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• W2806143103 abstract "Metabolic uncoupling has been well-characterized during the first minutes-to-days after a traumatic brain injury (TBI), yet mitochondrial bioenergetics during the weeks-to-months after a brain injury is poorly defined, particularly after a mild TBI. We hypothesized that a closed head injury (CHI) would be associated with deficits in mitochondrial bioenergetics at one month after the injury. A significant decrease in state-III (adenosine triphosphate production) and state-V (complex-I) driven mitochondrial respiration was found at one month post-injury in adult C57Bl/6J mice. Isolation of synaptic mitochondria demonstrated that the deficit in state-III and state-V was primarily neuronal. Injured mice had a temporally consistent deficit in memory recall at one month post-injury. Using proton magnetic resonance spectroscopy (1H MRS) at 7-Tesla, we found significant decreases in phosphocreatine, N-Acetylaspartic acid, and total choline. We also found regional variations in cerebral blood flow, including both hypo- and hyperperfusion, as measured by a pseudocontinuous arterial spin labeling MR sequence. Our results highlight a chronic deficit in mitochondrial bioenergetics associated with a CHI that may lead toward a novel approach for neurorestoration after a mild TBI. MRS provides a potential biomarker for assessing the efficacy of candidate treatments targeted at improving mitochondrial bioenergetics." @default.
• W2806143103 created "2018-06-13" @default.
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• W2806143103 date "2018-10-15" @default.
• W2806143103 modified "2023-10-11" @default.
• W2806143103 title "A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism" @default.
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• W2806143103 doi "https://doi.org/10.1089/neu.2018.5663" @default.
• W2806143103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6196750" @default.
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