FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806021934> ?p ?o ?g. }

• W2806021934 endingPage "2086" @default.
• W2806021934 startingPage "2079" @default.
• W2806021934 abstract "We conducted a nested case-control study to study the association between antidiabetic treatments (alone or in combination) use and fracture risk among incident type 2 Diabetes mellitus patients. We found an increased risk of bone fracture with insulin therapy compared to metformin monotherapy.Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility fractures, to which antidiabetic therapies may contribute. We aimed to characterize the risk of fracture associated with different antidiabetic treatments as usually prescribed to T2DM patients in actual practice conditions.A case-control study was nested within a cohort of incident T2DM patients registered in 2006-2012 in the Information System for Research Development in Primary Care (Catalan acronym, SIDIAP), a database which includes records for > 5.5 million patients in Catalonia (Spain). Each case (incident major osteoporotic fracture) was risk-set matched with up to five same-sex controls by calendar year of T2DM diagnosis and year of birth (± 10 years). Study exposure included previous use of all antidiabetic medications (alone or in combination), as dispensed in the 6 months before the index date, with metformin (MTF) monotherapy, the most commonly used drug, as a reference group (active comparator).Data on 12,277 T2DM patients (2049 cases and 10,228 controls) were analyzed. Insulin use was associated with increased fracture risk (adjusted OR 1.63 (95% CI 1.30-2.04)), as was the combination of MTF and sulfonylurea (SU) (adjusted OR 1.29 (1.07-1.56)), compared with MTF monotherapy. Sensitivity analyses suggest possible causality for insulin therapy but not for the MTF + SU combination association. No significant association was found with any other antidiabetic medications.Insulin monotherapy was associated with an increased fracture risk compared to MTF monotherapy in T2DM patients. Fracture risk should be taken into account when starting a glucose-lowering drug as part of T2DM treatment." @default.
• W2806021934 created "2018-06-13" @default.
• W2806021934 creator A5008613527 @default.
• W2806021934 creator A5011949935 @default.
• W2806021934 creator A5012291664 @default.
• W2806021934 creator A5038076932 @default.
• W2806021934 creator A5052312125 @default.
• W2806021934 creator A5055738711 @default.
• W2806021934 creator A5069502074 @default.
• W2806021934 creator A5074675449 @default.
• W2806021934 creator A5084437931 @default.
• W2806021934 date "2018-06-02" @default.
• W2806021934 modified "2023-10-17" @default.
• W2806021934 title "Real-world antidiabetic drug use and fracture risk in 12,277 patients with type 2 diabetes mellitus: a nested case–control study" @default.
• W2806021934 cites W1607151225 @default.
• W2806021934 cites W1811061299 @default.
• W2806021934 cites W1822903338 @default.
• W2806021934 cites W1868502833 @default.
• W2806021934 cites W1996666687 @default.
• W2806021934 cites W2001033822 @default.
• W2806021934 cites W2002961599 @default.
• W2806021934 cites W2006573193 @default.
• W2806021934 cites W2006843224 @default.
• W2806021934 cites W2008679328 @default.
• W2806021934 cites W2011753046 @default.
• W2806021934 cites W2017963081 @default.
• W2806021934 cites W2019501773 @default.
• W2806021934 cites W2044288806 @default.
• W2806021934 cites W2065404058 @default.
• W2806021934 cites W2077755583 @default.
• W2806021934 cites W2091042653 @default.
• W2806021934 cites W2091272943 @default.
• W2806021934 cites W2099673402 @default.
• W2806021934 cites W2111178315 @default.
• W2806021934 cites W2112704642 @default.
• W2806021934 cites W2119004608 @default.
• W2806021934 cites W2122414041 @default.
• W2806021934 cites W2125637498 @default.
• W2806021934 cites W2133997722 @default.
• W2806021934 cites W2139091725 @default.
• W2806021934 cites W2147617075 @default.
• W2806021934 cites W2150333580 @default.
• W2806021934 cites W2154580171 @default.
• W2806021934 cites W2157048373 @default.
• W2806021934 cites W2516863452 @default.
• W2806021934 cites W2528036969 @default.
• W2806021934 cites W2542526844 @default.
• W2806021934 cites W2551825342 @default.
• W2806021934 cites W2594451671 @default.
• W2806021934 cites W2601331981 @default.
• W2806021934 cites W2626423768 @default.
• W2806021934 cites W4213412326 @default.
• W2806021934 doi "https://doi.org/10.1007/s00198-018-4581-y" @default.
• W2806021934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29860664" @default.
• W2806021934 hasPublicationYear "2018" @default.
• W2806021934 type Work @default.
• W2806021934 sameAs 2806021934 @default.
• W2806021934 citedByCount "35" @default.
• W2806021934 countsByYear W28060219342018 @default.
• W2806021934 countsByYear W28060219342019 @default.
• W2806021934 countsByYear W28060219342020 @default.
• W2806021934 countsByYear W28060219342021 @default.
• W2806021934 countsByYear W28060219342022 @default.
• W2806021934 crossrefType "journal-article" @default.
• W2806021934 hasAuthorship W2806021934A5008613527 @default.
• W2806021934 hasAuthorship W2806021934A5011949935 @default.
• W2806021934 hasAuthorship W2806021934A5012291664 @default.
• W2806021934 hasAuthorship W2806021934A5038076932 @default.
• W2806021934 hasAuthorship W2806021934A5052312125 @default.
• W2806021934 hasAuthorship W2806021934A5055738711 @default.
• W2806021934 hasAuthorship W2806021934A5069502074 @default.
• W2806021934 hasAuthorship W2806021934A5074675449 @default.
• W2806021934 hasAuthorship W2806021934A5084437931 @default.
• W2806021934 hasBestOaLocation W28060219342 @default.
• W2806021934 hasConcept C126322002 @default.
• W2806021934 hasConcept C134018914 @default.
• W2806021934 hasConcept C141071460 @default.
• W2806021934 hasConcept C165617652 @default.
• W2806021934 hasConcept C201903717 @default.
• W2806021934 hasConcept C2777180221 @default.
• W2806021934 hasConcept C2779306644 @default.
• W2806021934 hasConcept C2780323712 @default.
• W2806021934 hasConcept C2910068830 @default.
• W2806021934 hasConcept C44249647 @default.
• W2806021934 hasConcept C555293320 @default.
• W2806021934 hasConcept C71924100 @default.
• W2806021934 hasConcept C72563966 @default.
• W2806021934 hasConcept C82789193 @default.
• W2806021934 hasConceptScore W2806021934C126322002 @default.
• W2806021934 hasConceptScore W2806021934C134018914 @default.
• W2806021934 hasConceptScore W2806021934C141071460 @default.
• W2806021934 hasConceptScore W2806021934C165617652 @default.
• W2806021934 hasConceptScore W2806021934C201903717 @default.
• W2806021934 hasConceptScore W2806021934C2777180221 @default.
• W2806021934 hasConceptScore W2806021934C2779306644 @default.
• W2806021934 hasConceptScore W2806021934C2780323712 @default.
• W2806021934 hasConceptScore W2806021934C2910068830 @default.
• W2806021934 hasConceptScore W2806021934C44249647 @default.

• next