Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806187310> ?p ?o ?g. }
- W2806187310 abstract "MicroRNAs (miRNAs) play an important role in cancer biology. Neoadjuvant radiochemotherapy followed by surgery is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, a subset of patients do not respond. We evaluated whether miRNA profiles can predict resistance to radiochemotherapy. Formalin-fixed, paraffin-embedded pretherapeutic biopsies of patients treated by radiochemotherapy followed by esophagectomy were analyzed. The response was determined by histopathological tumor regression grading. miRNA profiling was performed by microarray analysis (Agilent platform) in 16 non-responders and 15 responders. Differentially expressed miRNAs were confirmed by real-time quantitative PCR (qRT-PCR) in an expanded cohort of 53 cases. The miRNA profiles within and between non-responders and responders were highly similar (r = 0.96, 0.94 and 0.95). However, 12 miRNAs were differentially expressed (> twofold; p ≤ 0.025): non-responders showed upregulation of hsa-miR-1323, hsa-miR-3678-3p, hsv2-miR-H7-3p, hsa-miR-194*, hsa-miR-3152, kshv-miR-K12-4-3p, hsa-miR-665 and hsa-miR-3659 and downregulation of hsa-miR-126*, hsa-miR-484, hsa-miR-330-3p and hsa-miR-3653. qRT-PCR analysis confirmed the microarray findings for hsa-miR-194* and hsa-miR-665 (p < 0.001 each) with AUC values of 0.811 (95% CI 0.694–0.927) and 0.817 (95% CI 0.704–0.930), respectively, in ROC analysis. Our results indicate that miRNAs are involved in the therapeutic response in ESCC and suggest that miRNA profiles could facilitate pretherapeutic patient selection." @default.
- W2806187310 created "2018-06-13" @default.
- W2806187310 creator A5016089837 @default.
- W2806187310 creator A5018744564 @default.
- W2806187310 creator A5022748731 @default.
- W2806187310 creator A5048250044 @default.
- W2806187310 creator A5061037633 @default.
- W2806187310 creator A5073982890 @default.
- W2806187310 creator A5076736029 @default.
- W2806187310 creator A5077799171 @default.
- W2806187310 creator A5091797746 @default.
- W2806187310 date "2018-04-25" @default.
- W2806187310 modified "2023-10-14" @default.
- W2806187310 title "MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus" @default.
- W2806187310 cites W144423133 @default.
- W2806187310 cites W1548923469 @default.
- W2806187310 cites W1903336194 @default.
- W2806187310 cites W1922694287 @default.
- W2806187310 cites W1970121668 @default.
- W2806187310 cites W1976830577 @default.
- W2806187310 cites W1996108510 @default.
- W2806187310 cites W2001879187 @default.
- W2806187310 cites W2015507847 @default.
- W2806187310 cites W2015858554 @default.
- W2806187310 cites W2026613554 @default.
- W2806187310 cites W2027618358 @default.
- W2806187310 cites W2030931565 @default.
- W2806187310 cites W2040350626 @default.
- W2806187310 cites W2054305985 @default.
- W2806187310 cites W2070555748 @default.
- W2806187310 cites W2076446307 @default.
- W2806187310 cites W2082344079 @default.
- W2806187310 cites W2087897888 @default.
- W2806187310 cites W2092444220 @default.
- W2806187310 cites W2098150408 @default.
- W2806187310 cites W2099918668 @default.
- W2806187310 cites W2113814947 @default.
- W2806187310 cites W2117821652 @default.
- W2806187310 cites W2123383301 @default.
- W2806187310 cites W2131237486 @default.
- W2806187310 cites W2140625837 @default.
- W2806187310 cites W2145702684 @default.
- W2806187310 cites W2146519879 @default.
- W2806187310 cites W2148815396 @default.
- W2806187310 cites W2154444715 @default.
- W2806187310 cites W2162587222 @default.
- W2806187310 cites W2164194749 @default.
- W2806187310 cites W2216643139 @default.
- W2806187310 cites W2292589236 @default.
- W2806187310 cites W2324476590 @default.
- W2806187310 cites W2468994417 @default.
- W2806187310 cites W2473776365 @default.
- W2806187310 cites W2510865815 @default.
- W2806187310 cites W2517570416 @default.
- W2806187310 cites W2522309607 @default.
- W2806187310 cites W2560820634 @default.
- W2806187310 cites W2588361821 @default.
- W2806187310 cites W2986750641 @default.
- W2806187310 cites W3023299375 @default.
- W2806187310 cites W4230938913 @default.
- W2806187310 doi "https://doi.org/10.1186/s12967-018-1492-9" @default.
- W2806187310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5954453" @default.
- W2806187310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29769068" @default.
- W2806187310 hasPublicationYear "2018" @default.
- W2806187310 type Work @default.
- W2806187310 sameAs 2806187310 @default.
- W2806187310 citedByCount "31" @default.
- W2806187310 countsByYear W28061873102018 @default.
- W2806187310 countsByYear W28061873102019 @default.
- W2806187310 countsByYear W28061873102020 @default.
- W2806187310 countsByYear W28061873102021 @default.
- W2806187310 countsByYear W28061873102022 @default.
- W2806187310 countsByYear W28061873102023 @default.
- W2806187310 crossrefType "journal-article" @default.
- W2806187310 hasAuthorship W2806187310A5016089837 @default.
- W2806187310 hasAuthorship W2806187310A5018744564 @default.
- W2806187310 hasAuthorship W2806187310A5022748731 @default.
- W2806187310 hasAuthorship W2806187310A5048250044 @default.
- W2806187310 hasAuthorship W2806187310A5061037633 @default.
- W2806187310 hasAuthorship W2806187310A5073982890 @default.
- W2806187310 hasAuthorship W2806187310A5076736029 @default.
- W2806187310 hasAuthorship W2806187310A5077799171 @default.
- W2806187310 hasAuthorship W2806187310A5091797746 @default.
- W2806187310 hasBestOaLocation W28061873101 @default.
- W2806187310 hasConcept C104317684 @default.
- W2806187310 hasConcept C121608353 @default.
- W2806187310 hasConcept C126322002 @default.
- W2806187310 hasConcept C127561419 @default.
- W2806187310 hasConcept C142724271 @default.
- W2806187310 hasConcept C143998085 @default.
- W2806187310 hasConcept C145059251 @default.
- W2806187310 hasConcept C150194340 @default.
- W2806187310 hasConcept C18431079 @default.
- W2806187310 hasConcept C186836561 @default.
- W2806187310 hasConcept C2777546739 @default.
- W2806187310 hasConcept C2777819096 @default.
- W2806187310 hasConcept C2778292576 @default.
- W2806187310 hasConcept C502942594 @default.
- W2806187310 hasConcept C530470458 @default.
- W2806187310 hasConcept C55493867 @default.