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- W2806153048 abstract "Abstract Ring expansion provides a powerful way of introducing a heteroatom substituent into a carbocyclic framework. However, such reactions are often limited by the tendency of a given substrate to afford only one of the two rearrangement products or fail to achieve high selectivity at all. These limitations are particularly acute when seeking to carry out late-stage functionalization of natural products as starting points in drug discovery. In this work, we present a stereoelectronically controlled ring expansion sequence towards selective and flexible access to complementary ring systems derived from common steroidal substrates. Chemical diversification of the reaction intermediate affords over 100 isomerically pure analogs with spatial and functional diversity. This regiodivergent rearrangement, and the concept of using chiral reagents to affect regiocontrol in chiral natural products, should be broadly applicable to late-stage natural product diversification programs." @default.
- W2806153048 created "2018-06-13" @default.
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- W2806153048 date "2018-03-05" @default.
- W2806153048 modified "2023-09-27" @default.
- W2806153048 title "Reagent-controlled regiodivergent ring expansions of steroids" @default.
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- W2806153048 doi "https://doi.org/10.1038/s41467-018-03248-2" @default.
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