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• W2806041036 abstract "Objective: Many studies have shown the association ofsusceptibility to several cancers with gene encoding enzymes’polymorphisms which engage in xenobiotics’ biotransformation.In this study, the main purpose is to search the relation betweencytochrome P450 (CYP) 2D6* 4 polymorphisms and Polycythemiavera (PV) incidence in Turkish population.Materials and Methods: In this research article, 80Polycthemia vera (PV) cases and 76 control samples have beenused for the analysis of CYP 2D6* 4 polymorphism. The researchhas been performed by the methods of polymerase chain reaction(PCR)-restriction fragment length polymorphism (RFLP).Results: As a result, when patients and controls werecompared in terms of CYP 2D6* 4 poor metabolizer (PM) andheterozygous extensive metabolizer (HEM) genotype frequency,it has been found that the patients have 1.35% PM and 32.43%HEM frequency, and controls have 2.63% PM and 21.05% HEMfrequency. The correlation between the results of CYP 2D6genotype analysis and the risk of disease in patients and controlswas examined. We found that PM, HEM and extensive metabolizer(EM) genotypes were unrelated with the risk of PV (OR 0.51, 95%CI 0.04-5.71, OR 1.80, 95% CI 0.86-3.75, χ2 1.93, P: 0.164, OR0.61, 95% CI 0.30-1.24, χ2 1.40, P: 0.235).Conclusion: Our results suggested that the CYP 2D6*4 polymorphism, in the studied population, does not play animportant role in PV etiology." @default.
• W2806041036 created "2018-06-13" @default.
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• W2806041036 date "2018-06-05" @default.
• W2806041036 modified "2023-10-18" @default.
• W2806041036 title "Türk popülasyonunda Polisitemia vera hastalarında CYP 2D6*4 polimorfizmi" @default.
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• W2806041036 doi "https://doi.org/10.5472/marumj.430790" @default.
• W2806041036 hasPublicationYear "2018" @default.
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