cites W4211186710 @default.
- W2806010487 cites W4229793952 @default.
- W2806010487 cites W4249969224 @default.
- W2806010487 cites W635179157 @default.
- W2806010487 cites W83314201 @default.
- W2806010487 doi "https://doi.org/10.1016/j.ejmech.2018.05.008" @default.
- W2806010487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29852459" @default.
- W2806010487 hasPublicationYear "2018" @default.
- W2806010487 type Work @default.
- W2806010487 sameAs 2806010487 @default.
- W2806010487 citedByCount "9" @default.
- W2806010487 countsByYear W28060104872019 @default.
- W2806010487 countsByYear W28060104872020 @default.
- W2806010487 countsByYear W28060104872021 @default.
- W2806010487 countsByYear W28060104872022 @default.
- W2806010487 countsByYear W28060104872023 @default.
- W2806010487 crossrefType "journal-article" @default.
- W2806010487 hasAuthorship W2806010487A5008123852 @default.
- W2806010487 hasAuthorship W2806010487A5018378505 @default.
- W2806010487 hasAuthorship W2806010487A5019090807 @default.
- W2806010487 hasAuthorship W2806010487A5019463458 @default.