Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806115346> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2806115346 endingPage "506" @default.
- W2806115346 startingPage "506" @default.
- W2806115346 abstract "The oxygen partial pressure in the interstitial space (PO2is) drives O2 diffusion into the myocyte thus supporting oxidative phosphorylation. Although crucial for metabolic recovery and the capacity to perform repetitive tasks, the time course of skeletal muscle PO2is during recovery from contractions remains unknown. PURPOSE: To resolve the temporal profile and determine model parameters of PO2is off-kinetics after cessation of contractions in healthy skeletal muscle. We tested the hypothesis that PO2is would recover to resting values and display considerable on-off asymmetry (fast on- and slow off-kinetics) reflective of slower microcirculatory O2 delivery relative to muscle O2 utilization dynamics in recovery. Microvascular PO2 (PO2mv) was also evaluated to test the hypothesis that a significant transmural gradient (ΔPO2=PO2mv-PO2is) would be sustained during recovery. METHODS: PO2mv and PO2is were determined via phosphorescence quenching (Oxyphor probes G2 and G4, respectively) in the exposed rat spinotrapezius muscle during and after contractions (1 Hz, 6 V, 3 min per transition; n=12). RESULTS: Muscle PO2is rose progressively (p<0.05) from an end-contraction value of 11.2±1.5 to 17.6±2.2 mmHg at the end of the recovery period, which was not different from resting PO2is (17.8±1.9 mmHg; p>0.05). PO2is off-kinetics were slower than on-kinetics (mean response time: 49.3±12.4 vs. 19.2±2.5 s, respectively; p<0.05). A significant transmural ΔPO2 observed at the end of contractions (17.7±2.7 mmHg) was maintained throughout the recovery period (end-recovery: 19.3±4.5 mmHg; p>0.05). DISCUSSION: Consistent with our hypotheses, skeletal muscle PO2is recovered back to resting values with slower off-kinetics compared to the on-transient in line with the on-off asymmetry for capillary hemodynamics. Maintenance of a substantial transmural ΔPO2 during recovery supports that the microvascular-interstitium interface provides considerable resistance to O2 transport. As dictated by Fick’s law (V˙O2=DO2*ΔPO2), modulation of O2 flux during and following contractions (V˙O2) must be achieved via corresponding changes in effective diffusing capacity (DO2; mainly capillary red blood cell hemodynamics and distribution) in the face of unaltered ΔPO2. Funding: NIH HL-2-108328" @default.
- W2806115346 created "2018-06-13" @default.
- W2806115346 creator A5002404195 @default.
- W2806115346 creator A5029917042 @default.
- W2806115346 creator A5057426982 @default.
- W2806115346 creator A5066599322 @default.
- W2806115346 creator A5071657250 @default.
- W2806115346 creator A5084534681 @default.
- W2806115346 date "2018-05-01" @default.
- W2806115346 modified "2023-09-26" @default.
- W2806115346 title "Dynamics of Skeletal Muscle Interstitial PO2 During Recovery from Contractions" @default.
- W2806115346 doi "https://doi.org/10.1249/01.mss.0000536748.66222.2d" @default.
- W2806115346 hasPublicationYear "2018" @default.
- W2806115346 type Work @default.
- W2806115346 sameAs 2806115346 @default.
- W2806115346 citedByCount "0" @default.
- W2806115346 crossrefType "journal-article" @default.
- W2806115346 hasAuthorship W2806115346A5002404195 @default.
- W2806115346 hasAuthorship W2806115346A5029917042 @default.
- W2806115346 hasAuthorship W2806115346A5057426982 @default.
- W2806115346 hasAuthorship W2806115346A5066599322 @default.
- W2806115346 hasAuthorship W2806115346A5071657250 @default.
- W2806115346 hasAuthorship W2806115346A5084534681 @default.
- W2806115346 hasConcept C105702510 @default.
- W2806115346 hasConcept C121332964 @default.
- W2806115346 hasConcept C12554922 @default.
- W2806115346 hasConcept C126322002 @default.
- W2806115346 hasConcept C148898269 @default.
- W2806115346 hasConcept C150489694 @default.
- W2806115346 hasConcept C163415756 @default.
- W2806115346 hasConcept C178790620 @default.
- W2806115346 hasConcept C185592680 @default.
- W2806115346 hasConcept C2776050358 @default.
- W2806115346 hasConcept C2779959927 @default.
- W2806115346 hasConcept C540031477 @default.
- W2806115346 hasConcept C62520636 @default.
- W2806115346 hasConcept C71924100 @default.
- W2806115346 hasConcept C86803240 @default.
- W2806115346 hasConceptScore W2806115346C105702510 @default.
- W2806115346 hasConceptScore W2806115346C121332964 @default.
- W2806115346 hasConceptScore W2806115346C12554922 @default.
- W2806115346 hasConceptScore W2806115346C126322002 @default.
- W2806115346 hasConceptScore W2806115346C148898269 @default.
- W2806115346 hasConceptScore W2806115346C150489694 @default.
- W2806115346 hasConceptScore W2806115346C163415756 @default.
- W2806115346 hasConceptScore W2806115346C178790620 @default.
- W2806115346 hasConceptScore W2806115346C185592680 @default.
- W2806115346 hasConceptScore W2806115346C2776050358 @default.
- W2806115346 hasConceptScore W2806115346C2779959927 @default.
- W2806115346 hasConceptScore W2806115346C540031477 @default.
- W2806115346 hasConceptScore W2806115346C62520636 @default.
- W2806115346 hasConceptScore W2806115346C71924100 @default.
- W2806115346 hasConceptScore W2806115346C86803240 @default.
- W2806115346 hasIssue "5S" @default.
- W2806115346 hasLocation W28061153461 @default.
- W2806115346 hasOpenAccess W2806115346 @default.
- W2806115346 hasPrimaryLocation W28061153461 @default.
- W2806115346 hasRelatedWork W1809457125 @default.
- W2806115346 hasRelatedWork W2005279346 @default.
- W2806115346 hasRelatedWork W2015731959 @default.
- W2806115346 hasRelatedWork W2038997383 @default.
- W2806115346 hasRelatedWork W2076541326 @default.
- W2806115346 hasRelatedWork W2085469488 @default.
- W2806115346 hasRelatedWork W2411124164 @default.
- W2806115346 hasRelatedWork W2469324603 @default.
- W2806115346 hasRelatedWork W2900896225 @default.
- W2806115346 hasRelatedWork W3155717306 @default.
- W2806115346 hasVolume "50" @default.
- W2806115346 isParatext "false" @default.
- W2806115346 isRetracted "false" @default.
- W2806115346 magId "2806115346" @default.
- W2806115346 workType "article" @default.