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• W2806187894 abstract "Abstract Public concerns over the use of synthetic pesticides are growing since many studies have shown their impact on human health. A new environmental movement in occidental countries promoting an organic agriculture favours the rebirth of botanical pesticides. These products confer an effective alternative to chemical pesticides such as glyphosate. Among the biopesticides, the α-terthienyls found in the roots of Tagetes species, are powerful broad-spectrum pesticides. We found that an α-terthienyl analogue with herbicidal properties, called A6, triggers resistant SDS oligomers of the pathogenic prion protein PrP Sc (rSDS-PrP Sc ) in cells. Our main question is to determine if we can induce those rSDS-PrP Sc oligomers in vitro and in vivo , and their impact on prion aggregation and propagation. Using wild-type mice challenged with prions, we showed that A6 accelerates or slows down prion disease depending on the concentration used. At 5 mg/kg, A6 is worsening the pathology with a faster accumulation of PrP Sc , reminiscent to soluble toxic rSDS-PrP Sc oligomers. In contrast, at 10 and 20 mg/kg of A6, prion disease occurred later, with less PrP Sc deposits and with rSDS-PrP Sc oligomers in the brain reminiscent to non-toxic aggregates. Our results are bringing new openings regarding the impact of biopesticides in prion and prion-like diseases." @default.
• W2806187894 created "2018-06-13" @default.
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• W2806187894 date "2018-05-23" @default.
• W2806187894 modified "2023-10-18" @default.
• W2806187894 title "Low doses of bioherbicide favour prion aggregation and propagation in vivo" @default.
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• W2806187894 doi "https://doi.org/10.1038/s41598-018-25966-9" @default.
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