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- W2806087678 abstract "The bacterial cell wall is a complex polymeric structure with essential roles in defence, survival and pathogenesis. Common to both Gram-positive and Gram-negative bacteria is the mesh-like peptidoglycan sacculus that surrounds the outer leaflet of the cytoplasmic membrane. Recent crystallographic studies of enzymes that comprise the peptidoglycan biosynthetic pathway have led to significant new understanding of all stages. These include initial multi-step cytosolic formation of sugar-pentapeptide precursors, transfer of the precursors to activated polyprenyl lipids at the membrane inner leaflet and flippase mediated relocalization of the resulting lipid II precursors to the outer leaflet where glycopolymerization and subsequent peptide crosslinking are finalized. Additional, species-specific enzymes allow customized peptidoglycan modifications and biosynthetic regulation that are important to bacterial virulence and survival. These studies have reinforced the unique and specific catalytic mechanisms at play in cell wall biogenesis and expanded the atomic foundation to develop novel, structure guided, antibacterial agents." @default.
- W2806087678 created "2018-06-13" @default.
- W2806087678 creator A5022292484 @default.
- W2806087678 creator A5024546227 @default.
- W2806087678 creator A5029957220 @default.
- W2806087678 date "2018-12-01" @default.
- W2806087678 modified "2023-10-07" @default.
- W2806087678 title "Enzyme structures of the bacterial peptidoglycan and wall teichoic acid biogenesis pathways" @default.
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- W2806087678 doi "https://doi.org/10.1016/j.sbi.2018.05.002" @default.
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