FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806081567> ?p ?o ?g. }

• W2806081567 endingPage "225" @default.
• W2806081567 startingPage "216" @default.
• W2806081567 abstract "During gastrulation, one of the most important morphogenetic events in sea urchin embryogenesis, the gut bends toward the ventral side to form an open mouth. Although the involvement of transforming growth factor-β (TGF-β) signals in the cell-fate specification of the ectoderm and endoderm along the dorsal-ventral axis has been well reported, it remains unclear what controls the morphogenetic behavior of gut bending. Here, using two sea urchin species, Hemicentrotus pulcherrimus and Temnopleurus reevesii, we show that TGF-β signals are required for gut bending toward the ventral side. To search for the common morphogenetic cue in these two species, we initially confirmed the expression patterns of the dorsal-ventral regulatory TGF-β members, nodal, lefty, bmp2/4, and chordin, in T. reevesii because these factors are appropriate candidates to investigate the cue that starts gut bending, although genetic information about the body axes is entirely lacking in this species. Based on their expression patterns and a functional analysis of Nodal, the dorsal-ventral axis formation of T. reevesii is likely regulated by these TGF-β members, as in other sea urchins. When the Alk4/5/7 signal was inhibited by its specific inhibitor, SB431542, before the late gastrula stage of T. reevesii, the gut was extended straight toward the anterior tip region, although the ectodermal dorsal-ventral polarity was normal. By contrast, H. pulcherrimus gut bending was sensitive to SB431542 until the prism stage. These data clearly indicate that gut bending is commonly dependent on a TGF-β signal in sea urchins, but the timing of the response varies in different species." @default.
• W2806081567 created "2018-06-13" @default.
• W2806081567 creator A5003165688 @default.
• W2806081567 creator A5090831722 @default.
• W2806081567 date "2018-05-01" @default.
• W2806081567 modified "2023-09-25" @default.
• W2806081567 title "Transforming growth factor-β signal regulates gut bending in the sea urchin embryo" @default.
• W2806081567 cites W1499838764 @default.
• W2806081567 cites W1968068346 @default.
• W2806081567 cites W1983397556 @default.
• W2806081567 cites W1990786165 @default.
• W2806081567 cites W1992201077 @default.
• W2806081567 cites W1998300637 @default.
• W2806081567 cites W2008347468 @default.
• W2806081567 cites W2022014757 @default.
• W2806081567 cites W2023256299 @default.
• W2806081567 cites W2035246304 @default.
• W2806081567 cites W2049459220 @default.
• W2806081567 cites W2059364511 @default.
• W2806081567 cites W2064570026 @default.
• W2806081567 cites W2072190909 @default.
• W2806081567 cites W2081637236 @default.
• W2806081567 cites W2087919524 @default.
• W2806081567 cites W2092659352 @default.
• W2806081567 cites W2099491263 @default.
• W2806081567 cites W2101261864 @default.
• W2806081567 cites W2105537755 @default.
• W2806081567 cites W2113046040 @default.
• W2806081567 cites W2117814548 @default.
• W2806081567 cites W2120794655 @default.
• W2806081567 cites W2147643725 @default.
• W2806081567 cites W2185263368 @default.
• W2806081567 cites W2339393519 @default.
• W2806081567 doi "https://doi.org/10.1111/dgd.12434" @default.
• W2806081567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29878318" @default.
• W2806081567 hasPublicationYear "2018" @default.
• W2806081567 type Work @default.
• W2806081567 sameAs 2806081567 @default.
• W2806081567 citedByCount "7" @default.
• W2806081567 countsByYear W28060815672019 @default.
• W2806081567 countsByYear W28060815672021 @default.
• W2806081567 countsByYear W28060815672022 @default.
• W2806081567 countsByYear W28060815672023 @default.
• W2806081567 crossrefType "journal-article" @default.
• W2806081567 hasAuthorship W2806081567A5003165688 @default.
• W2806081567 hasAuthorship W2806081567A5090831722 @default.
• W2806081567 hasBestOaLocation W28060815671 @default.
• W2806081567 hasConcept C104317684 @default.
• W2806081567 hasConcept C105702510 @default.
• W2806081567 hasConcept C129536746 @default.
• W2806081567 hasConcept C145103041 @default.
• W2806081567 hasConcept C196843134 @default.
• W2806081567 hasConcept C205583638 @default.
• W2806081567 hasConcept C2776908312 @default.
• W2806081567 hasConcept C2777164004 @default.
• W2806081567 hasConcept C2778403493 @default.
• W2806081567 hasConcept C2779329299 @default.
• W2806081567 hasConcept C2780868196 @default.
• W2806081567 hasConcept C40692019 @default.
• W2806081567 hasConcept C54355233 @default.
• W2806081567 hasConcept C86803240 @default.
• W2806081567 hasConcept C87073359 @default.
• W2806081567 hasConcept C95444343 @default.
• W2806081567 hasConceptScore W2806081567C104317684 @default.
• W2806081567 hasConceptScore W2806081567C105702510 @default.
• W2806081567 hasConceptScore W2806081567C129536746 @default.
• W2806081567 hasConceptScore W2806081567C145103041 @default.
• W2806081567 hasConceptScore W2806081567C196843134 @default.
• W2806081567 hasConceptScore W2806081567C205583638 @default.
• W2806081567 hasConceptScore W2806081567C2776908312 @default.
• W2806081567 hasConceptScore W2806081567C2777164004 @default.
• W2806081567 hasConceptScore W2806081567C2778403493 @default.
• W2806081567 hasConceptScore W2806081567C2779329299 @default.
• W2806081567 hasConceptScore W2806081567C2780868196 @default.
• W2806081567 hasConceptScore W2806081567C40692019 @default.
• W2806081567 hasConceptScore W2806081567C54355233 @default.
• W2806081567 hasConceptScore W2806081567C86803240 @default.
• W2806081567 hasConceptScore W2806081567C87073359 @default.
• W2806081567 hasConceptScore W2806081567C95444343 @default.
• W2806081567 hasFunder F4320309807 @default.
• W2806081567 hasFunder F4320325387 @default.
• W2806081567 hasIssue "4" @default.
• W2806081567 hasLocation W28060815671 @default.
• W2806081567 hasLocation W28060815672 @default.
• W2806081567 hasLocation W28060815673 @default.
• W2806081567 hasOpenAccess W2806081567 @default.
• W2806081567 hasPrimaryLocation W28060815671 @default.
• W2806081567 hasRelatedWork W1964266829 @default.
• W2806081567 hasRelatedWork W2021239367 @default.
• W2806081567 hasRelatedWork W2026298450 @default.
• W2806081567 hasRelatedWork W2044160104 @default.
• W2806081567 hasRelatedWork W2059600861 @default.
• W2806081567 hasRelatedWork W2126242656 @default.
• W2806081567 hasRelatedWork W2144831379 @default.
• W2806081567 hasRelatedWork W2254825490 @default.
• W2806081567 hasRelatedWork W2806081567 @default.
• W2806081567 hasRelatedWork W3198456384 @default.
• W2806081567 hasVolume "60" @default.

• next