FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2806309092> ?p ?o ?g. }

• W2806309092 endingPage "172" @default.
• W2806309092 startingPage "165" @default.
• W2806309092 abstract "Gallstone disease (GD) is highly correlated with metabolic syndrome and its related illnesses including type II diabetes (DMII) and polycystic ovary syndrome (PCOS). While previous studies claimed that metformin decreases the chance of developing GD in PCOS patients, this phenomenon has not been investigated in animal models to date. Here we fed a high fat diet (HFD) containing 2% of cholesterol and 1% of cholic acid to ten-week-old male C57Bl/6 mice for 105 days. The groups were as follows: Low fat diet; HFD; HFD + Ursodeoxycholic acid (UDCA) (day 1–105); HFD + Metformin (day 1–105); HFD + Metformin (Met) (day 64–105). All drugs were administered by oral gavage (Met = 300 mg/kg & UDCA = 750 mg/kg). Serum lipid profile and gross organ examination were performed after euthanasia. A microscopic evaluation of the paraffin-embedded gallbladders was done after hematoxylin & eosin and Von Kossa staining. HFD successfully induces gallstone (4 out of 4 of the HFD members). While both UDCA and metformin (d 1–105) prevented gallstone formation and cholecystitis, Metformin (d 64–105) group had a few small stones. Additionally, metformin induces mucosal calcification in gallbladder (porcelain GB) of more than 80% of the HFD + Met (day 1–105) and HFD + Met (day 64–105) groups, collectively, which can be a potential problem by itself. While metformin shows a noticeable benefit towards GB health by reducing the chance for gallstone formation, if it induces porcelain gallbladder in humans as well, it might inflict patients with preventable medical charges." @default.
• W2806309092 created "2018-06-13" @default.
• W2806309092 creator A5041070153 @default.
• W2806309092 creator A5063942399 @default.
• W2806309092 creator A5072815656 @default.
• W2806309092 creator A5078307612 @default.
• W2806309092 creator A5083925346 @default.
• W2806309092 creator A5091259859 @default.
• W2806309092 date "2018-08-01" @default.
• W2806309092 modified "2023-09-25" @default.
• W2806309092 title "Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice" @default.
• W2806309092 cites W1511210758 @default.
• W2806309092 cites W1530129189 @default.
• W2806309092 cites W1833437097 @default.
• W2806309092 cites W1872573833 @default.
• W2806309092 cites W1879942467 @default.
• W2806309092 cites W1965891356 @default.
• W2806309092 cites W1979699925 @default.
• W2806309092 cites W1989023250 @default.
• W2806309092 cites W1997477483 @default.
• W2806309092 cites W2001599368 @default.
• W2806309092 cites W2003283044 @default.
• W2806309092 cites W2005306945 @default.
• W2806309092 cites W2012192962 @default.
• W2806309092 cites W2015311622 @default.
• W2806309092 cites W2039851346 @default.
• W2806309092 cites W2062347968 @default.
• W2806309092 cites W2066579275 @default.
• W2806309092 cites W2069828527 @default.
• W2806309092 cites W2085331940 @default.
• W2806309092 cites W2088040369 @default.
• W2806309092 cites W2107479916 @default.
• W2806309092 cites W2110828138 @default.
• W2806309092 cites W2124316292 @default.
• W2806309092 cites W2133520841 @default.
• W2806309092 cites W2144528369 @default.
• W2806309092 cites W2148755064 @default.
• W2806309092 cites W2151405349 @default.
• W2806309092 cites W2158339221 @default.
• W2806309092 cites W2162365554 @default.
• W2806309092 cites W2164361361 @default.
• W2806309092 cites W2169738431 @default.
• W2806309092 cites W2473725818 @default.
• W2806309092 cites W2598445433 @default.
• W2806309092 doi "https://doi.org/10.1016/j.ejphar.2018.06.002" @default.
• W2806309092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29883669" @default.
• W2806309092 hasPublicationYear "2018" @default.
• W2806309092 type Work @default.
• W2806309092 sameAs 2806309092 @default.
• W2806309092 citedByCount "12" @default.
• W2806309092 countsByYear W28063090922019 @default.
• W2806309092 countsByYear W28063090922021 @default.
• W2806309092 countsByYear W28063090922022 @default.
• W2806309092 countsByYear W28063090922023 @default.
• W2806309092 crossrefType "journal-article" @default.
• W2806309092 hasAuthorship W2806309092A5041070153 @default.
• W2806309092 hasAuthorship W2806309092A5063942399 @default.
• W2806309092 hasAuthorship W2806309092A5072815656 @default.
• W2806309092 hasAuthorship W2806309092A5078307612 @default.
• W2806309092 hasAuthorship W2806309092A5083925346 @default.
• W2806309092 hasAuthorship W2806309092A5091259859 @default.
• W2806309092 hasConcept C125473707 @default.
• W2806309092 hasConcept C126322002 @default.
• W2806309092 hasConcept C134018914 @default.
• W2806309092 hasConcept C204232928 @default.
• W2806309092 hasConcept C2775900799 @default.
• W2806309092 hasConcept C2777148285 @default.
• W2806309092 hasConcept C2777391703 @default.
• W2806309092 hasConcept C2779388726 @default.
• W2806309092 hasConcept C2779399885 @default.
• W2806309092 hasConcept C2780323712 @default.
• W2806309092 hasConcept C2780354107 @default.
• W2806309092 hasConcept C2780965833 @default.
• W2806309092 hasConcept C2910747057 @default.
• W2806309092 hasConcept C3018442814 @default.
• W2806309092 hasConcept C555293320 @default.
• W2806309092 hasConcept C71924100 @default.
• W2806309092 hasConcept C90924648 @default.
• W2806309092 hasConceptScore W2806309092C125473707 @default.
• W2806309092 hasConceptScore W2806309092C126322002 @default.
• W2806309092 hasConceptScore W2806309092C134018914 @default.
• W2806309092 hasConceptScore W2806309092C204232928 @default.
• W2806309092 hasConceptScore W2806309092C2775900799 @default.
• W2806309092 hasConceptScore W2806309092C2777148285 @default.
• W2806309092 hasConceptScore W2806309092C2777391703 @default.
• W2806309092 hasConceptScore W2806309092C2779388726 @default.
• W2806309092 hasConceptScore W2806309092C2779399885 @default.
• W2806309092 hasConceptScore W2806309092C2780323712 @default.
• W2806309092 hasConceptScore W2806309092C2780354107 @default.
• W2806309092 hasConceptScore W2806309092C2780965833 @default.
• W2806309092 hasConceptScore W2806309092C2910747057 @default.
• W2806309092 hasConceptScore W2806309092C3018442814 @default.
• W2806309092 hasConceptScore W2806309092C555293320 @default.
• W2806309092 hasConceptScore W2806309092C71924100 @default.
• W2806309092 hasConceptScore W2806309092C90924648 @default.
• W2806309092 hasFunder F4320322545 @default.
• W2806309092 hasLocation W28063090921 @default.
• W2806309092 hasLocation W28063090922 @default.

• next