Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806012805> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2806012805 endingPage "e200" @default.
- W2806012805 startingPage "e200" @default.
- W2806012805 abstract "Objective: The reduced form of nicotinamide adenine dinucleotide (NADH) is involved in many redox reactions, including those related to the energy production in mitochondria when NADH is oxidized to NAD+. Live cell NADH content can be measured as a 460-nm autofluorescence after ultraviolet excitation. Hypoxia/anoxia during tissue ischemia ceases aerobic metabolism and leads to NADH accumulation – this effect is used by the flow-mediated skin fluorescence (FMSF) method measuring forearm skin fluorescence before, during and after short-lasting occlusion of the brachial artery caused by an inflated arm blood pressure cuff. There are many potential factors which might influence the NADH metabolism during ischemia and reperfusion. We aimed to study the relationship between body mass index (BMI) and the dynamic changes in the skin NADH during ischemia and reperfusion in healthy people. Design and method: Fifty eight healthy people (36 women) within BMI range of 17.4–32.9 kg/m2 underwent measurement of skin fluorescence at the 460 nm light length (Angioexpert, Angionica, Poland) during 3-minute followed by a 100-second forearm ischaemia caused by inflation of the brachial pressure cuff to the pressure 60 mmHg above each participant's systolic blood pressure, and then a 3-minute reperfusion. The association between BMI and values quantifying areas under the fluorescence curve during ischemia (IAUC) and reperfusion (RAUC) as well as half-times of fluorescence increase during ischemia (tI) and fluorescence recovery during post-ischemic reperfusion (tR) was analyzed by the nonparametric Spearman correlation. Results: Mean age of studied participants was 23.7+/−7.9 years, their BMI 22.8+/−3.0 kg/m2, IAUC 5.7+/−4.3 %s, RAUC 5.7+/- 4.3%s, tI 36.8+/−25.1 s, and tR 28.2+/−11.2 s. BMI was significantly and positively correlated with IR (rho = 0.32; p = 0.0136) and tR (rho = 0.39; p = 0.0026), and negatively with tI (rho = −0.28; p = 0,0334). Conclusions: There is a significant correlation between BMI and NADH dynamic changes during transient, short-lasting ischemia and reperfusion of the forearm skin. Healthy people with increased BMI present larger and faster increase of NADH content during ischemia, and a delayed NADH recovery during post-ischemic reperfusion. Further physiological and clinical investigations are required to explore these findings." @default.
- W2806012805 created "2018-06-13" @default.
- W2806012805 creator A5006433723 @default.
- W2806012805 creator A5019233672 @default.
- W2806012805 creator A5020621812 @default.
- W2806012805 creator A5030751074 @default.
- W2806012805 creator A5034938840 @default.
- W2806012805 creator A5044321055 @default.
- W2806012805 creator A5046986371 @default.
- W2806012805 creator A5082227842 @default.
- W2806012805 date "2018-06-01" @default.
- W2806012805 modified "2023-09-27" @default.
- W2806012805 title "SKIN FLUORESCENCE RESPONSE TO FOREARM ISCHEMIA AND REPERFUSION IS RELATED TO BODY MASS INDEX IN HEALTHY PEOPLE" @default.
- W2806012805 doi "https://doi.org/10.1097/01.hjh.0000539558.10567.f1" @default.
- W2806012805 hasPublicationYear "2018" @default.
- W2806012805 type Work @default.
- W2806012805 sameAs 2806012805 @default.
- W2806012805 citedByCount "0" @default.
- W2806012805 crossrefType "journal-article" @default.
- W2806012805 hasAuthorship W2806012805A5006433723 @default.
- W2806012805 hasAuthorship W2806012805A5019233672 @default.
- W2806012805 hasAuthorship W2806012805A5020621812 @default.
- W2806012805 hasAuthorship W2806012805A5030751074 @default.
- W2806012805 hasAuthorship W2806012805A5034938840 @default.
- W2806012805 hasAuthorship W2806012805A5044321055 @default.
- W2806012805 hasAuthorship W2806012805A5046986371 @default.
- W2806012805 hasAuthorship W2806012805A5082227842 @default.
- W2806012805 hasConcept C121332964 @default.
- W2806012805 hasConcept C126322002 @default.
- W2806012805 hasConcept C134018914 @default.
- W2806012805 hasConcept C141071460 @default.
- W2806012805 hasConcept C142724271 @default.
- W2806012805 hasConcept C164705383 @default.
- W2806012805 hasConcept C179687394 @default.
- W2806012805 hasConcept C181199279 @default.
- W2806012805 hasConcept C185592680 @default.
- W2806012805 hasConcept C2780017030 @default.
- W2806012805 hasConcept C2780214079 @default.
- W2806012805 hasConcept C541997718 @default.
- W2806012805 hasConcept C55493867 @default.
- W2806012805 hasConcept C62520636 @default.
- W2806012805 hasConcept C71924100 @default.
- W2806012805 hasConcept C75520062 @default.
- W2806012805 hasConcept C84393581 @default.
- W2806012805 hasConcept C91881484 @default.
- W2806012805 hasConceptScore W2806012805C121332964 @default.
- W2806012805 hasConceptScore W2806012805C126322002 @default.
- W2806012805 hasConceptScore W2806012805C134018914 @default.
- W2806012805 hasConceptScore W2806012805C141071460 @default.
- W2806012805 hasConceptScore W2806012805C142724271 @default.
- W2806012805 hasConceptScore W2806012805C164705383 @default.
- W2806012805 hasConceptScore W2806012805C179687394 @default.
- W2806012805 hasConceptScore W2806012805C181199279 @default.
- W2806012805 hasConceptScore W2806012805C185592680 @default.
- W2806012805 hasConceptScore W2806012805C2780017030 @default.
- W2806012805 hasConceptScore W2806012805C2780214079 @default.
- W2806012805 hasConceptScore W2806012805C541997718 @default.
- W2806012805 hasConceptScore W2806012805C55493867 @default.
- W2806012805 hasConceptScore W2806012805C62520636 @default.
- W2806012805 hasConceptScore W2806012805C71924100 @default.
- W2806012805 hasConceptScore W2806012805C75520062 @default.
- W2806012805 hasConceptScore W2806012805C84393581 @default.
- W2806012805 hasConceptScore W2806012805C91881484 @default.
- W2806012805 hasIssue "Supplement 1" @default.
- W2806012805 hasLocation W28060128051 @default.
- W2806012805 hasOpenAccess W2806012805 @default.
- W2806012805 hasPrimaryLocation W28060128051 @default.
- W2806012805 hasRelatedWork W1505458153 @default.
- W2806012805 hasRelatedWork W1966234050 @default.
- W2806012805 hasRelatedWork W2091445491 @default.
- W2806012805 hasRelatedWork W2146349004 @default.
- W2806012805 hasRelatedWork W2171089442 @default.
- W2806012805 hasRelatedWork W2287093343 @default.
- W2806012805 hasRelatedWork W2897222345 @default.
- W2806012805 hasRelatedWork W2898883776 @default.
- W2806012805 hasRelatedWork W2964874449 @default.
- W2806012805 hasRelatedWork W4378649163 @default.
- W2806012805 hasVolume "36" @default.
- W2806012805 isParatext "false" @default.
- W2806012805 isRetracted "false" @default.
- W2806012805 magId "2806012805" @default.
- W2806012805 workType "article" @default.