Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806244807> ?p ?o ?g. }
- W2806244807 endingPage "334" @default.
- W2806244807 startingPage "327" @default.
- W2806244807 abstract "Antidepressants are the most commonly prescribed drugs for psychiatric treatment, and venlafaxine (VEN) is one of the most popular options. Venlafaxine is a nontricyclic dual-acting serotonin-norepinephrine reuptake inhibitor. Although an increased incidence of acute toxicity and addiction has been reported, controlled studies examining its toxic effects on different organs are still lacking. This study investigated the possible toxic effects of VEN on the liver, kidney, and gastric tissues. Three groups of rats were administered saline, a single LD50 dose (350 mg/kg), or 100 mg/kg VEN daily, followed by increases in the dose of 50 mg/kg every 10 days for 30 days (about 10 times the therapeutic doses). The following parameters of liver and kidney injury were then assayed: alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, prothrombin time, partial thromboplastin time, blood urea nitrogen, and serum creatinine. A histopathological examination was then conducted. Both acute and subchronic administration of VEN produced multiple clinical manifestations in the experimental animals, including seizures, coma, and even death. Moreover, the liver and renal function tests indicated injury in these tissues. Furthermore, the histopathological examination showed signs of organ toxicity after both acute and chronic VEN exposure. This study has shown that VEN has harmful effects on the liver, kidney, and stomach in either a single high dose (LD50) or repeated exposure to 10 times the therapeutic doses. As a result, strategies to increase awareness of these effects among physicians and the public are needed because this drug may be addictive." @default.
- W2806244807 created "2018-06-13" @default.
- W2806244807 creator A5009509569 @default.
- W2806244807 creator A5026587615 @default.
- W2806244807 creator A5048302974 @default.
- W2806244807 creator A5079399719 @default.
- W2806244807 date "2018-06-03" @default.
- W2806244807 modified "2023-10-16" @default.
- W2806244807 title "Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats" @default.
- W2806244807 cites W1430921768 @default.
- W2806244807 cites W1563157005 @default.
- W2806244807 cites W180162702 @default.
- W2806244807 cites W1814008725 @default.
- W2806244807 cites W1838817569 @default.
- W2806244807 cites W1865884133 @default.
- W2806244807 cites W1964563171 @default.
- W2806244807 cites W1970727094 @default.
- W2806244807 cites W1971166360 @default.
- W2806244807 cites W1975041505 @default.
- W2806244807 cites W1980168340 @default.
- W2806244807 cites W1986313670 @default.
- W2806244807 cites W2002470967 @default.
- W2806244807 cites W2003333386 @default.
- W2806244807 cites W2004502741 @default.
- W2806244807 cites W2015741566 @default.
- W2806244807 cites W2033580693 @default.
- W2806244807 cites W2033887363 @default.
- W2806244807 cites W2045980664 @default.
- W2806244807 cites W2068083208 @default.
- W2806244807 cites W2075103004 @default.
- W2806244807 cites W2076781001 @default.
- W2806244807 cites W2078585945 @default.
- W2806244807 cites W2081508080 @default.
- W2806244807 cites W2088495361 @default.
- W2806244807 cites W2097680301 @default.
- W2806244807 cites W2113278271 @default.
- W2806244807 cites W2121836743 @default.
- W2806244807 cites W2122307046 @default.
- W2806244807 cites W2142158961 @default.
- W2806244807 cites W2148069408 @default.
- W2806244807 cites W2151323454 @default.
- W2806244807 cites W2156641852 @default.
- W2806244807 cites W2157621441 @default.
- W2806244807 cites W2159325340 @default.
- W2806244807 cites W2159785685 @default.
- W2806244807 cites W2286137651 @default.
- W2806244807 cites W2290466312 @default.
- W2806244807 cites W2340520094 @default.
- W2806244807 cites W2414615919 @default.
- W2806244807 cites W2422059835 @default.
- W2806244807 cites W2424353249 @default.
- W2806244807 cites W2519461624 @default.
- W2806244807 cites W2579969776 @default.
- W2806244807 cites W2606723376 @default.
- W2806244807 cites W2770175517 @default.
- W2806244807 cites W4229594069 @default.
- W2806244807 doi "https://doi.org/10.1177/1091581818777470" @default.
- W2806244807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29862856" @default.
- W2806244807 hasPublicationYear "2018" @default.
- W2806244807 type Work @default.
- W2806244807 sameAs 2806244807 @default.
- W2806244807 citedByCount "5" @default.
- W2806244807 countsByYear W28062448072021 @default.
- W2806244807 countsByYear W28062448072022 @default.
- W2806244807 crossrefType "journal-article" @default.
- W2806244807 hasAuthorship W2806244807A5009509569 @default.
- W2806244807 hasAuthorship W2806244807A5026587615 @default.
- W2806244807 hasAuthorship W2806244807A5048302974 @default.
- W2806244807 hasAuthorship W2806244807A5079399719 @default.
- W2806244807 hasBestOaLocation W28062448071 @default.
- W2806244807 hasConcept C126322002 @default.
- W2806244807 hasConcept C2776466888 @default.
- W2806244807 hasConcept C2778176769 @default.
- W2806244807 hasConcept C2779177272 @default.
- W2806244807 hasConcept C2780091579 @default.
- W2806244807 hasConcept C2780306776 @default.
- W2806244807 hasConcept C2781161787 @default.
- W2806244807 hasConcept C29730261 @default.
- W2806244807 hasConcept C71924100 @default.
- W2806244807 hasConcept C98274493 @default.
- W2806244807 hasConceptScore W2806244807C126322002 @default.
- W2806244807 hasConceptScore W2806244807C2776466888 @default.
- W2806244807 hasConceptScore W2806244807C2778176769 @default.
- W2806244807 hasConceptScore W2806244807C2779177272 @default.
- W2806244807 hasConceptScore W2806244807C2780091579 @default.
- W2806244807 hasConceptScore W2806244807C2780306776 @default.
- W2806244807 hasConceptScore W2806244807C2781161787 @default.
- W2806244807 hasConceptScore W2806244807C29730261 @default.
- W2806244807 hasConceptScore W2806244807C71924100 @default.
- W2806244807 hasConceptScore W2806244807C98274493 @default.
- W2806244807 hasIssue "4" @default.
- W2806244807 hasLocation W28062448071 @default.
- W2806244807 hasLocation W28062448072 @default.
- W2806244807 hasOpenAccess W2806244807 @default.
- W2806244807 hasPrimaryLocation W28062448071 @default.
- W2806244807 hasRelatedWork W1999941077 @default.
- W2806244807 hasRelatedWork W2039328388 @default.
- W2806244807 hasRelatedWork W2087067429 @default.