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- W2806192300 abstract "Abstract Infective endocarditis (IE) is associated with high morbidity and mortality rates. The predominant bacteria causing IE is Staphylococcus aureus ( S. aureus ), which can bind to existing thrombi on heart valves and generate vegetations (biofilms). In this in vitro flow study, we evaluated sonobactericide as a novel strategy to treat IE, using ultrasound and an ultrasound contrast agent with or without other therapeutics. We developed a model of IE biofilm using human whole-blood clots infected with patient-derived S. aureus (infected clots). Histology and live-cell imaging revealed a biofilm layer of fibrin-embedded living Staphylococci around a dense erythrocyte core. Infected clots were treated under flow for 30 minutes and degradation was assessed by time-lapse microscopy imaging. Treatments consisted of either continuous plasma flow alone or with different combinations of therapeutics: oxacillin (antibiotic), recombinant tissue plasminogen activator (rt-PA; thrombolytic), intermittent continuous-wave low-frequency ultrasound (120-kHz, 0.44 MPa peak-to-peak pressure), and an ultrasound contrast agent (Definity). Infected clots exposed to the combination of oxacillin, rt-PA, ultrasound, and Definity achieved 99.3 ± 1.7% loss, which was greater than the other treatment arms. Effluent size measurements suggested low likelihood of emboli formation. These results support the continued investigation of sonobactericide as a therapeutic strategy for IE." @default.
- W2806192300 created "2018-06-13" @default.
- W2806192300 creator A5006596748 @default.
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- W2806192300 date "2018-02-21" @default.
- W2806192300 modified "2023-09-25" @default.
- W2806192300 title "An in vitro proof-of-principle study of sonobactericide" @default.
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- W2806192300 doi "https://doi.org/10.1038/s41598-018-21648-8" @default.
- W2806192300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5821825" @default.
- W2806192300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29467474" @default.
- W2806192300 hasPublicationYear "2018" @default.
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